Antitumor activity of edible fishes (Channa striata and Anabas testudineus) and gastropods (Helix aspersa and Pila virens) rudimentary mucus against HT-29 cell line and its biochemical properties
Elumalai Devan,
Hemavathi Maduraiveeran,
Kavitha Raja
и другие.
The Journal of Basic and Applied Zoology,
Год журнала:
2025,
Номер
86(1)
Опубликована: Янв. 11, 2025
Abstract
Background
The
mucus
from
fish
and
gastropods
contains
a
wide
range
of
bioactive
molecules
with
biomedical
properties.
were
collected
Oragadam
lake,
Kanchipuram
district,
Tamil
Nadu,
India.
In
this
study,
we
wanted
to
examine
the
anticancer
potential
mucus.
biochemical
components
crude
screened.
Results
analysis
showed
that
Anabas
testudineus
Pila
virens
contained
high
level
carbohydrates
(2.8
1.5
mg/ml),
Channa
striata
lipids
(0.9
Helix
aspersa
protein
(1.3
mg/ml).
results
morphological
variations
in
HT-29
cells
upon
treatment
Upon
24
h
gestation,
frozen
began
shrink
seem
round
shape.
Using
MTT
assay,
extract
was
evaluated
for
its
properties
against
human
colon
cancer
cell
line
(HT
29).
inhibitory
concentration
(IC50)
determined
at
100
µg/ml
after
h.
specific
staining
techniques;
fluorescent
microscopy
utilized
morphology
early
late
apoptotic
stages.
Propidium
iodide
nuclear
damage
followed
by
DNA
damage.
This
rudimentary
could
prompt
death
increased
number
fragments
concentration,
respectively.
Conclusion
study
edible
or
commercially
important
gastropod
have
activity
cells.
Язык: Английский
Compositional and nutritional insights into Mediterranean sea cucumbers: A study on Holothuria polii and Holothuria tubulosa from Southern Italy
Journal of Food Composition and Analysis,
Год журнала:
2025,
Номер
141, С. 107315 - 107315
Опубликована: Фев. 1, 2025
Язык: Английский
Sulfated Glycosaminoglycan CIP-3 from Edible Marine Octopus Cistopus indicus: A Promising Bioactive with Anti-Hyperglycemic Effects in 3T3-L1 Adipocyte Cells for Functional Food Applications
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106234 - 106234
Опубликована: Фев. 1, 2025
Язык: Английский
Identification and Characterization of a Novel GAPDH‐Derived Antimicrobial Peptide From Jellyfish
Journal of Peptide Science,
Год журнала:
2025,
Номер
31(4)
Опубликована: Март 5, 2025
Marine
organisms
serve
as
a
rich
source
of
bioactive
natural
compounds,
including
antimicrobial
agents.
Jellyfish,
which
are
ancient
marine
invertebrates
with
hundreds
millions
years
evolutionary
history,
have
been
in
continuous
contact
diverse
array
pathogenic
microorganisms
from
seawater,
may
give
rise
to
distinctive
innate
immune
system
and
related
defensive
molecules.
However,
it
is
difficult
inefficient
isolate
active
ingredients
directly
jellyfish
for
enrichment,
though
few
jellyfish-sourced
peptides
(AMPs)
reported.
In
this
study,
we
utilized
transcriptomic
big
data
bioinformatic
tools
dig
deeper
into
potential
components
jellyfish,
identified
new
AMP
JFP-2826
Rhopilema
esculentum.
The
20-mer
peptide
exhibited
an
alpha-helix
structure
showed
activity
against
selected
bacterial
strains;
more
importantly,
demonstrated
good
selectivity
marine-specific
Vibrio
vulnificus.
Sequence
analysis
the
full-length
protein
revealed
that
derived
housekeeping
gene
glyceraldehyde-3-phosphate
dehydrogenase
(GAPDH),
probably
produced
through
enzymatic
cleavage
N-terminal
fragment.
This
suggests
GAPDH
might
newly
discovered
antimicrobial-related
function
conducted
by
releasing
JFP-2826-like
cryptic
peptides.
can
be
subjected
further
structural
modifications
optimizations
potentially
become
potent
lead
development
novel
drugs
treating
infections
pathogens.
Язык: Английский
From Fins to Furs: Unlocking the therapeutic potential of animal-derived bioactives for wound care
Medicine in Drug Discovery,
Год журнала:
2025,
Номер
unknown, С. 100206 - 100206
Опубликована: Март 1, 2025
Язык: Английский
Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy
International Journal of Translational Medicine,
Год журнала:
2024,
Номер
4(4), С. 740 - 781
Опубликована: Дек. 6, 2024
The
increase
in
cancer
incidence
recent
years
necessitates
urgent
exploration
of
novel
and
alternative
sources
natural
bioactives
for
targeted
therapy.
Approximately
75%
the
Earth’s
surface
is
covered
by
oceans,
which
are
thought
to
harbor
untapped
physiologically
active
compounds
with
potential
efficacy
against
cancer.
Recently,
a
growing
focus
has
been
on
isolating
investigating
bioactive
derived
from
marine
sources.
Bioactive
metabolites
diverse
chemical
structures,
isolated
various
species
such
as
algae,
mollusks,
actinomycetes,
demonstrate
wide
range
cancers.
To
our
knowledge,
this
one
articles
that
reviewed
papers
application
marine-derived
This
study
aims
showcase
some
most
current
developments
therapy
have
identified
Язык: Английский
Understanding the structure and function of mollusc toxins: a gateway to novel biomedical applications
Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 3
Опубликована: Июль 4, 2024
Mollusc
toxins,
which
are
diverse
bioactive
substances
generated
by
marine
invertebrates,
present
significant
potential
for
biomedical
advancements.
These
structurally
including
conotoxins
and
tetrodotoxin,
specifically
target
physiological
processes
serve
as
blueprints
new
therapeutic
agents.
High-resolution
methods
have
clarified
their
structures,
offering
valuable
insights
into
mechanisms
of
action.
Functional
research
has
broadened
our
comprehension
biological
discovered
drug
targets.
Additionally,
the
ecological
roles
these
toxins
highlight
importance
in
ecosystems.
Ongoing
mollusc
will
deepen
understanding
biodiversity
aid
developing
innovative
treatments.
Язык: Английский