Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

Antibiotics, Год журнала: 2020, Номер 9(4), С. 170 - 170

Опубликована: Апрель 10, 2020

Infectious diseases that are caused by bacteria an important cause of mortality and morbidity in all regions the world. Bacterial drug resistance has grown last decades, but rate discovery new antibiotics steadily decreased. Therefore, search for effective antibacterial agents become a top priority. The plant kingdom seems to be deep well searching novel antimicrobial agents. This is due many attractive features plants: they readily available cheap, extracts or compounds from sources often demonstrate high-level activity against pathogens, rarely have severe side effects. huge variety plant-derived provides very diverse chemical structures may supply both mechanisms action provide us with targets within bacterial cell. In addition, rapid development modern biotechnologies opens up way obtaining bioactive environmentally friendly low-toxic conditions. this short review, we ask question: do derived plants chance panacea infectious "post-antibiotics era".

Язык: Английский

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Biostimulants for Plant Growth and Mitigation of Abiotic Stresses: A Metabolomics Perspective

Metabolites, Год журнала: 2020, Номер 10(12), С. 505 - 505

Опубликована: Дек. 10, 2020

Adverse environmental conditions due to climate change, combined with declining soil fertility, threaten food security. Modern agriculture is facing a pressing situation where novel strategies must be developed for sustainable production and Biostimulants, conceptually defined as non-nutrient substances or microorganisms the ability promote plant growth health, represent potential provide economically favorable solutions that could introduce approaches improve agricultural practices crop productivity. Current knowledge phenotypic observations suggest biostimulants potentially function in regulating modifying physiological processes plants growth, alleviate stresses, quality yield. However, successfully develop biostimulant-based formulations programs, understanding biostimulant-plant interactions, at molecular, cellular levels, prerequisite. Metabolomics, multidisciplinary omics science, offers unique opportunities predictively decode mode of action on plants, identify signatory markers biostimulant action. Thus, this review intends highlight current scientific efforts gaps research industry, context promotion stress responses. The firstly revisits models have been elucidated describe molecular machinery employed by coping stresses. Furthermore, definitions, claims applications are pointed out, also indicating lack biological basis accurately postulate mechanisms biostimulants. articulates briefly key aspects metabolomics workflow (potential) science industry.

Язык: Английский

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A Comprehensive Review on the Biological, Agricultural and Pharmaceutical Properties of Secondary Metabolites Based-Plant Origin

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3266 - 3266

Опубликована: Фев. 7, 2023

Natural products are compounds produced by living organisms and can be divided into two main categories: primary (PMs) secondary metabolites (SMs). Plant PMs crucial for plant growth reproduction since they directly involved in cell processes, whereas SMs organic substances defense resistance. three groups: terpenoids, phenolics nitrogen-containing compounds. The contain a variety of biological capabilities that used as flavoring agents, food additives, plant-disease control, strengthen defenses against herbivores and, additionally, it help cells to better adapted the physiological stress response. current review is mainly focusing on certain key elements related significance, biosynthesis, classification, biochemical characterization medical/pharmaceutical uses major categories SMs. In addition, usefulness controlling diseases, boosting resistance potential natural, safe, eco-friendly substitutes chemosynthetic pesticides were also reported this review.

Язык: Английский

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Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

Molecular Plant, Год журнала: 2022, Номер 16(1), С. 43 - 63

Опубликована: Сен. 16, 2022

Язык: Английский

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Recent advances in proteomics and metabolomics in plants

Molecular Horticulture, Год журнала: 2022, Номер 2(1)

Опубликована: Июль 23, 2022

Over the past decade, systems biology and plant-omics have increasingly become main stream in plant research. New developments mass spectrometry bioinformatics tools, methodological schema to integrate multi-omics data leveraged recent advances proteomics metabolomics. These progresses are driving a rapid evolution field of research, greatly facilitating our understanding mechanistic aspects metabolisms interactions plants with their external environment. Here, we review MS-based metabolomics tools workflows special focus on applications research using several case studies related stress response, gene/protein function characterization, metabolic signaling pathways exploration, natural product discovery. We also present projection concerning future perspectives development including challenges for system biology. This is intended provide readers an overview how advanced MS technology, integrated application can be used advance

