The next frontier in hemorrhagic management: A comprehensive review on development of natural polymer-based injectable hydrogels as promising hemostatic dressings

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 155033 - 155033

Published: Aug. 23, 2024

Language: Английский

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Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review

Materials, Journal Year: 2024, Volume and Issue: 17(19), P. 4792 - 4792

Published: Sept. 29, 2024

Hydrogels, known for their unique ability to retain large amounts of water, have emerged as pivotal materials in both tissue engineering and biosensing applications. This review provides an updated comprehensive examination cutting-edge hydrogel technologies multifaceted roles these fields. Initially, the chemical composition intrinsic properties natural synthetic hydrogels are discussed, highlighting biocompatibility biodegradability. The manuscript then probes into innovative scaffold designs fabrication techniques such 3D printing, electrospinning, self-assembly methods, emphasizing applications regenerating bone, cartilage, skin, neural tissues. In realm biosensing, hydrogels’ responsive nature is explored through integration optical, electrochemical, piezoelectric sensors. These sensors instrumental medical diagnostics glucose monitoring, pathogen detection, biomarker identification, well environmental industrial like pollution food quality monitoring. Furthermore, explores cross-disciplinary innovations, including use wearable devices, hybrid systems, potential personalized medicine. By addressing current challenges future directions, this aims underscore transformative impact advancing healthcare practices, thereby providing a vital resource researchers practitioners field.

Language: Английский

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Enhancing Osteogenic Potential in Bone Tissue Engineering: Optimizing Pore Size in Alginate–Gelatin Composite Hydrogels

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: 26(13)

Published: May 13, 2024

Bone tissue engineering relies on crucial scaffolds for formation and stem cell differentiation. A composite scaffold of alginate‐gelatin effectively supports these processes. This study aims to design a porous hydrogel assess pore size effects behavior, focusing morphology, adhesion, proliferation in distinct osteogenic environments. Hydrogels are prepared using various concentrations: 4% alginate 6% gelatin (4A6G) or 3% 5% (3A5G), cross‐linked with 2% CaCl2. Pore optimization employs simple freezing thawing cycles. Scanning electron microscopy reveals varying sizes: 340 µm ± 30 4A6G 635 25 3A5G. Stiffness measurements indicate significant differences: ≈26.3 kPa 0.6 KPa 21.6 0.2 Cell interaction studies demonstrate higher adhesion rates larger‐pored hydrogels. Evaluation bone formation, including RT‐PCR, ALP activity, ARS staining, reveal superior potential the 3A5G compared 4A6G. In conclusion, (3% gelatin) holds promise regeneration due its biodegradability favorable bone‐forming properties.

Language: Английский

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Towards Stem Cell Therapy for Critical-Sized Segmental Bone Defects: Current Trends and Challenges on the Path to Clinical Translation

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(6), P. 145 - 145

Published: May 27, 2024

The management and reconstruction of critical-sized segmental bone defects remain a major clinical challenge for orthopaedic clinicians surgeons. In particular, regenerative medicine approaches that involve incorporating stem cells within tissue engineering scaffolds have great promise fracture management. This narrative review focuses on the primary components engineering—stem cells, scaffolds, microenvironment, vascularisation—addressing current advances translational regulatory challenges in landscape cell therapy defects. To comprehensively explore this research area offer insights future treatment options surgery, we examined latest developments advancements engineering, focusing those relevance recent years. Finally, present forward-looking perspective using

Language: Английский

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Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of death worldwide and a major contributor to disability. Cardiac tissue engineering is promising approach for preventing functional damage or improving cardiac function after MI. We aimed introduce novel electroactive patch based on reduced graphene oxide-coated alginate scaffolds due behavior biomaterials regulate cell proliferation, biocompatibility, signal transition.The fabrication patches (ALG) coated with different concentrations oxide (rGO) using sodium hydrosulfite described here. The prepared were thoroughly tested their physicochemical properties cytocompatibility. ALG-rGO also antimicrobial antioxidant properties. Subcutaneous implantation in mice was used evaluate scaffolds' ability induce angiogenesis.The Young modulus increased by increasing rGO concentration from 92 ± 4.51 kPa ALG 431 4.89 ALG-rGO-4 (ALG 0.3% w/v rGO). tensile strength trended similarly. electrical conductivity calculated semi-conductive range (~ 10-4 S/m). Furthermore, when compared scaffolds, human umbilical vein endothelial cells (HUVECs) cultured demonstrated improved viability adhesion. Upregulation VEGFR2 expression at both mRNA protein levels confirmed that coating significantly boosted angiogenic capability against HUVECs. OD620 assay FE-SEM observation antibacterial Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes. showed samples possessed activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging UV-vis spectroscopy. Histological evaluations enhanced vascularization subcutaneous implantation.Our findings suggest scaffold accelerating repair damaged heart tissue.

Language: Английский

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