Current Bioinformatics,
Journal Year:
2024,
Volume and Issue:
20(2), P. 103 - 119
Published: Oct. 14, 2024
Peptidomics
is
the
study
of
total
peptides
that
describe
functions,
structures,
and
interactions
within
living
organisms.
It
comprises
bioactive
derived
naturally
or
synthetically
designed
exhibit
various
therapeutic
properties
against
microbial
infections,
cancer
progression,
inflammation,
etc.
With
current
state
art,
Bioinformatics
tools
techniques
help
analyse
large
peptidomics
data
predict
peptide
structure
functions.
also
aids
in
designing
with
enhanced
stability
efficacy.
studies
are
gaining
importance
therapeutics
as
they
offer
increased
target
specificity
least
side
effects.
The
molecular
size
flexibility
make
them
a
potential
drug
candidate
for
protein-protein
interaction
inhibitors.
These
features
their
potency
considerable
increase
number
drugs
available
market
health
commodities.
present
review
extensively
analyses
field,
focusing
on
different
therapeutics,
such
anticancer
drugs.
Further,
provides
comprehensive
information
silico
research.
personalised
medicines
disease
therapy
discussed
along
case
study.
major
limitations
strategies
to
overcome
those
reviewed.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(2), P. 990 - 1009
Published: Jan. 23, 2024
Skin
photoaging,
resulting
from
prolonged
exposure
to
ultraviolet
radiation,
is
a
form
of
exogenous
aging
that
not
only
impacts
the
aesthetic
aspect
skin
but
also
exhibits
strong
correlation
with
onset
cancer.
Nonetheless,
safety
profile
non-natural
anti-photoaging
medications
and
underlying
physiological
alterations
during
process
photoaging
remain
inadequately
elucidated.
Consequently,
there
exists
pressing
necessity
devise
more
secure
interventions
involving
drugs.
Multiple
studies
have
demonstrated
noteworthy
significance
marine
biomolecules
in
addressing
concerns
related
safeguarding
skin.
Notably,
bioactive
peptides
gained
considerable
attention
research
due
their
capacity
mitigate
associated
including
oxidative
stress;
inflammatory
response;
abnormal
expression
matrix
metalloproteinase,
hyaluronidase,
elastase;
excessive
melanin
synthesis.
This
review
provides
systematic
description
progress
on
protection
mechanism
peptides.
The
focus
utilization
as
agents,
aiming
offer
theoretical
references
for
development
novel
drugs
methodologies.
Additionally,
future
prospects
anti-aging
are
discussed,
providing
an
initial
reference
further
this
field.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(4), P. 159 - 159
Published: March 30, 2024
Aging
is
closely
associated
with
collagen
degradation,
impacting
the
structure
and
strength
of
muscles,
joints,
bones,
skin.
The
continuous
aging
skin
a
natural
process
that
influenced
by
extrinsic
factors
such
as
UV
exposure,
dietary
patterns,
smoking
habits,
cosmetic
supplements.
Supplements
contain
can
act
remedies
help
restore
vitality
youth
to
skin,
helping
combat
aging.
Notably,
supplements
enriched
essential
amino
acids
proline
glycine,
along
marine
fish
collagen,
have
become
popular
for
their
safety
effectiveness
in
mitigating
process.
To
compile
relevant
literature
on
anti-aging
applications
search
analysis
peer-reviewed
papers
was
conducted
using
PubMed,
Cochrane
Library,
Web
Science,
Embase,
covering
publications
from
1991
2024.
From
vitro
vivo
experiments,
reviewed
studies
elucidate
benefits
emphasizing
its
role
combating
minimizing
oxidative
stress,
photodamage,
appearance
wrinkles.
Various
bioactive
peptides
exhibit
diverse
properties,
including
free
radical
scavenging,
apoptosis
inhibition,
lifespan
extension
various
organisms,
protective
effects
humans.
Furthermore,
topical
application
hyaluronic
acid
discussed
mechanism
increase
production
moisture,
contributing
supplementation.
integration
bio-tissue
engineering
also
explored,
highlighting
proven
utility
healing
bone
regeneration
applications.
However,
limitations
scope
exist.
Thus,
delving
into
these
nuanced
considerations,
this
review
contributes
comprehensive
understanding
potential
challenges
realm
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(4), P. 151 - 151
Published: March 28, 2024
Metabolic
disorders
are
increasingly
prevalent
conditions
that
manifest
pathophysiologically
along
a
continuum.
