Targeting Agrobacterium tumefaciens: A Computational Study on Quorum Sensing Inhibition DOI Creative Commons
Jayanthi Barasarathi, Kahkashan Perveen,

Faheema Khan

и другие.

Journal of Basic Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

ABSTRACT Crown gall disease, caused by Agrobacterium tumefaciens , results in significant loss agricultural productivity losses due to induced tumor‐like growths on various crops. The virulence of A. is controlled its quorum sensing (QS) system, specifically through the TraR protein, which regulates expression genes essential for pathogenicity and plasmid transfer. Beyond pathogenic interactions, QS plays a crucial role plant microbiome, influencing symbiosis, competition, health. This study aimed identify inhibitors (QSIs) that disrupt TraR‐mediated signaling as novel approach mitigate crown disease while exploring broader implications plant‐microbe interactions. Using combination molecular docking, dynamics (MD) simulations, protein−protein interaction analysis, we screened library potential QSIs identified N‐phenylselenourea potent candidate with binding affinity −8 kcal/mol TraR. MD simulations confirmed stability this compound within pocket, strong interactions observed key residues such Tyr53 Asp70. Gene Ontology (GO) enrichment analysis supported these findings, highlighting disruption critical pathways. Our findings underscore dual benefits QSIs, offering targeted strategy control infections potentially enhancing plant‐microbiome improved lays groundwork developing sustainable practices leveraging manage diseases promote beneficial microbial communities.

Язык: Английский

Unveiling the significance of rhizosphere: Implications for plant growth, stress response, and sustainable agriculture DOI Creative Commons

Wogene Solomon,

Tibor Janda, Zoltán Molnár

и другие.

Plant Physiology and Biochemistry, Год журнала: 2023, Номер 206, С. 108290 - 108290

Опубликована: Дек. 22, 2023

In the rhizosphere, activities within all processes and functions are primarily influenced by plant roots, microorganisms present in interactions between roots microorganisms. The a dynamic zone surrounding provides an ideal environment for diverse microbial community, which significantly shapes growth development. Microbial activity rhizosphere can promote increasing nutrient availability, influencing hormonal signaling, repelling or outcompeting pathogenic strains. Understanding associations soil has potential to revolutionize crop yields, improve productivity, minimize reliance on chemical fertilizers, sustainable technologies. microbiome could play vital role next green revolution contribute eco-friendly agriculture. However, there still knowledge gaps concerning root-environment interactions, particularly regarding Advances metabolomics have helped understand communication plants biota, yet challenges persist. This article overview of latest advancements comprehending interplay microbes, been shown impact crucial factors such as growth, gene expression, absorption, pest disease resistance, alleviation abiotic stress. By improving these aspects, agriculture practices be implemented increase overall productivity ecosystems.

Язык: Английский

Процитировано

65
Anti-biofilm activity of marine algae-derived bioactive compounds DOI Creative Commons
Asma Behzadnia, Marzieh Moosavi‐Nasab, Najmeh Oliyaei

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Апрель 12, 2024

A large number of microbial species tend to communicate and produce biofilm which causes numerous infections, antibiotic resistance, economic problems across different industries. Therefore, advanced anti-biofilms are required with novel attributes targets, such as quorum sensing communication system. Meanwhile, inhibitors promising anti-biofilm molecules result in the inhibition particular phenotype expression blocking cell-to-cell communication, would be more acceptable than conventional strategies. Many natural products identified agents from plants, microorganisms, marine extracts. Marine algae sources broadly compounds activity. Algae extracts their metabolites sulfated polysaccharides (fucoidan), carotenoids (zeaxanthin lutein), lipid fatty acids (γ-linolenic acid linoleic acid), phlorotannins can inhibit cell attachment, reduce growth, interfere pathway by related enzymes, disrupt extracellular polymeric substances. In this review, mechanisms formation, pathway, recently will discussed.

Язык: Английский

Процитировано

16
Omics approaches in understanding the benefits of plant-microbe interactions DOI Creative Commons
Archana Jain, Surendra Sarsaiya,

Ranjan Singh

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Май 27, 2024

Plant-microbe interactions are pivotal for ecosystem dynamics and sustainable agriculture, influenced by various factors, such as host characteristics, environmental conditions, human activities. Omics technologies, including genomics, transcriptomics, proteomics, metabolomics, have revolutionized our understanding of these interactions. Genomics elucidates key genes, transcriptomics reveals gene expression dynamics, proteomics identifies essential proteins, metabolomics profiles small molecules, thereby offering a holistic perspective. This review synthesizes diverse microbial-plant interactions, showcasing the application omics in mechanisms, nitrogen fixation, systemic resistance induction, mycorrhizal association, pathogen-host Despite challenges data integration ethical considerations, approaches promise advancements precision intervention resilient agricultural practices. Future research should address challenges, enhance technology resolution, explore epigenomics, understand plant-microbe under conditions. In conclusion, technologies hold immense optimizing strategies fortifying alliances, paving way agriculture stewardship.

Язык: Английский

Процитировано

16
Microbiome Engineering for Sustainable Rice Production: Strategies for Biofertilization, Stress Tolerance, and Climate Resilience DOI Creative Commons

Israt Jahan Misu,

Md. Omar Kayess, Md. Nurealam Siddiqui

и другие.

