Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 12, 2025
Significant
progress
has
been
made
in
regenerative
medicine
for
skin
repair
and
rejuvenation.
This
review
examines
core
technologies
including
stem
cell
therapy,
bioengineered
substitutes,
platelet-rich
plasma
(PRP),
exosome-based
therapies,
gene
editing
techniques
like
CRISPR.
These
methods
hold
promise
treating
a
range
of
conditions,
from
chronic
wounds
burns
to
age-related
changes
genetic
disorders.
Challenges
remain
optimizing
these
therapies
broader
accessibility
ensuring
long-term
safety
efficacy.
Advanced Engineering Materials,
Год журнала:
2024,
Номер
26(13)
Опубликована: Май 13, 2024
Bone
tissue
engineering
relies
on
crucial
scaffolds
for
formation
and
stem
cell
differentiation.
A
composite
scaffold
of
alginate‐gelatin
effectively
supports
these
processes.
This
study
aims
to
design
a
porous
hydrogel
assess
pore
size
effects
behavior,
focusing
morphology,
adhesion,
proliferation
in
distinct
osteogenic
environments.
Hydrogels
are
prepared
using
various
concentrations:
4%
alginate
6%
gelatin
(4A6G)
or
3%
5%
(3A5G),
cross‐linked
with
2%
CaCl2.
Pore
optimization
employs
simple
freezing
thawing
cycles.
Scanning
electron
microscopy
reveals
varying
sizes:
340
µm
±
30
4A6G
635
25
3A5G.
Stiffness
measurements
indicate
significant
differences:
≈26.3
kPa
0.6
KPa
21.6
0.2
Cell
interaction
studies
demonstrate
higher
adhesion
rates
larger‐pored
hydrogels.
Evaluation
bone
formation,
including
RT‐PCR,
ALP
activity,
ARS
staining,
reveal
superior
potential
the
3A5G
compared
4A6G.
In
conclusion,
(3%
gelatin)
holds
promise
regeneration
due
its
biodegradability
favorable
bone‐forming
properties.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(6), С. 145 - 145
Опубликована: Май 27, 2024
The
management
and
reconstruction
of
critical-sized
segmental
bone
defects
remain
a
major
clinical
challenge
for
orthopaedic
clinicians
surgeons.
In
particular,
regenerative
medicine
approaches
that
involve
incorporating
stem
cells
within
tissue
engineering
scaffolds
have
great
promise
fracture
management.
This
narrative
review
focuses
on
the
primary
components
engineering—stem
cells,
scaffolds,
microenvironment,
vascularisation—addressing
current
advances
translational
regulatory
challenges
in
landscape
cell
therapy
defects.
To
comprehensively
explore
this
research
area
offer
insights
future
treatment
options
surgery,
we
examined
latest
developments
advancements
engineering,
focusing
those
relevance
recent
years.
Finally,
present
forward-looking
perspective
using
Materials Advances,
Год журнала:
2024,
Номер
5(12), С. 4996 - 5024
Опубликована: Янв. 1, 2024
This
review
aims
to
provide
a
comprehensive
overview
of
the
current
trends,
advantages,
challenges,
and
future
directions
in
field
bionanocomposites
for
skin
tissue
repair
regeneration.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 12, 2025
Significant
progress
has
been
made
in
regenerative
medicine
for
skin
repair
and
rejuvenation.
This
review
examines
core
technologies
including
stem
cell
therapy,
bioengineered
substitutes,
platelet-rich
plasma
(PRP),
exosome-based
therapies,
gene
editing
techniques
like
CRISPR.
These
methods
hold
promise
treating
a
range
of
conditions,
from
chronic
wounds
burns
to
age-related
changes
genetic
disorders.
Challenges
remain
optimizing
these
therapies
broader
accessibility
ensuring
long-term
safety
efficacy.