Язык: Английский

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Recent advances in the role of mass spectrometry in the analysis of food: a review

Journal of Food Measurement & Characterization, Год журнала: 2024, Номер 18(6), С. 4272 - 4287

Опубликована: Март 15, 2024

Язык: Английский

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Revealing the hidden world of soil microbes: Metagenomic insights into plant, bacteria, and fungi interactions for sustainable agriculture and ecosystem restoration

Microbiological Research, Год журнала: 2024, Номер 285, С. 127764 - 127764

Опубликована: Май 15, 2024

Язык: Английский

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Phenolics from Medicinal and Aromatic Plants: Characterisation and Potential as Biostimulants and Bioprotectants

Molecules, Год журнала: 2021, Номер 26(21), С. 6343 - 6343

Опубликована: Окт. 20, 2021

Biostimulants and bioprotectants are derived from natural sources can enhance crop growth protect crops pests pathogens, respectively. They have attracted much attention in the past few decades contribute to a more sustainable eco-friendly agricultural system. Despite not having been explored extensively, plant extracts their component secondary metabolites, including phenolic compounds shown biostimulant effects on plants, enhancement of attributes yield, as well bioprotectant effects, antimicrobial, insecticidal, herbicidal nematicidal effects. Medicinal aromatic plants widely distributed all over world abundant compounds. This paper reviews characterisation medicinal brief overview extraction, phytochemical screening methods analysis. The second part review highlights potential for use biostimulants agriculture some challenges related use.

Язык: Английский

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Plants Metabolome Study: Emerging Tools and Techniques

Plants, Год журнала: 2021, Номер 10(11), С. 2409 - 2409

Опубликована: Ноя. 8, 2021

Metabolomics is now considered a wide-ranging, sensitive and practical approach to acquire useful information on the composition of metabolite pool present in any organism, including plants. Investigating metabolomic regulation plants essential understand their adaptation, acclimation defense responses environmental stresses through production numerous metabolites. Moreover, metabolomics can be easily applied for phenotyping plants; thus, it has great potential used genome editing programs develop superior next-generation crops. This review describes recent analytical tools techniques available study metabolome, along with significance sample preparation using targeted non-targeted methods. Advanced tools, like gas chromatography-mass spectrometry (GC-MS), liquid chromatography mass-spectroscopy (LC-MS), capillary electrophoresis-mass (CE-MS), fourier transform ion cyclotron resonance-mass (FTICR-MS) matrix-assisted laser desorption/ionization (MALDI), mobility (IMS) nuclear magnetic resonance (NMR) have speed up precise metabolic profiling Further, we provide complete overview bioinformatics plant metabolome database that utilized advance our knowledge biology.

Язык: Английский

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Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Analytical and Bioanalytical Chemistry, Год журнала: 2021, Номер 414(2), С. 759 - 789

Опубликована: Авг. 25, 2021

Abstract Metabolomics refers to the large-scale detection, quantification, and analysis of small molecules (metabolites) in biological media. Although metabolomics, alone or combined with other omics data, has already demonstrated its relevance for patient stratification frame research projects clinical studies, much remains be done move this approach practice. This is especially true perspective being applied personalized/precision medicine, which aims at stratifying patients according their risk developing diseases, tailoring medical treatments individual characteristics order improve efficacy limit toxicity. In review article, we discuss main challenges linked analytical chemistry that need addressed foster implementation metabolomics clinics use data produced by personalized medicine. First all, there are well-known issues related untargeted workflows levels production (lack standardization), metabolite identification (small proportion annotated features identified metabolites), processing (from automatic detection multi-omic integration) hamper inter-operability reusability data. Furthermore, outputs complex molecular signatures few tens metabolites, often abundance variations, obtained expensive laboratory equipment. It thus necessary simplify these so they can used field. last point, still poorly community, may crucial a near future increased availability societal demand participatory Graphical abstract

Язык: Английский

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