Among
reported
metabolic
risk
factors,
elevated
fasting
serum
glucose
(FSG)
levels
have
shown
the
most
substantial
increase
in
exposure.
Ultimately
leading
to
insulin
resistance
(IR),
this
condition
is
associated
with
notable
deteriorations
prognostic
outlook
for
major
diseases,
including
neurodegenerative
cancer
risk,
and
mortality
related
cardiovascular
disease.
Tackling
dysfunction,
focus
on
prevention,
critically
important
aspect
human
health.
In
study,
an
investigation
into
potential
antidiabetic
properties
of
salmon
protein
hydrolysate
(SPH)
was
conducted,
focusing
its
dipeptidyl
peptidase-IV
(DPP-IV)
inhibition
direct
uptake
vitro.
Characterization
SPH
utilized
bioassay-guided
fractionation
approach
identify
potent
glucoregulatory
peptide
fractions.
Low-molecular-weight
(MW)
fractions
prepared
by
membrane
filtration
(MWCO
=
3
kDa)
showed
significant
DPP-IV
(IC50
1.01
±
0.12
mg/mL)
vitro
(p
≤
0.0001
at
1
mg/mL).
Further
lowest
MW
(<3
derived
from
permeate
resulted
three
subfractions.
The
subfraction
molecular
weight
demonstrated
activity
0.0001),
maintaining
potency
even
dilution
1:500
0.01).
iScience,
Journal Year:
2024,
Volume and Issue:
27(12), P. 111339 - 111339
Published: Nov. 7, 2024
As
the
global
population
continues
to
grow,
so
does
demand
for
longer,
healthier
lives
and
environmentally
responsible
choices.
Consumers
are
increasingly
drawn
naturally
sourced
products
with
proven
health
wellbeing
benefits.
The
marine
environment
presents
a
promising
yet
underexplored
resource
cosmetics
industry,
offering
bioactive
compounds
potential
safe
biocompatible
ingredients.
This
manuscript
provides
comprehensive
overview
of
organisms
production,
highlighting
marine-derived
their
applications
in
skin/hair/oral-care
products,
cosmeceuticals
more.
It
also
lays
down
critical
safety
considerations
addresses
methodologies
sourcing
compounds,
including
harvesting,
biorefinery
concept,
use
systems
biology
enhanced
product
development,
relevant
regulatory
landscape.
review
is
enriched
by
three
case
studies:
design
macroalgal
skincare
Iceland,
establishment
microalgal
spin-off
Italy,
utilization
proteins
cosmeceutical
applications.
Aging,
a
natural
process
occurring
in
both
normal
and
degenerative
conditions,
is
closely
associated
with
collagen
degradation,
impacting
various
bodily
systems
such
as
the
skin.
The
continuous
aging
of
skin,
influenced
by
intrinsic
extrinsic
factors,
underscores
importance
dermatological
cosmetic
contexts.
Notably,
supplements
enriched
essential
amino
acids
like
proline
glycine
along
marine
fish
have
become
popular
for
their
safety
effectiveness
mitigating
process.
To
compile
relevant
literature
on
anti-aging
applications
collagen,
systematic
search
analysis
peer-reviewed
papers
was
conducted
using
reputable
databases
including
PubMed,
Cochrane
Library,
Web
Science,
Embase,
covering
publications
from
1956
to
2023.
From
vitro
vivo
experiments,
reviewed
studies
elucidate
benefits
emphasizing
its
role
combating
skin
promoting
overall
health.
Many
bioactive
peptides
exhibit
diverse
properties,
free
radical
scavenging,
apoptosis
inhibition,
lifespan
extension
organisms,
protective
effects
humans.
Furthermore,
peptide
production
hyaluronic
acid
discussed
mechanism
fortify
enhance
moisture,
contributing
supplementation.
integration
bio-tissue
engineering
also
explored,
highlighting
proven
utility
addressing
bone
damage.
Insights
this
review
illuminate
biomedical
alongside
keystone
molecular
editing
tools
CRISPR,
positioning
it
versatile
resource
interventions.
However,
limitations
scope
application
exist.
Thus,
delving
into
these
nuanced
considerations,
contributes
comprehensive
understanding
potential
challenges
realm
applications.
