Plants,
Год журнала:
2022,
Номер
12(1), С. 38 - 38
Опубликована: Дек. 21, 2022
Recombinant
proteins
are
the
most
important
product
of
current
industrial
biotechnology.
They
indispensable
in
medicine
(for
diagnostics
and
treatment),
food
chemical
industries,
research.
Plant
cells
combine
advantages
eukaryotic
protein
production
system
with
simplicity
efficacy
bacterial
one.
The
use
plants
for
recombinant
is
an
economically
promising
area
that
has
emerged
as
alternative
to
traditional
approaches.
This
review
discusses
plant
systems
expression
using
nuclear,
plastid,
mitochondrial
genomes.
Possibilities,
problems,
prospects
modifications
three
parts
genome
light
obtaining
producer
examined.
Examples
successful
nuclear
platform
various
biopharmaceuticals,
veterinary
drugs,
technologically
described,
examples
a
high
yield
upon
modification
chloroplast
genome.
Potential
utility
mitochondria
its
over
nucleus
chloroplasts
substantiated.
Although
these
opportunities
have
not
yet
been
exploited,
potential
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1185 - 1185
Опубликована: Янв. 25, 2023
Chlamydomonas
reinhardtii
(C.
reinhardtii)
is
one
of
the
most
well-studied
microalgae
organisms
that
revealed
important
information
for
photosynthetic
and
metabolic
processes
plants
eukaryotes.
Numerous
extensive
studies
have
also
underpinned
its
great
potential
as
a
biochemical
factory,
capable
producing
various
highly
desired
molecules
with
direct
impact
on
human
health
longevity.
Polysaccharides,
lipids,
functional
proteins,
pigments,
hormones,
vaccines,
antibodies
are
among
valuable
biomolecules
produced
spontaneously
or
under
well-defined
conditions
by
C.
can
be
directly
linked
to
nutrition
diet.
The
aim
this
review
highlight
recent
advances
in
field
focusing
relevant
applications
related
production
limitations
challenges
critically
discussed
along
future
biomass
processed
products
nutraceuticals
food
supplements.
increasing
need
high-value
low-cost
an
environmentally
economy
sustainable
manner
underline
role
reinhardtii.
Journal of Applied Phycology,
Год журнала:
2023,
Номер
35(4), С. 1635 - 1648
Опубликована: Июнь 24, 2023
Abstract
Microalgae
are
considered
the
most
promising
source
of
renewable
fuels,
high-value
bio-products
and
nutraceuticals.
Potentially,
microalgae
can
satisfy
many
global
demands,
but
in
large-scale
cultivation
average
productivity
industrial
strains
is
lower
than
maximal
theoretical
estimations,
mainly
due
to
sub-optimal
growth
conditions.
Although
have
developed
complex
strategies
cope
with
environmental
stresses,
outdoor
photobioreactors
limited
few
species
it
not
yet
sufficiently
remunerative.
Indeed,
microalgal
very
sensitive
conditions,
changes
solar
irradiation,
temperature,
medium
composition
drastically
decrease
biomass
yield.
Developing
new
for
improving
algal
tolerance
stress
conditions
thus
greatly
desirable.
One
first
responses
that
occur
both
higher
plants
microorganisms
following
exposure
abiotic
an
increased
synthesis
accumulation
amino
acid
proline.
While
role
proline
adaptation
well-recognized
plants,
implication
still
awaits
full
elucidation.
In
this
review
we
summarize
available
data
on
metabolism
under
eukaryotic
microalgae.
Possible
implications
toward
optimization
biotechnological
purposes
also
discussed.
Microbial Biotechnology,
Год журнала:
2024,
Номер
17(6)
Опубликована: Июнь 1, 2024
Pharmaceuticals
are
of
increasing
environmental
concern
as
they
emerge
and
accumulate
in
surface-
groundwater
systems
around
the
world,
endangering
overall
health
aquatic
ecosystems.
Municipal
wastewater
discharge
is
a
significant
vector
for
pharmaceuticals
their
metabolites
to
enter
surface
waters
humans
incompletely
absorb
prescription
drugs
excrete
up
50%
into
wastewater,
which
subsequently
removed
during
treatment.
