Neural Regeneration Research,
Год журнала:
2024,
Номер
20(7), С. 1883 - 1899
Опубликована: Июль 10, 2024
Various
nanoparticle-based
drug
delivery
systems
for
the
treatment
of
neurological
disorders
have
been
widely
studied.
However,
their
inability
to
cross
blood–brain
barrier
hampers
clinical
translation
these
therapeutic
strategies.
Liposomes
are
nanoparticles
composed
lipid
bilayers,
which
can
effectively
encapsulate
drugs
and
improve
across
into
brain
tissue
through
targeting
permeability.
Therefore,
they
potentially
treat
traumatic
nontraumatic
central
nervous
system
diseases.
In
this
review,
we
outlined
common
properties
preparation
methods
liposomes,
including
thin-film
hydration,
reverse-phase
evaporation,
solvent
injection
techniques,
detergent
removal
methods,
microfluidics
techniques.
Afterwards,
comprehensively
discussed
current
applications
liposomes
in
diseases,
such
as
Alzheimer’s
disease,
Parkinson’s
Huntington’s
amyotrophic
lateral
sclerosis,
injury,
spinal
cord
tumors.
Most
studies
related
still
laboratory
stage
not
yet
entered
trials.
Additionally,
application
practice
faces
challenges
stability,
efficiency,
safety.
proposed
development
strategies
further
promote
disease
research.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(26), С. 14498 - 14520
Опубликована: Июнь 17, 2024
Trimethylamine
N-oxide
(TMAO),
a
characteristic
nonprotein
nitrogen
compound,
is
widely
present
in
seafood,
which
exhibits
osmoregulatory
effects
for
marine
organisms
Midbrain
dopamine
(mDA)
neurons
comprise
diverse
cells
with
unique
innervation
targets
and
functions.
This
is
illustrated
by
the
selective
sensitivity
of
mDA
substantia
nigra
compacta
(SNc)
in
patients
Parkinson’s
disease,
while
those
ventral
tegmental
area
(VTA)
are
relatively
spared.
Here,
we
used
single
nuclei
RNA
sequencing
(snRNA-seq)
approximately
70,000
mouse
midbrain
to
build
a
high-resolution
atlas
neuron
diversity
at
molecular
level.
The
results
showed
that
differences
between
groups
could
best
be
understood
as
continuum
without
sharp
subtypes.
Thus,
assigned
several
‘territories’
‘neighborhoods’
within
shifting
gene
expression
landscape
where
boundaries
gradual
rather
than
discrete.
Based
on
enriched
patterns
these
territories
neighborhoods,
were
able
localize
them
adult
midbrain.
Moreover,
because
underlying
mechanisms
for
variable
sensitivities
pathological
insults
not
well
understood,
analyzed
surviving
after
partial
6-hydroxydopamine
(6-OHDA)
lesions
unravel
correlate
vulnerability
resilience.
Together,
this
provides
basis
further
studies
neurophysiological
role
health
disease.
Journal of Education Health and Sport,
Год журнала:
2025,
Номер
77, С. 56776 - 56776
Опубликована: Янв. 3, 2025
Introduction:
Omega-3
fatty
acids,
particularly
DHA
and
EPA,
are
crucial
for
brain
health.
Modern
diets,
often
lacking
in
omega-3,
highlight
their
importance
combating
cognitive
decline,
neurodegenerative
diseases,
mental
disorders.
Purpose
of
research:
This
study
explores
the
roles
omega-3
acids
health
functions,
including
mechanisms
action
potential
preventing
alleviating
diseases.
Materials
methods:
involves
a
comprehensive
review
scientific
literature
on
impact
functions.
The
search
was
conducted
using
PubMed
Google
Scholar,
focusing
peer-reviewed
articles,
clinical
trials,
meta-analyses
relevant
to
health,
outcomes.
Results
conclusions:
Research
shows
that
EPA
supplementation
can
significantly
improve
memory
learning,
especially
older
individuals
those
with
impairments.
Omega-3s
also
show
reducing
risk
diseases
like
Alzheimer's
through
anti-inflammatory
antioxidant
properties.
In
omega-3s
help
reduce
symptoms
depression
schizophrenia,
although
effectiveness
depends
dosage
ratio.
essential
Their
supplementation,
combined
cognitively
stimulating
activities,
offers
substantial
benefits,
aging
populations.
Further
research
is
needed
fully
understand
omega-3s'
mechanisms,
optimal
dosing,
use
treating
neurological
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 457 - 457
Опубликована: Янв. 27, 2025
Background:
Docosahexaenoic
Acid
(DHA)
is
an
extensively
used
nutrition
supplement
in
dairy
food
because
of
its
beneficial
effects
on
cognition.
