Exploring the Potential of Crassostrea nippona Hydrolysates as Dietary Supplements for Mitigating Dexamethasone-Induced Muscle Atrophy in C2C12 Cells DOI Creative Commons

M. J. M. S. Kurera,

D. P. Nagahawatta, N. M. Liyanage

и другие.

Marine Drugs, Год журнала: 2024, Номер 22(3), С. 113 - 113

Опубликована: Фев. 28, 2024

Muscle atrophy is a detrimental and injurious condition that leads to reduced skeletal muscle mass disruption of protein metabolism. Oyster (Crassostrea nippona) famous commonly consumed shellfish in East Asia has become popular dietary choice worldwide. The current investigation evaluated the efficacy C. nippona against atrophy, which severe health issue. Mammalian muscles are primarily responsible for efficient metabolism, energy consumption, body movements. proteins regulate hypertrophy involved growth. extracts were enzymatically hydrolyzed using alcalase (AOH), flavourzyme (FOH), protamex (POH) evaluate their mitigating dexamethasone-induced damage C2C12 cells vitro. AOH exhibited notable cell proliferative abilities, promoting dose-dependent myotube formation. These results further solidified by expression analysis. Western blot gene analysis via RT-qPCR demonstrated downregulated MuRF-1, Atrogin, Smad 2/3, Foxo-3a, while upregulating myogenin, MyoD, myosin heavy chain expression, mTOR, key components ubiquitin–proteasome mTOR signaling pathways. Finally, this study suggests holds promise alleviating vitro, offering insights developing functional foods targeting conditions akin sarcopenia.

Язык: Английский

Extraction methods, structural features and bioactivity diversity of polysaccharides from the genus Chrysanthemum: A review DOI
Peiling Yu,

Yue Zhou,

Jia Liu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139423 - 139423

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

3

Extraction, purification, structural characteristics, biological activities, modifications, and applications from Hericium erinaceus polysaccharides: A review DOI
Ben Niu, Lei Zhang, Bodong Chen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138932 - 138932

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

3

Extraction, purification, structural characterization, and biological activity of polysaccharides from Aralia: A review DOI
Xiaolan Liu,

Zhen Zang,

Rong Ji

и другие.

Fitoterapia, Год журнала: 2025, Номер 181, С. 106379 - 106379

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0

Exploring the potential of Fucoidan from Laminaria japonica: A comprehensive review of its biological activities and benefits for human DOI
Hui Wan, Yuxin Zhang, Zhicheng Gao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142297 - 142297

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Research advance in the preparation techniques, structural characteristics, bioactivities and potential applications of Cassia obtusifolia polysaccharides: A systematic review DOI
Mengjie Chen,

Yuan Sun,

Linfei Zhao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 311, С. 143732 - 143732

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Comparison on chemical, structural, thermal, functional and antioxidant properties of polysaccharides and phenolics co-extracted from mangosteen (Garcinia mangostana Linn) peels by different eco-friendly hybrid technologies DOI Creative Commons
Nhu Bich, Nguyen Ngoc Thanh Tien, Linh Tran Khanh Vu

и другие.

Journal of Agriculture and Food Research, Год журнала: 2024, Номер 18, С. 101507 - 101507

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

2

Novel extraction of bioactive compounds from algae using green solvent: principles, applications, and future perspectives. DOI Creative Commons
Tan Phat Vo, Dinh Quan Nguyen,

Thai Anh Thi Ho

и другие.

Journal of Agriculture and Food Research, Год журнала: 2024, Номер unknown, С. 101535 - 101535

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

2

Exploring the Potential of Crassostrea nippona Hydrolysates as Dietary Supplements for Mitigating Dexamethasone-Induced Muscle Atrophy in C2C12 Cells DOI Creative Commons

M. J. M. S. Kurera,

D. P. Nagahawatta, N. M. Liyanage

и другие.

Marine Drugs, Год журнала: 2024, Номер 22(3), С. 113 - 113

Опубликована: Фев. 28, 2024

Muscle atrophy is a detrimental and injurious condition that leads to reduced skeletal muscle mass disruption of protein metabolism. Oyster (Crassostrea nippona) famous commonly consumed shellfish in East Asia has become popular dietary choice worldwide. The current investigation evaluated the efficacy C. nippona against atrophy, which severe health issue. Mammalian muscles are primarily responsible for efficient metabolism, energy consumption, body movements. proteins regulate hypertrophy involved growth. extracts were enzymatically hydrolyzed using alcalase (AOH), flavourzyme (FOH), protamex (POH) evaluate their mitigating dexamethasone-induced damage C2C12 cells vitro. AOH exhibited notable cell proliferative abilities, promoting dose-dependent myotube formation. These results further solidified by expression analysis. Western blot gene analysis via RT-qPCR demonstrated downregulated MuRF-1, Atrogin, Smad 2/3, Foxo-3a, while upregulating myogenin, MyoD, myosin heavy chain expression, mTOR, key components ubiquitin–proteasome mTOR signaling pathways. Finally, this study suggests holds promise alleviating vitro, offering insights developing functional foods targeting conditions akin sarcopenia.

Язык: Английский

Процитировано

1