Microalgae
present
promising
target
improving
treatment
due
ability
remove
some
pollutants
efficiently.
However,
inherent
metabolic
pathways
limit
capacity
degrade
more
recalcitrant
organic
compounds
such
pharmaceuticals.
The
human
liver
employs
enzymes
break
down
drugs,
these
extensively
researched
drug
development,
meaning
cytochrome
P450
responsible
metabolizing
each
approved
well
studied.
Thus,
unlocking
or
expression
endogenous
microalgae
could
be
cost-effective
strategy
reduce
pharmaceutical
loads
effluents.
Here,
we
discuss
challenges
opportunities
associated
with
introducing
microalgae.
We
anticipate
that
P450-engineered
can
serve
new
removal
method
sustainable
solution
upgrade
facilities
function
"mega
livers".
Marine Drugs,
Год журнала:
2024,
Номер
22(7), С. 304 - 304
Опубликована: Июнь 28, 2024
From
sea
shores
to
the
abysses
of
deep
ocean,
marine
ecosystems
have
provided
humanity
with
valuable
medicinal
resources.
The
use
organisms
is
discussed
in
ancient
pharmacopoeias
different
times
and
geographic
regions
still
deeply
rooted
traditional
medicine.
Thanks
present-day,
large-scale
bioprospecting
rigorous
screening
for
bioactive
metabolites,
ocean
coming
back
as
an
untapped
resource
natural
compounds
therapeutic
potential.
This
renewed
interest
drugs
propelled
by
a
burgeoning
research
field
investigating
molecular
mechanisms
which
newly
identified
intervene
pathophysiology
human
diseases.
Of
great
clinical
relevance
are
molecules
endowed
anti-inflammatory
immunomodulatory
properties
emerging
applications
management
chronic
inflammatory
disorders,
autoimmune
diseases,
cancer.
Here,
we
review
historical
development
pharmacology
Eastern
Western
worlds
describe
status
drug
discovery.
Finally,
discuss
importance
conducting
sustainable
exploitation
resources
through
biotechnology.
Marine Drugs,
Год журнала:
2025,
Номер
23(2), С. 86 - 86
Опубликована: Фев. 17, 2025
Marine
phytoplankton
is
an
emerging
source
of
immunomodulatory
bioactive
lipids
(BLs).
Under
physiological
growth
conditions
and
upon
stress
challenges,
several
eukaryotic
microalgal
species
accumulate
lipid
metabolites
that
resemble
the
precursors
animal
mediators
inflammation:
eicosanoids
prostaglandins.
Therefore,
marine
could
serve
as
a
biotechnological
platform
to
produce
functional
BLs
with
therapeutic
applications
in
management
chronic
inflammatory
diseases
other
clinical
conditions.
However,
be
commercially
competitive,
lipidic
precursor
yields
should
enhanced.
Beside
tailoring
cultivation
native
producers,
genetic
engineering
feasible
strategy
accrue
production
introduce
heterologous
biosynthetic
pathways
hosts.
Here,
we
present
state-of-the-art
research
on
from
discuss
synthetic
biology
approaches
boost
their
light-driven
biosynthesis.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3890 - 3890
Опубликована: Апрель 20, 2025
Microalgae
represent
a
promising
platform
for
the
synthesis
of
recombinant
proteins,
particularly
in
context
biopharmaceutical
applications.
Their
unique
combination
eukaryotic
cellular
machinery
and
prokaryotic-like
simplicity
offers
several
advantages,
including
ability
to
perform
complex
post-translational
modifications,
rapid
growth
rates,
cost-effective
culture
conditions.
Advances
genome
sequencing,
genetic
engineering
tools,
omics
technologies
have
significantly
enhanced
feasibility
efficiency
using
microalgae
therapeutic
protein
production.
These
advancements,
coupled
with
development
well-established
transformation
methods
optimized
vectors,
enabled
successful
expression
various
biopharmaceuticals,
ranging
from
vaccines
enzymes.
Here,
main
stages
current
status
production
exogenic
proteins
dedicated
human
therapy
are
presented.
