F16 Hybrids Derived from Steviol or Isosteviol Are Accumulated in the Mitochondria of Tumor Cells and Overcome Drug Resistance
Molecules,
Год журнала:
2024,
Номер
29(2), С. 381 - 381
Опубликована: Янв. 12, 2024
Steviol
and
isosteviol
were
prepared
from
the
commercially
available
sweetener
stevioside
converted
into
lipophilic
F16
hybrids.
Their
cytotoxicity
was
determined
in
SRB
assays
showed
to
depend
on
both
substitution
pattern
of
aromatic
substituent
as
well
spacer
length.
Therefore,
compound
Язык: Английский
From Traditional Efficacy to Drug Design: A Review of Astragali Radix
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 413 - 413
Опубликована: Март 14, 2025
Astragali
Radix
(AR),
a
traditional
Chinese
herbal
medicine,
is
derived
from
the
dried
roots
of
Astragalus
membranaceus
(Fisch.)
Bge.
var.
mongholicus
(Bge.)
Hsiao
(A.
mongholicus,
AMM)
or
Bge
membranaceus,
AM).
According
to
medicine
(TCM)
theory,
AR
believed
tonify
qi,
elevate
yang,
consolidate
body’s
surface
reduce
sweating,
promote
diuresis
and
swelling,
generate
body
fluids,
nourish
blood.
It
has
been
widely
used
treat
general
weakness
chronic
illnesses
improve
overall
vitality.
Extensive
research
identified
various
medicinal
properties
AR,
including
anti-tumor,
antioxidant,
cardiovascular-protective,
immunomodulatory,
anti-inflammatory,
anti-diabetic,
neuroprotective
effects.
With
advancements
in
technology,
methods
such
as
computer-aided
drug
design
(CADD)
artificial
intelligence
(AI)
are
increasingly
being
applied
development
TCM.
This
review
summarizes
progress
on
over
past
decades,
providing
comprehensive
overview
its
efficacy,
botanical
characteristics,
distribution,
chemical
constituents,
phytochemistry.
aims
enhance
researchers’
understanding
pharmaceutical
potential,
thereby
facilitating
further
utilization.
Язык: Английский
Toxic Effects of Penetrating Cations
Membranes,
Год журнала:
2023,
Номер
13(10), С. 841 - 841
Опубликована: Окт. 22, 2023
As
mitochondria
are
negatively
charged
organelles,
penetrating
cations
used
as
parts
of
chimeric
molecules
to
deliver
specific
compounds
into
mitochondria.
In
other
words,
they
electrophilic
carriers
for
such
chemical
moieties
antioxidants,
dyes,
etc.,
transfer
them
inside
However,
unmodified
affect
different
aspects
cellular
physiology
well.
this
review,
we
have
attempted
summarise
the
data
about
side
effects
commonly
natural
(e.g.,
berberine)
and
artificial
tetraphenylphosphonium,
rhodamine,
methylene
blue)
on
physiology.
For
instance,
it
was
shown
that
types
can
(1)
facilitate
proton
transport
across
membranes;
(2)
react
with
redox
groups
respiratory
chain;
(3)
induce
DNA
damage;
(4)
interfere
pleiotropic
drug
resistance;
(5)
disturb
membrane
integrity;
(6)
inhibit
enzymes.
Also,
products
biodegradation
be
toxic.
accumulate
in
mitochondria,
their
toxicity
is
mostly
due
mitochondrial
damage.
Mitochondria
from
certain
cancer
cells
appear
especially
sensitive
cations.
Here,
discuss
molecular
mechanisms
toxic
anti-cancer
activity
Язык: Английский
The Effect of 20-Hydroxyecdysone on the Functioning of Isolated Mouse Skeletal Muscle Mitochondria
Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology,
Год журнала:
2024,
Номер
18(2), С. 127 - 135
Опубликована: Июнь 1, 2024
Язык: Английский
Synthesis and comparative analysis of the cytotoxicity and mitochondrial effects of triphenylphosphonium and F16 maslinic and corosolic acid hybrid derivatives
Steroids,
Год журнала:
2024,
Номер
209, С. 109471 - 109471
Опубликована: Июль 11, 2024
Язык: Английский
Effect of TRO19622 (Olesoxime) on the Functional Activity of Isolated Mitochondria and Cell Viability
Биофизика,
Год журнала:
2024,
Номер
69(4), С. 737 - 746
Опубликована: Сен. 27, 2024
Язык: Английский
The Effect of 20-Hydroxyecdysone on the Functioning of isolated Mouse Skeletal Muscle Mitochondria
Биологические мембраны Журнал мембранной и клеточной биологии,
Год журнала:
2024,
Номер
41(3), С. 233 - 242
Опубликована: Июль 29, 2024
Язык: Английский
The Effect of TRO19622 (Olesoxime) on the Functional Activity of Isolated Mitochondria and Cell Viability
BIOPHYSICS,
Год журнала:
2024,
Номер
69(4), С. 630 - 638
Опубликована: Авг. 1, 2024
Язык: Английский
Synthesis and Cytotoxic Activity of Conjugates of Mitochondrial-Directed Cationic Compound F16 with Ursane-Structure Triterpenic Acids Containing a Polyhydroxylated A-ring
Опубликована: Ноя. 15, 2023
We
chemically
linked
corosolic
and
asiatic
acids
a
synthetic
polyoxygenated
analogue
of
ursolic
acid
via
an
alkyl
linker
to
the
cationic
mitochondrial
targeting
compound
F16
(4-(1H-indole-3-ylvinyl)-N-methylpyridinium
iodide).
The
conjugates
were
tested
for
cytotoxic
activity
against
two
human
lung
adenocarcinoma
cell
lines,
H1299
A549,
non-cancerous
mouse
embryonic
fibroblast
cells.
results
showed
that
conjugation
triterpene
with
terminal
fragment
in
C-28
side
chain
enhanced
cytotoxicity
(30–35
fold)
compared
original
natural
acid.
However,
presence
hydroxyl
or
acetyl
functions
A-ring
resulted
significant
decrease
their
structural
analogue,
derivative
Язык: Английский