Intersecting Peptidomics and Bioactive Peptides in Drug Therapeutics DOI

Anagha Balakrishnan,

Saurav Kumar Mishra, Kanchan Sharma

et al.

Current Bioinformatics, Journal Year: 2024, Volume and Issue: 20(2), P. 103 - 119

Published: Oct. 14, 2024

Peptidomics is the study of total peptides that describe functions, structures, and interactions within living organisms. It comprises bioactive derived naturally or synthetically designed exhibit various therapeutic properties against microbial infections, cancer progression, inflammation, etc. With current state art, Bioinformatics tools techniques help analyse large peptidomics data predict peptide structure functions. also aids in designing with enhanced stability efficacy. studies are gaining importance therapeutics as they offer increased target specificity least side effects. The molecular size flexibility make them a potential drug candidate for protein-protein interaction inhibitors. These features their potency considerable increase number drugs available market health commodities. present review extensively analyses field, focusing on different therapeutics, such anticancer drugs. Further, provides comprehensive information silico research. personalised medicines disease therapy discussed along case study. major limitations strategies to overcome those reviewed.

Language: Английский

Bioactive peptides with antioxidant and ACE inhibitory properties in goat milk protein hydrolysates: Peptidomics and molecular docking study DOI
Wenhua Zhang,

Mohamed Aamer Abubaker,

Zekun Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140286 - 140286

Published: Jan. 23, 2025

Language: Английский

Citations

2

Collagen-derived peptides as prebiotics to improve gut health DOI

Baojing Ren,

Kaiyan Yue,

Yuhao Zhang

et al.

Current Opinion in Food Science, Journal Year: 2024, Volume and Issue: 55, P. 101123 - 101123

Published: Jan. 6, 2024

Language: Английский

Citations

11

Marine Bioactive Peptides: Anti-Photoaging Mechanisms and Potential Skin Protective Effects DOI Creative Commons
Xiaoliang Zhang, Hong Zhuang, Sijia Wu

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(2), P. 990 - 1009

Published: Jan. 23, 2024

Skin photoaging, resulting from prolonged exposure to ultraviolet radiation, is a form of exogenous aging that not only impacts the aesthetic aspect skin but also exhibits strong correlation with onset cancer. Nonetheless, safety profile non-natural anti-photoaging medications and underlying physiological alterations during process photoaging remain inadequately elucidated. Consequently, there exists pressing necessity devise more secure interventions involving drugs. Multiple studies have demonstrated noteworthy significance marine biomolecules in addressing concerns related safeguarding skin. Notably, bioactive peptides gained considerable attention research due their capacity mitigate associated including oxidative stress; inflammatory response; abnormal expression matrix metalloproteinase, hyaluronidase, elastase; excessive melanin synthesis. This review provides systematic description progress on protection mechanism peptides. The focus utilization as agents, aiming offer theoretical references for development novel drugs methodologies. Additionally, future prospects anti-aging are discussed, providing an initial reference further this field.

Language: Английский

Citations

9

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging DOI Creative Commons
M. Azizur Rahman, Rameesha Rehmani, Diana Gabby Pirvu

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 159 - 159

Published: March 30, 2024

Aging is closely associated with collagen degradation, impacting the structure and strength of muscles, joints, bones, skin. The continuous aging skin a natural process that influenced by extrinsic factors such as UV exposure, dietary patterns, smoking habits, cosmetic supplements. Supplements contain can act remedies help restore vitality youth to skin, helping combat aging. Notably, supplements enriched essential amino acids proline glycine, along marine fish collagen, have become popular for their safety effectiveness in mitigating process. To compile relevant literature on anti-aging applications search analysis peer-reviewed papers was conducted using PubMed, Cochrane Library, Web Science, Embase, covering publications from 1991 2024. From vitro vivo experiments, reviewed studies elucidate benefits emphasizing its role combating minimizing oxidative stress, photodamage, appearance wrinkles. Various bioactive peptides exhibit diverse properties, including free radical scavenging, apoptosis inhibition, lifespan extension various organisms, protective effects humans. Furthermore, topical application hyaluronic acid discussed mechanism increase production moisture, contributing supplementation. integration bio-tissue engineering also explored, highlighting proven utility healing bone regeneration applications. However, limitations scope exist. Thus, delving into these nuanced considerations, this review contributes comprehensive understanding potential challenges realm