To
find
effective
DHA
intervention
for
the
synapses
cortex
during
this
period,
study
aimed
to
use
targeted
lipidomics
evaluate
lipid
composition
prefrontal-cortex
(PFC)
tissue
different
interference
methods.
Methods:
Analyzed
samples
were
taken
from
interfering
feeding
Bama
pigs
(BPs)
(3
months)
fed
with
soybean
oil
(Group
B),
blended
M),
naturally
DHA-supplemented
milk
OM),
and
fish
(FO)
Y).
We
also
examined
protein
expression
levels
BDNF,
GAP43,
MBP.
Results:
The
analysis
identified
80
related
negative-ion
content
filtered
biomarker
lipids
PFC
tissue.
observed
significant
changes
between
group
Y
other
groups,
especially
phosphatidylcholine
(PC),
phosphatidylethanolamine
(PE),
phosphatidylinositol
(PI),
phosphatidylserine
(PS),
sphingomyelin
(SM).
same
observations
made
mRNA
expressions
transportation,
(PS)
synthetase,
synaptic
plasticity
tissues
including
CD36,
PTDSS1.
showed
that
metabolism
mode
FO
benefited
PFC,
PS
metabolism,
infants.
Conclusions:
results
highlight
further
prospects
mode,
which
provides
new
routes
studies
polyunsaturated-fatty-acid
(PUFA)
Marine Drugs,
Год журнала:
2025,
Номер
23(3), С. 91 - 91
Опубликована: Фев. 20, 2025
As
life
expectancy
rises
and
the
aging
population
grows,
Alzheimer’s
disease
(AD)
has
become
a
significant
global
health
concern.
AD
is
complex
neurodegenerative
disorder
with
an
unclear
etiology.
Current
hypotheses
primarily
focus
on
β-amyloid
(Aβ)
aggregation,
tau
protein
hyperphosphorylation,
neuroinflammation
as
key
pathological
processes.
Given
limited
efficacy
of
existing
therapeutic
strategies,
there
urgent
need
to
explore
novel
treatment
options.
Marine
natural
products
have
garnered
attention
due
their
unique
chemical
structures
diverse
bioactivities,
demonstrating
potential
for
multi-target
interventions
in
AD.
This
review
systematically
summarizes
roles
marine-derived
compounds,
including
polysaccharides,
carotenoids,
polyphenols,
modulating
Aβ
mitigating
pathology,
regulating
gut–brain
axis
dysfunction.
Furthermore,
challenges
current
research
are
discussed,
emphasis
improving
blood–brain
barrier
permeability
optimizing
drug
delivery
systems
facilitate
clinical
translation.
The Journal of Maternal-Fetal & Neonatal Medicine,
Год журнала:
2025,
Номер
38(1)
Опубликована: Фев. 23, 2025
Background
Neonatal
brain
injury
due
to
bilirubin
toxicity
presents
critical
need
for
effective
healing
treatments.
Docosahexaenoic
acid
(DHA),
having
neuroprotective
properties,
offers
potential
therapeutic
benefits
in
promoting
repair
and
recovery.
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Март 17, 2025
The
brain
is
rich
in
fatty
acids
(FAs),
with
polyunsaturated
(PUFAs),
such
as
docosahexaenoic
acid
(C22:6n-3,
DHA)
and
arachidonic
(C20:4n-6,
ARA),
the
former
predominantly
stored
form
of
phosphatidylcholine,
phosphatidyl
ethanolamine
(PE,
diacyl
plasma
phospholipid
proform),
phosphatidylserine
(PS),
while
latter
mainly
found
phosphoglycerides
(EPG)
contributes
to
constitute
most
phosphoglycerides.
When
required
by
body,
PUFAs
are
liberated
from
membrane
phospholipids
(either
directly
or
via
their
metabolites,
which
generated
a
series
enzymatic
reactions)
participate
various
cerebral
physiological
processes.
derivatives
play
crucial
roles
modulating
numerous
bodily
functions,
including
neuronal
signal
transmission,
neurogenesis,
neuroinflammation,
glucose
uptake
brain,
thereby
sustaining
fundamental
function.
Although
have
been
implicated
spectrum
neurological
disorders,
acute
injury
(TBI),
multiple
sclerosis
(MS),
neurodegenerative
diseases,
role
conditions
depression,
Alzheimer's
disease
(AD),
Parkinson's
(PD)
particularly
noteworthy.
These
disorders
closely
linked
critical
cognition,
memory,
inflammatory
Given
substantial
body
research
elucidating
involvement
pathogenesis
progression
these
this
review
will
specifically
concentrate
on
impact
within
contexts.
