Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders: drug stability, targeting efficiency, and safety DOI Creative Commons
Mingyu Zhang,

Chunyu Xiang,

Renrui Niu

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(7), P. 1883 - 1899

Published: July 10, 2024

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely studied. However, their inability to cross blood–brain barrier hampers clinical translation these therapeutic strategies. Liposomes are nanoparticles composed lipid bilayers, which can effectively encapsulate drugs and improve across into brain tissue through targeting permeability. Therefore, they potentially treat traumatic nontraumatic central nervous system diseases. In this review, we outlined common properties preparation methods liposomes, including thin-film hydration, reverse-phase evaporation, solvent injection techniques, detergent removal methods, microfluidics techniques. Afterwards, comprehensively discussed current applications liposomes in diseases, such as Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, injury, spinal cord tumors. Most studies related still laboratory stage not yet entered trials. Additionally, application practice faces challenges stability, efficiency, safety. proposed development strategies further promote disease research.

Language: Английский

Understanding of Alzheimer's Disease Pathophysiology for Therapeutic Implications of Natural Products as Neuroprotective Agents DOI

Sneh Prabha,

Arunabh Choudhury,

Asimul Islam

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102680 - 102680

Published: Feb. 1, 2025

Language: Английский

Citations

2
Trimethylamine N-Oxide in Aquatic Foods DOI
Xiao-Yue Li, Chengcheng Wang, Teruyoshi Yanagita

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(26), P. 14498 - 14520

Published: June 17, 2024

Trimethylamine N-oxide (TMAO), a characteristic nonprotein nitrogen compound, is widely present in seafood, which exhibits osmoregulatory effects for marine organisms

Language: Английский

Citations

6
Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model DOI Creative Commons
Behzad Yaghmaeian Salmani, Laura Lahti,

Linda Gillberg

et al.

eLife, Journal Year: 2024, Volume and Issue: 12

Published: April 8, 2024

Midbrain dopamine (mDA) neurons comprise diverse cells with unique innervation targets and functions. This is illustrated by the selective sensitivity of mDA substantia nigra compacta (SNc) in patients Parkinson’s disease, while those ventral tegmental area (VTA) are relatively spared. Here, we used single nuclei RNA sequencing (snRNA-seq) approximately 70,000 mouse midbrain to build a high-resolution atlas neuron diversity at molecular level. The results showed that differences between groups could best be understood as continuum without sharp subtypes. Thus, assigned several ‘territories’ ‘neighborhoods’ within shifting gene expression landscape where boundaries gradual rather than discrete. Based on enriched patterns these territories neighborhoods, were able localize them adult midbrain. Moreover, because underlying mechanisms for variable sensitivities pathological insults not well understood, analyzed surviving after partial 6-hydroxydopamine (6-OHDA) lesions unravel correlate vulnerability resilience. Together, this provides basis further studies neurophysiological role health disease.

Language: Английский

Citations

4
Omega-3 Fatty Acids: Key Players in Cognitive Function and Brain Health DOI Creative Commons

Wiktoria Wesołowska,

Emilia Bachoń,

Michalina Doligalska

et al.

Journal of Education Health and Sport, Journal Year: 2025, Volume and Issue: 77, P. 56776 - 56776

Published: Jan. 3, 2025

Introduction: Omega-3 fatty acids, particularly DHA and EPA, are crucial for brain health. Modern diets, often lacking in omega-3, highlight their importance combating cognitive decline, neurodegenerative diseases, mental disorders. Purpose of research: This study explores the roles omega-3 acids health functions, including mechanisms action potential preventing alleviating diseases. Materials methods: involves a comprehensive review scientific literature on impact functions. The search was conducted using PubMed Google Scholar, focusing peer-reviewed articles, clinical trials, meta-analyses relevant to health, outcomes. Results conclusions: Research shows that EPA supplementation can significantly improve memory learning, especially older individuals those with impairments. Omega-3s also show reducing risk diseases like Alzheimer's through anti-inflammatory antioxidant properties. In omega-3s help reduce symptoms depression schizophrenia, although effectiveness depends dosage ratio. essential Their supplementation, combined cognitively stimulating activities, offers substantial benefits, aging populations. Further research is needed fully understand omega-3s' mechanisms, optimal dosing, use treating neurological

Language: Английский

Citations

0
Fucoxanthin promotes the conversion efficiency of alpha-linolenic acid in feeding to docosahexaenoic acid in quail egg yolk DOI
Wenlei Guo,