Microorganisms, Год журнала: 2025, Номер 13(2), С. 233 - 233

Опубликована: Янв. 22, 2025

The plant microbiome, found in the rhizosphere, phyllosphere, and endosphere, is essential for nutrient acquisition, stress tolerance, overall health of plants. This review aims to update our knowledge critically discuss diversity functional roles rice as well microbiome engineering strategies enhance biofertilization resilience. Rice hosts various microorganisms that affect cycling, growth promotion, resistance stresses. Microorganisms carry out these functions through nitrogen fixation, phytohormone metabolite production, enhanced solubilization uptake, regulation host gene expression. Recent research on molecular biology has elucidated complex interactions within microbiomes signalling mechanisms establish beneficial microbial communities, which are crucial sustainable production environmental health. Crucial factors successful commercialization agents include soil properties, practical field conditions, genotype. Advances engineering, from traditional inoculants synthetic biology, optimize availability resilience abiotic stresses like drought. Climate change intensifies challenges, but innovations microbiome-shaping genes (M genes) offer promising solutions crop also discusses agronomic implications emphasizing need further exploration M breeding disease traits. Ultimately, we provide an current findings rice, highlighting pathways productivity sustainably while minimizing impacts.

Язык: Английский

Процитировано

2
Quorum Sensing of Bifidobacteria: Research and Progress DOI
Huahui Li, Bin He,

Ning Ma

и другие.

Microbiological Research, Год журнала: 2025, Номер 294, С. 128102 - 128102

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

2
The intricate symbiotic relationship between lactic acid bacterial starters in the milk fermentation ecosystem DOI Creative Commons
Shujuan Yang, Mei Bai, Lai‐Yu Kwok

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 65(4), С. 728 - 745

Опубликована: Ноя. 20, 2023

Fermentation is one of the most effective methods food preservation. Since ancient times, has been fermented using lactic acid bacteria (LAB). Fermented milk a very intricate fermentation ecosystem, and microbial metabolism largely determines its metabolic properties. The two frequently used dairy starter strains are

Язык: Английский

Процитировано

26
The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review DOI Creative Commons
Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa

и другие.

Journal of Chemistry, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

The formation of biofilms occurs due to a group bacteria gathering together. increasing cell density will stimulate chemical signals for communicate through quorum sensing system. Quorum plays role competition, virulence, resistance, and pathogenesis. produces signaling response called as autoinducers. Gram‐negative produce N ‐acyl‐ L ‐homoserine lactones autoinducer, while in Gram‐positive autoinducing peptides. By looking at responses bacterial pathogenesis the study natural antibiotic agents became particular concern researchers. This review summarizes systems acting on bacteria, biofilm by pathogenic potential use medicinal plants anti–quorum reviewed vitro silico. extracts from leaves, fruits, flowers, stems, isolated compounds some types essential oils has been successfully tested have activity.

Язык: Английский

Процитировано

1
Bioorganic compounds in quorum sensing disruption: strategies, Mechanisms, and future prospects DOI
Tarunkarthick Subramani, Harish Saravanan, Helma David

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108192 - 108192

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Plant Colonization by Biocontrol Bacteria and Improved Plant Health: A Review DOI Creative Commons
Roohallah Saberi Riseh, Fariba Fathi, Mozhgan Gholizadeh Vazvani

и другие.

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 14, 2025

The use of biological control agents is one the best strategies available to combat plant diseases in an ecofriendly manner. Biocontrol bacteria capable providing beneficial effect crop growth and health, have been developed for several decades. It highlights need a deeper understanding colonization mechanisms employed by biocontrol enhance their efficacy pathogen control. present review deals with in-depth steps involved host bacteria. process starts from root zone, where establish initial interactions plant’s system. Moving beyond roots, migrate colonize other organs, including stems, leaves, even flowers. Also, attempts explore facilitating bacterial movement within such as migrating through interconnected spaces vessels or apoplast, applying quorum sensing extracellular enzymes during what needed long-term association plant. impacts on microbial community dynamics, nutrient cycling, overall health are discussed, emphasizing intricate relationships between microbiome benefits above-ground parts, 40 confer. By unraveling these mechanisms, researchers can develop targeted enhancing efficiency effectiveness bacteria, leading more sustainability resilience.

Язык: Английский

Процитировано

1
Metagenomics-based study of rhizospheric microorganisms of Poa alpigena L. in Qinghai Lake, Ganzi River Plateau DOI Creative Commons
Bo Wei, Qianqian Xu,

Junfei Kong

и другие.

Frontiers in Plant Science, Год журнала: 2025, Номер 15

Опубликована: Фев. 21, 2025

Poa alpigena Lindm., a dominant forage grass on the Tibetan Plateau, plays critical role in livestock production and grassland restoration. This study investigates rhizospheric non-rhizospheric soil microorganisms of L. Ganzi River area Qinghai Lake basin using metagenomic sequencing to understand their diversity potential ecological functions. Soil samples were collected from areas S-type five-point sampling method. DNA was extracted, performed BGISEQ-500 platform. Alpha Beta analyses conducted, LEfSe analysis used identify differentially abundant microbial taxa metabolic pathways. A total 5,681 species across 1,606 genera, 521 families, 61 phyla, 246 orders identified. Non-rhizospheric soils exhibited higher richness than soils. Proteobacteria most phylum both types. Rhizospheric showed significant enrichment pathways related antibiotic biosynthesis, carbon metabolism, methane while enriched quorum sensing drug-metabolizing The findings highlight selective influence communities mitigating emissions. provides foundation for understanding functions alpine meadows supports sustainable management practices.

Язык: Английский

Процитировано

1