Frontiers in Psychiatry,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 9, 2024
Autism
spectrum
disorder
(ASD)
is
a
multifaceted
developmental
condition
that
commonly
appears
during
early
childhood.
The
etiology
of
ASD
remains
multifactorial
and
not
yet
fully
understood.
identification
biomarkers
may
provide
insights
into
the
underlying
mechanisms
pathophysiology
disorder.
present
study
aimed
to
explore
causes
by
investigating
key
biomedical
markers,
trace
elements,
microbiota
factors
between
children
with
autism
control
subjects.
Microorganisms,
Год журнала:
2022,
Номер
10(12), С. 2436 - 2436
Опубликована: Дек. 9, 2022
The
role
of
the
gut
microbiome
in
mental
health
has
been
great
interest
past
years,
with
several
breakthroughs
happening
last
decade.
Its
implications
psychiatric
disorders,
namely
anxiety,
depression,
autism
and
schizophrenia,
are
highlighted.
In
this
review
were
included
relevant
studies
on
rodents,
as
well
human
studies.
There
seems
to
be
a
connection
between
these
pathologies,
link
being
emphasized
both
rodents
humans.
results
obtained
murine
models
align
acquired
from
patients;
however,
fewer
regarding
anxiety
conducted
process
sequencing
analyzing
humans
for
other
pathologies
mentioned
above.
Additionally,
possible
beneficial
probiotics
postbiotics
administered
an
aid
medication
was
analyzed.
Brain Sciences,
Год журнала:
2024,
Номер
14(2), С. 120 - 120
Опубликована: Янв. 24, 2024
Rett
syndrome
(RTT)
is
a
neurological
disorder
that
mostly
affects
females,
with
frequency
of
1
in
10,000
to
20,000
live
birth
cases.
Symptoms
include
stereotyped
hand
movements;
impaired
learning,
language,
and
communication
skills;
sudden
loss
speech;
reduced
lifespan;
retarded
growth;
disturbance
sleep
breathing;
seizures;
autism;
gait
apraxia.
Pneumonia
the
most
common
cause
death
for
patients
syndrome,
survival
rate
77.8%
at
25
years
age.
Survival
into
fifth
decade
typical
leading
cardiorespiratory
compromise.
progression
has
multiple
stages;
however,
phenotypes
are
associated
nervous
system
brain.
In
total,
95%
cases
due
mutations
MECP2
gene,
an
X-linked
gene
encodes
methyl
CpG
binding
protein,
regulator
expression.
this
review,
we
summarize
recent
developments
field
therapeutics
targeting
MECP2.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 20, 2025
Autism
spectrum
disorder
(ASD)
is
a
neurodevelopmental
characterized
by
social
communication
and
interaction
problems.
The
prevalence
of
ASD
increasing
globally,
with
higher
ratio
males
to
females.
Gastrointestinal
symptoms
are
common
in
individuals
ASD,
gut
microbiota
has
been
implicated
the
disorder's
development.
This
study
aimed
investigate
alteration
Thai
compared
healthy
controls
using
16S
rRNA
gene
sequencing.
influence
gender
age
on
composition
function
was
also
examined.
A
total
65
30
neurotypical
(NT)
were
included
analysis.
results
revealed
notable
differences
between
NT
groups,
variations
observed
microbial
richness
presence
enriched
taxa.
These
influenced
both
age.
Fusobacteriota,
Fusobacteriaceae,
Fusobacterium
found
be
ASD.
Furthermore,
identified
gender-related
taxa,
such
as
Bacteroides
plebeius,
Age-related
including
Veillonella,
known
associated
poor
oral
hygiene,
children.
analysis
differentially
abundant
pathways
highlighted
enrichment
various
metabolic
those
related
endocrine-disrupting
chemicals.
findings
underscore
importance
considering
when
studying
They
provide
valuable
insights
into
potential
role
dysbiosis
pathogenesis
highlight
environmental
factors.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 9, 2025
Emerging
evidence
has
highlighted
that
altered
gut
microbiota
are
associated
with
the
onset
and
progression
of
depression
via
regulating
gut-brain
axis.
However,
existing
research
predominantly
focused
on
children
adults,
frequently
neglecting
adolescent
depression.
Given
rising
prevalence
substantial
impact
functional
impairment
suicidality,
it
is
essential
to
focus
more
this
age
group.
In
study,
we
examined
fecal
inflammatory
profiles
99
depressed
adolescents
106
age-matched
healthy
controls
using
Illumina
NovaSeq
sequencing
multiplex
immunoassays,
respectively.
Our
findings
revealed
lower
bacterial
α-diversity
richness,
alongside
β-diversity
in
Gut
dysbiosis
was
characterized
by
increased
pro-inflammatory
genera
such
as
Streptococcus
decreased
anti-inflammatory
like
Faecalibacterium.
These
differential
may
serve
potential
non-invasive
biomarkers
for
depression,
either
individually
or
combination.
We
also
observed
disruptions
inferred
functions
depression-associated
microbiota,
particularly
glycolysis
gluconeogenesis.
Additionally,
exhibited
systemic
immune
dysfunction,
elevated
levels
cytokines
chemokines,
which
showed
significant
correlations
genera.
study
bridges
gap
between
adults
providing
new
insights
into
characteristics
their
links
system
adolescents,
offer
targets
diagnosis
treatment
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Авг. 27, 2024
Introduction
The
pathogenesis
of
Attention-Deficit
Hyperactivity
Disorder
(ADHD)
is
thought
to
be
multifactorial,
with
a
potential
role
for
the
bidirectional
communication
between
gut
microbiome
and
brain
development
function.
Since
“golden-standard”
medication
therapy
methylphenidate
(MPH)
linked
multiple
adverse
effects,
there
need
alternative
treatment
options
such
as
dietary
polyphenols.
These
secondary
plant
metabolites
exert
antioxidant
anti-inflammatory
but
much
less
known
about
their
impact
on
microbiota.
polyphenols
are
believed
modulate
microbial
composition,
interventions
might
advantageous
in
ADHD
therapy.
Therefore,
intervention
studies
investigating
composition
highly
relevant.
Methods
Besides
primary
research
questions
addressed
previously,
this
study
explored
prebiotic
effect
polyphenol-rich
French
Maritime
Pine
Bark
Extract
(PBE)
compared
MPH
placebo
pediatric
patients
by
studying
microbiota
via
amplicon
sequencing
full
length
16S
rRNA
gene
ribosomal
subunit
(V1-V9).
Results
One
interesting
finding
was
high
relative
abundance
Bifidobacteria
among
all
our
cohort.
Moreover,
has
identified
that
(placebo,
PBE)
explains
3.94%
variation
distribution
taxa
(adjusted
p
-value
0.011).
Discussion
Our
small
sample
size
(placebo:
n
=
10;
PBE:
13
MPH:
14)
did
not
allow
observe
clear
effects
treated
PBE.
Notwithstanding
limitation,
subtle
changes
were
noticeable
some
limited
compositional
could
observed.
Clinical
Trial
Registration
doi:
10.1186/S13063-017-1879-6