Language: Английский

Citations

9

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro DOI Creative Commons

Christian Bjerknes,

Sileshi Gizachew Wubshet, Sissel Beate Rønning

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 151 - 151

Published: March 28, 2024

Metabolic disorders are increasingly prevalent conditions that manifest pathophysiologically along a continuum. Among reported metabolic risk factors, elevated fasting serum glucose (FSG) levels have shown the most substantial increase in exposure. Ultimately leading to insulin resistance (IR), this condition is associated with notable deteriorations prognostic outlook for major diseases, including neurodegenerative cancer risk, and mortality related cardiovascular disease. Tackling dysfunction, focus on prevention, critically important aspect human health. In study, an investigation into potential antidiabetic properties of salmon protein hydrolysate (SPH) was conducted, focusing its dipeptidyl peptidase-IV (DPP-IV) inhibition direct uptake vitro. Characterization SPH utilized bioassay-guided fractionation approach identify potent glucoregulatory peptide fractions. Low-molecular-weight (MW) fractions prepared by membrane filtration (MWCO = 3 kDa) showed significant DPP-IV (IC50 1.01 ± 0.12 mg/mL) vitro (p ≤ 0.0001 at 1 mg/mL). Further lowest MW (<3 derived from permeate resulted three subfractions. The subfraction molecular weight demonstrated activity 0.0001), maintaining potency even dilution 1:500 0.01).

Language: Английский

Citations

8

Marine peptides as potential anti-aging agents: Preparation, characterization, mechanisms of action, and future perspectives DOI
Wanzi Yao, Yifeng Zhang,

Gaiping Zhang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140413 - 140413

Published: July 14, 2024

Language: Английский

Citations

8

Marine cosmetics and the blue bioeconomy: from sourcing to success stories DOI Creative Commons
Ana Rotter,

Despoina Varamogianni-Mamatsi,

Alenka Zvonar Pobirk

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111339 - 111339

Published: Nov. 7, 2024

As the global population continues to grow, so does demand for longer, healthier lives and environmentally responsible choices. Consumers are increasingly drawn naturally sourced products with proven health wellbeing benefits. The marine environment presents a promising yet underexplored resource cosmetics industry, offering bioactive compounds potential safe biocompatible ingredients. This manuscript provides comprehensive overview of organisms production, highlighting marine-derived their applications in skin/hair/oral-care products, cosmeceuticals more. It also lays down critical safety considerations addresses methodologies sourcing compounds, including harvesting, biorefinery concept, use systems biology enhanced product development, relevant regulatory landscape. review is enriched by three case studies: design macroalgal skincare Iceland, establishment microalgal spin-off Italy, utilization proteins cosmeceutical applications.

Language: Английский

Citations

6

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Aging DOI Open Access
M. Azizur Rahman, Rameesha Rehmani, Diana Gabby Pirvu

et al.

Published: Jan. 25, 2024

Aging, a natural process occurring in both normal and degenerative conditions, is closely associated with collagen degradation, impacting various bodily systems such as the skin. The continuous aging of skin, influenced by intrinsic extrinsic factors, underscores importance dermatological cosmetic contexts. Notably, supplements enriched essential amino acids like proline glycine along marine fish have become popular for their safety effectiveness mitigating process. To compile relevant literature on anti-aging applications collagen, systematic search analysis peer-reviewed papers was conducted using reputable databases including PubMed, Cochrane Library, Web Science, Embase, covering publications from 1956 to 2023. From vitro vivo experiments, reviewed studies elucidate benefits emphasizing its role combating skin promoting overall health. Many bioactive peptides exhibit diverse properties, free radical scavenging, apoptosis inhibition, lifespan extension organisms, protective effects humans. Furthermore, peptide production hyaluronic acid discussed mechanism fortify enhance moisture, contributing supplementation. integration bio-tissue engineering also explored, highlighting proven utility addressing bone damage. Insights this review illuminate biomedical alongside keystone molecular editing tools CRISPR, positioning it versatile resource interventions. However, limitations scope application exist. Thus, delving into these nuanced considerations, contributes comprehensive understanding potential challenges realm applications.

Language: Английский

Citations

5

A brief review on aging and its combination with bibliometric analysis on cellular senescence elimination as part of anti aging strategies DOI
Indah Hartati, Vita Paramita,

Farikha Maharani

et al.

AIP conference proceedings, Journal Year: 2025, Volume and Issue: 3250, P. 030004 - 030004

Published: Jan. 1, 2025

Language: Английский

Citations

0

Marine-Based Bioactive Compounds in Healthcare and Wellness Industries DOI

Luis Fernando Flores,

Francisco Pardo, Carlos S. Osorio‐González

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0