Fabrication and Evaluation of Dissolving Hyaluronic Acid Microneedle Patches for Minimally Invasive Transdermal Drug Delivery by Nanoimprinting
Gels,
Год журнала:
2025,
Номер
11(2), С. 89 - 89
Опубликована: Янв. 23, 2025
Transdermal
drug
delivery
minimizes
pain
and
provides
a
controlled,
stable
release
of
drugs,
but
its
effectiveness
is
limited
by
the
skin’s
natural
barriers.
Microneedles
overcome
this
problem,
enabling
minimally
invasive
delivery.
Microneedle
patches
(MNPs)
with
80
µm-tall
needles
composed
hyaluronic
acid
(HA)
were
developed
evaluated
for
their
formability,
structural
integrity,
dissolution
rate,
skin
penetration
ability,
transmission
capacity.
The
influence
molecular
weight
HA
on
these
properties
was
also
investigated.
MNPs
made
from
low-molecular-weight
(30
kDa–50
kDa)
demonstrated
12.5
times
superior
permeability
in
ex
vivo
human
compared
to
needleless
(NLPs).
Furthermore,
same
test,
had
1.7
higher
than
high-molecular-weight
MNPs,
suggesting
transdermal
administration.
significantly
influenced
solubility
permeability,
highlighting
potential
as
systems.
Puncture
tests
depth
50–60
µm,
indicating
minimal
nerve
irritation
dermis
effective
superficial
dermal
layer.
These
results
present
manufacturing
technique
incorporating
model
compounds
highlight
novel
method
biomedical
applications
soft
gels.
Язык: Английский
Advancements in Micro/Nanorobots in Medicine: Design, Actuation, and Transformative Application
ACS Omega,
Год журнала:
2025,
Номер
10(6), С. 5214 - 5250
Опубликована: Фев. 4, 2025
In
light
of
the
ongoing
technological
transformation,
embracing
advancements
that
foster
shared
benefits
is
essential.
Nanorobots,
a
breakthrough
within
nanotechnology,
have
demonstrated
significant
potential
in
fields
such
as
medicine,
where
diagnostic
and
therapeutic
applications
are
primary
focus
areas.
This
review
provides
comprehensive
overview
robots,
their
evolving
role
medical
applications,
particularly
highlighting
use
nanorobots.
Various
design
strategies
operational
principles,
including
sensors,
actuators,
nanocontrollers,
discussed
based
on
prior
research.
Key
nanorobot
include
biomedical
imaging,
biosensing,
minimally
invasive
surgery,
targeted
drug
delivery,
each
utilizing
advanced
actuation
technologies
to
enhance
precision.
The
paper
further
examines
recent
progress
micro/nanorobot
addresses
important
considerations
for
future,
biocompatibility,
control,
navigation,
targeting,
safety,
ethical
implications.
offers
holistic
perspective
how
nanorobots
can
reshape
practices,
paving
way
precision
medicine
improved
patient
outcomes.
Язык: Английский
Microfluidic Impedance Sensing Distinguishes Cancer Cell States: A Step Towards point-of-care diagnostics
Biosensors and Bioelectronics X,
Год журнала:
2025,
Номер
unknown, С. 100589 - 100589
Опубликована: Фев. 1, 2025
Язык: Английский
Suppressing parasitic flow in membraneless diffusion-based microfluidic gradient generators
Lab on a Chip,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Diffusion-based
microfluidic
gradient
generators
(DMGGs)
are
essential
for
various
in
vitro
studies
due
to
their
ability
provide
a
convection-free
concentration
gradient.
However,
these
systems,
often
referred
as
membrane-based
DMGGs,
exhibit
delayed
formation
the
incorporated
flow-resistant
membrane.
This
limitation
substantially
hinders
application
dynamic
and
time-sensitive
studies.
Here,
we
accelerate
response
DMGGs
by
removing
membrane
implementing
new
geometrical
configurations
compensate
membrane's
role
suppressing
parasitic
flows.
We
introduce
novel
into
two
designs:
H-junction
Y-junction.
In
design,
flow
is
redirected
through
bypass
channel
following
region.