Shuai-Shuai Fu,

Xiaoyue Li

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142915 - 142915

Published: Jan. 15, 2025

Language: Английский

Citations

0
Lipidomics Analysis Reveals the Effects of Docosahexaenoic Acid from Different Sources on Prefrontal-Cortex Synaptic Plasticity DOI Open Access
Zhongwei He, Wei Xiong, Yue Yang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 457 - 457

Published: Jan. 27, 2025

Background: Docosahexaenoic Acid (DHA) is an extensively used nutrition supplement in dairy food because of its beneficial effects on cognition. To find effective DHA intervention for the synapses cortex during this period, study aimed to use targeted lipidomics evaluate lipid composition prefrontal-cortex (PFC) tissue different interference methods. Methods: Analyzed samples were taken from interfering feeding Bama pigs (BPs) (3 months) fed with soybean oil (Group B), blended M), naturally DHA-supplemented milk OM), and fish (FO) Y). We also examined protein expression levels BDNF, GAP43, MBP. Results: The analysis identified 80 related negative-ion content filtered biomarker lipids PFC tissue. observed significant changes between group Y other groups, especially phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), sphingomyelin (SM). same observations made mRNA expressions transportation, (PS) synthetase, synaptic plasticity tissues including CD36, PTDSS1. showed that metabolism mode FO benefited PFC, PS metabolism, infants. Conclusions: results highlight further prospects mode, which provides new routes studies polyunsaturated-fatty-acid (PUFA)

Language: Английский

Citations

0
The Advancements of Marine Natural Products in the Treatment of Alzheimer’s Disease: A Study Based on Cell and Animal Experiments DOI Creative Commons
Chunbo Jia, Jian Chai,

Shenyun Zhang

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(3), P. 91 - 91

Published: Feb. 20, 2025

As life expectancy rises and the aging population grows, Alzheimer’s disease (AD) has become a significant global health concern. AD is complex neurodegenerative disorder with an unclear etiology. Current hypotheses primarily focus on β-amyloid (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation as key pathological processes. Given limited efficacy of existing therapeutic strategies, there urgent need to explore novel treatment options. Marine natural products have garnered attention due their unique chemical structures diverse bioactivities, demonstrating potential for multi-target interventions in AD. This review systematically summarizes roles marine-derived compounds, including polysaccharides, carotenoids, polyphenols, modulating Aβ mitigating pathology, regulating gut–brain axis dysfunction. Furthermore, challenges current research are discussed, emphasis improving blood–brain barrier permeability optimizing drug delivery systems facilitate clinical translation.

Language: Английский

Citations

0
Evaluating the healing effects of docosahexaenoic acid in neonates with bilirubin-induced brain injury DOI Creative Commons
Peng Shao, Yue Tang, Yuxia Li

et al.

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2025, Volume and Issue: 38(1)

Published: Feb. 23, 2025

Background Neonatal brain injury due to bilirubin toxicity presents critical need for effective healing treatments. Docosahexaenoic acid (DHA), having neuroprotective properties, offers potential therapeutic benefits in promoting repair and recovery.

Language: Английский

Citations

0
The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System DOI Creative Commons
Jiajia Tian, Yating Zhang, Xudong Zhao

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 17, 2025

The brain is rich in fatty acids (FAs), with polyunsaturated (PUFAs), such as docosahexaenoic acid (C22:6n-3, DHA) and arachidonic (C20:4n-6, ARA), the former predominantly stored form of phosphatidylcholine, phosphatidyl ethanolamine (PE, diacyl plasma phospholipid proform), phosphatidylserine (PS), while latter mainly found phosphoglycerides (EPG) contributes to constitute most phosphoglycerides. When required by body, PUFAs are liberated from membrane phospholipids (either directly or via their metabolites, which generated a series enzymatic reactions) participate various cerebral physiological processes. derivatives play crucial roles modulating numerous bodily functions, including neuronal signal transmission, neurogenesis, neuroinflammation, glucose uptake brain, thereby sustaining fundamental function. Although have been implicated spectrum neurological disorders, acute injury (TBI), multiple sclerosis (MS), neurodegenerative diseases, role conditions depression, Alzheimer's disease (AD), Parkinson's (PD) particularly noteworthy. These disorders closely linked critical cognition, memory, inflammatory Given substantial body research elucidating involvement pathogenesis progression these this review will specifically concentrate on impact within contexts.

Language: Английский

Citations

0
Investigate the protective effects of eicosapentaenoic acid in human astrocytes of oxidative stress damage and explore its underlying mechanisms DOI
Che‐Sheng Chu, Ying-Tso Chen, Wei‐Chih Sun

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 15, 2025

Language: Английский

Citations

0