Exploring the Potential of Crassostrea nippona Hydrolysates as Dietary Supplements for Mitigating Dexamethasone-Induced Muscle Atrophy in C2C12 Cells DOI Creative Commons

M. J. M. S. Kurera,

D. P. Nagahawatta, N. M. Liyanage

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 113 - 113

Published: Feb. 28, 2024

Muscle atrophy is a detrimental and injurious condition that leads to reduced skeletal muscle mass disruption of protein metabolism. Oyster (Crassostrea nippona) famous commonly consumed shellfish in East Asia has become popular dietary choice worldwide. The current investigation evaluated the efficacy C. nippona against atrophy, which severe health issue. Mammalian muscles are primarily responsible for efficient metabolism, energy consumption, body movements. proteins regulate hypertrophy involved growth. extracts were enzymatically hydrolyzed using alcalase (AOH), flavourzyme (FOH), protamex (POH) evaluate their mitigating dexamethasone-induced damage C2C12 cells vitro. AOH exhibited notable cell proliferative abilities, promoting dose-dependent myotube formation. These results further solidified by expression analysis. Western blot gene analysis via RT-qPCR demonstrated downregulated MuRF-1, Atrogin, Smad 2/3, Foxo-3a, while upregulating myogenin, MyoD, myosin heavy chain expression, mTOR, key components ubiquitin–proteasome mTOR signaling pathways. Finally, this study suggests holds promise alleviating vitro, offering insights developing functional foods targeting conditions akin sarcopenia.

Language: Английский

Extraction methods, structural features and bioactivity diversity of polysaccharides from the genus Chrysanthemum: A review DOI
Peiling Yu,

Yue Zhou,

Jia Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139423 - 139423

Published: Jan. 1, 2025

Language: Английский

Citations

3
Extraction, purification, structural characterization, and biological activity of polysaccharides from Aralia: A review DOI
Xiaolan Liu,

Zhen Zang,

Rong Ji

et al.

Fitoterapia, Journal Year: 2025, Volume and Issue: 181, P. 106379 - 106379

Published: Jan. 6, 2025

Language: Английский

Citations

0
Exploring the potential of Fucoidan from Laminaria japonica: A comprehensive review of its biological activities and benefits for human DOI
Hui Wan, Yuxin Zhang, Zhicheng Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142297 - 142297

Published: March 1, 2025

Language: Английский

Citations

0
Research advance in the preparation techniques, structural characteristics, bioactivities and potential applications of Cassia obtusifolia polysaccharides: A systematic review DOI
Mengjie Chen,

Yuan Sun,

Linfei Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143732 - 143732

Published: May 1, 2025

Language: Английский

Citations

0
Novel extraction of bioactive compounds from algae using green solvent: principles, applications, and future perspectives. DOI Creative Commons
Tan Phat Vo, Dinh Quan Nguyen,

Thai Anh Thi Ho

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 101535 - 101535

Published: Nov. 1, 2024

Language: Английский

Citations

3
Extraction, purification, structural characteristics, biological activities, modifications, and applications from Hericium erinaceus polysaccharides: A review DOI
Ben Niu, Lei Zhang, Bodong Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138932 - 138932

Published: Dec. 1, 2024

Language: Английский

Citations

3
Comparison on chemical, structural, thermal, functional and antioxidant properties of polysaccharides and phenolics co-extracted from mangosteen (Garcinia mangostana Linn) peels by different eco-friendly hybrid technologies DOI Creative Commons
Nhu Bich, Nguyen Ngoc Thanh Tien, Linh Tran Khanh Vu

et al.

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: 18, P. 101507 - 101507

Published: Nov. 8, 2024

Language: Английский

Citations

2
Exploring the Potential of Crassostrea nippona Hydrolysates as Dietary Supplements for Mitigating Dexamethasone-Induced Muscle Atrophy in C2C12 Cells DOI Creative Commons

M. J. M. S. Kurera,

D. P. Nagahawatta, N. M. Liyanage

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 113 - 113

Published: Feb. 28, 2024

Muscle atrophy is a detrimental and injurious condition that leads to reduced skeletal muscle mass disruption of protein metabolism. Oyster (Crassostrea nippona) famous commonly consumed shellfish in East Asia has become popular dietary choice worldwide. The current investigation evaluated the efficacy C. nippona against atrophy, which severe health issue. Mammalian muscles are primarily responsible for efficient metabolism, energy consumption, body movements. proteins regulate hypertrophy involved growth. extracts were enzymatically hydrolyzed using alcalase (AOH), flavourzyme (FOH), protamex (POH) evaluate their mitigating dexamethasone-induced damage C2C12 cells vitro. AOH exhibited notable cell proliferative abilities, promoting dose-dependent myotube formation. These results further solidified by expression analysis. Western blot gene analysis via RT-qPCR demonstrated downregulated MuRF-1, Atrogin, Smad 2/3, Foxo-3a, while upregulating myogenin, MyoD, myosin heavy chain expression, mTOR, key components ubiquitin–proteasome mTOR signaling pathways. Finally, this study suggests holds promise alleviating vitro, offering insights developing functional foods targeting conditions akin sarcopenia.

Language: Английский

Citations

1