The
Y-junction
design
features
shared
discharge
that
allows
converging
streams,
preventing
buildup
of
pressure
downstream
Using
hydraulic
circuit
analysis
fluid
dynamics
simulations,
demonstrate
effectiveness
designs
These
computational
results,
supported
experimental
data
from
particle
image
velocimetry,
confirm
capability
our
generate
highly
stable,
accurate,
with
rapid
formation.
advantages
make
ideal
platforms
wide
range
studies,
including
drug
testing,
cell
chemotaxis,
stem
differentiation.
Язык: Английский
Innovative Micro- and Nano-Architectures in Biomedical Engineering for Therapeutic and Diagnostic Applications
Micromachines,
Год журнала:
2025,
Номер
16(4), С. 419 - 419
Опубликована: Март 31, 2025
The
rapid
evolution
of
micro-
and
nano-architectures
is
revolutionizing
biomedical
engineering,
particularly
in
the
fields
therapeutic
diagnostic
micromechanics.
This
review
explores
recent
innovations
nanostructured
materials
their
transformative
impact
on
healthcare
applications,
ranging
from
drug
delivery
tissue
engineering
to
biosensing
diagnostics.
Key
advances
fabrication
techniques,
such
as
lithography,
3D
printing,
self-assembly,
have
enabled
unprecedented
control
over
material
properties
functionalities
at
microscopic
scales.
These
engineered
architectures
offer
enhanced
precision
targeting
controlled
release
delivery,
foster
cellular
interactions
improve
sensitivity
specificity
devices.
We
examine
critical
design
parameters,
including
biocompatibility,
mechanical
resilience,
scalability,
which
influence
clinical
efficacy
long-term
stability.
also
highlights
translational
potential
current
limitations
bringing
these
laboratory
research
practical
applications.
By
providing
a
comprehensive
overview
trends,
challenges,
future
perspectives,
this
article
aims
inform
inspire
further
development
that
hold
promise
for
advancing
personalized
medicine.
Язык: Английский
Enhancing glaucoma care with smart contact lenses: An overview of recent developments
Biomedical Microdevices,
Год журнала:
2025,
Номер
27(2)
Опубликована: Апрель 21, 2025
Abstract
Glaucoma
is
a
leading
cause
of
irreversible
blindness
worldwide,
affecting
millions
individuals
due
to
its
progressive
damage
the
optic
nerve,
often
caused
by
elevated
intraocular
pressure
(IOP).
Conventional
methods
IOP
monitoring,
such
as
tonometry,
provide
sporadic
and
inaccurate
readings
fluctuations
throughout
day,
leaving
significant
gaps
in
diagnosis
treatment.
This
review
explores
transformative
potential
smart
contact
lenses
equipped
with
continuous
monitoring
therapeutic
capabilities.
These
integrate
advanced
materials
graphene,
nanogels,
magnetic
oxide
nanosheets
alongside
sophisticated
biosensing
wireless
communication
systems.
By
offering
continuous,
real-time
data,
these
can
detect
subtle
immediate
feedback
patients
clinicians.
Moreover,
drug-eluting
capabilities
embedded
present
groundbreaking
approach
glaucoma
therapy
improving
medication
adherence
providing
controlled
drug
release
directly
eye.
Beyond
management,
innovations
also
pave
way
for
biochemical
markers
other
ocular
diseases.
Challenges
biocompatibility,
long-term
wearability,
affordability
remain,
but
integration
cutting-edge
technologies
signifies
paradigm
shift
care.
developments
hold
immense
promise
advancing
personalized
medicine,
patient
outcomes,
mitigating
global
burden
blindness.
Язык: Английский
Applications of microfluidics in mRNA vaccine development: A review
Biomicrofluidics,
Год журнала:
2024,
Номер
18(6)
Опубликована: Ноя. 14, 2024
The
transformative
potential
of
microfluidics
in
the
development
mRNA
vaccines
is
explored
this
review,
highlighting
its
pivotal
role
enhancing
easy-to-use
functionality,
efficacy,
and
production
efficiency.
Moreover,
we
examine
innovative
applications
biomedical
research,
including
contribution
to
rapid
cost-effective
synthesis
lipid
nanoparticles
for
delivery
delve
into
advantages
vaccines,
such
as
targeted
controlled
expression.
Furthermore,
it
outlines
future
prospects
microfluidic
devices,
their
cutting-edge
examples
both
research
industry,
revolutionize
vaccine
formulation
production.
integration
with
represents
a
significant
advancement
public
health
disease
prevention
strategies.
Язык: Английский