BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis

Brain Research Bulletin, Год журнала: 2024, Номер 207, С. 110882 - 110882

Опубликована: Янв. 19, 2024

Emerging evidence supports the gut microbiota and brain communication in general health. This axis may affect behavior through modulating neurotransmission, thereby involve pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor cAMP response element-binding protein known CREB/BDNF pathway plays have critical functions depression same mechanisms related to antidepressants. However, putative causal significance signaling cascade gut-brain remains unknown. Also interventions probiotics supplementation exercise can influence microbiome also improve bidirectional brain. In this review we aim explain BDNF/CREB dysfunction then evaluate potential role probiotics, prebiotics, a therapeutic target induced The current narrative will specifically focus on impact diet intestinal component, well effect that these therapies alleviate depressive symptoms. Finally, look at how exert distinct effects dysfunction.

Язык: Английский

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Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis

Nutrients, Год журнала: 2024, Номер 16(7), С. 1070 - 1070

Опубликована: Апрель 5, 2024

Background: The equilibrium between gut microbiota (GM) and the host plays a pivotal role in maintaining overall health, influencing various physiological metabolic functions. Emerging research suggests that exercise modulates abundance functionality of bacteria, yet comprehensive effects on GM diversity remain to be synthesized. Objectives Design: study aims quantitatively examine effect adults using systemic review meta-analysis approach. Methods: PubMed, Ebsco, Embase, Web Science, Cochrane Central Register Controlled Trials, China National Knowledge Infrastructure, Wanfang Data were searched from their inception September 2023. Exercise intervention studies with control group describe compare composition adults, 16S rRNA gene sequencing, included this meta-analysis. Results: A total 25 1044 participants. Based fixed-effects model [Chi2 = 29.40, df 20 (p 0.08); I2 32%], pooled analysis showed compared group, can significantly increase alpha adult GM, Shannon index as an example [WMD 0.05, 95% CI (0.00, 0.09); Z 1.99 0.05)]. In addition, interventions found alter notably decreasing Bacteroidetes increasing Firmicutes, indicating shift Firmicutes/Bacteroidetes ratio. subgroup indicates females older appear exhibit more significant changes Index observed OTUs. Conclusions: may promising way improve adults. particular, was increased after exercise. Distinct responses based gender age implicated needed.

Язык: Английский

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Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102664 - 102664

Опубликована: Янв. 1, 2025

Язык: Английский

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Omega-3 Polyunsaturated Fatty Acids: A Clinical Perspective on Gut Microbiota, Major Depressive Disorder, and Obesity

Psychiatric Annals, Год журнала: 2025, Номер 55(2)

Опубликована: Фев. 1, 2025

Major depressive disorder (MDD) and obesity are significant global health concerns with a strong bidirectional relationship. Gut microbiota dysbiosis has been implicated in both MDD obesity, characterized by alterations microbial diversity its metabolites. Omega-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA), docosahexaenoic (DHA) have shown promise alleviating symptoms improving metabolic health. Diet plays crucial role shaping gut microbiota, omega-3 PUFAs emerging as potential therapeutic target. By modulating reducing inflammation, influencing neurotransmitter systems, may offer novel approach to treating obesity. This article will investigate the of relationship between depression via microbiome inflammation. Further investigation is needed establish optimal dosage supplementation for individuals comorbid [ Psychiatr Ann . 2025;55(2):e34–e39.]

Язык: Английский

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Microbiota–gut–brain axis: the mediator of exercise and brain health

Deleted Journal, Год журнала: 2024, Номер 4

Опубликована: Янв. 1, 2024

Abstract The brain controls the nerve system, allowing complex emotional and cognitive activities. microbiota–gut–brain axis is a bidirectional neural, hormonal, immune signaling pathway that could link gastrointestinal tract to brain. Over past few decades, gut microbiota has been demonstrated be an essential component of plays crucial role in regulating most functions various body organs. effects on occur through production neurotransmitters, hormones, metabolites, regulation host-produced or synthesis metabolites by themselves. This affects host's behavior, mood, attention state, brain's food reward system. Meanwhile, there intimate association between exercise. Exercise can change numerically qualitatively, which may partially responsible for widespread benefits regular physical activity human health. Functional magnetic resonance imaging (fMRI) non-invasive method show areas enabling delineation specific regions involved neurocognitive disorders. Through combining exercise tasks fMRI techniques, researchers observe higher functions. However, exercise's health via have little studied. article reviews highlights connections these three interactions, will help us further understand positive provide new strategies approaches prevention treatment diseases.

Язык: Английский

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Unveiling the potential of estrogen: Exploring its role in neuropsychiatric disorders and exercise intervention

Pharmacological Research, Год журнала: 2024, Номер 204, С. 107201 - 107201

Опубликована: Май 3, 2024

Neuropsychiatric disorders shorten human life spans through multiple ways and become major threats to health. Exercise can regulate the estrogen signaling, which may be involved in depression, Alzheimer's disease (AD) Parkinson's (PD), other neuropsychiatric as well their sex differences. In nervous system, is an important regulator of cell development, synaptic brain connectivity. Therefore, this review aimed investigate potential system exercise intervention better understand its specific. exert a protective effect regulating expression receptors, are neuroprotection, neurodevelopment, neuronal glucose homeostasis. These processes mediated by downstream factors including N-myc regulatory gene 2 (Ndrg2), serotonin (5-HT), delta like canonical Notch ligand 1 (DLL1), NOD-like receptor thermal protein domain associated 3 (NLRP3), etc. addition, act on response element (ERE) fragment genes estrogenic β-amyloid precursor cleavase (BACE1). However, there few studies relationship between exercise, signaling pathway, disorders. Hence, we how mediates mechanism We aim provide theoretical perspective for affecting female health support design prescriptions.

Язык: Английский

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Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14686 - 14686

Опубликована: Сен. 28, 2023

Alzheimer’s disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as powerful tool for reducing chronic inflammation, improving overall health, preventing decline. The connection between the immune system, gut microbiota (GM), neuroinflammation highlights role gut–brain axis in maintaining brain health diseases. Neglected so far, PE beneficial effects on microbial composition diversity, thus providing potential to alleviate neurological There bidirectional communication muscle, with GM diversity modulation short-chain fatty acid (SCFA) production affecting muscle metabolism preservation, activity/exercise turn inducing significant changes composition, functionality, SCFA production. This gut–muscle muscle–gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity function through BDNF signaling. Irisin muscle-generated may mediate positive physical activity against some aspects AD pathophysiology interaction ecosystem, neural plasticity, anti-inflammatory signaling pathways, neurogenesis. Understanding gut–muscle–brain interconnections hold promise developing strategies promote fight age-associated decline, improve longevity.

Язык: Английский

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A Bibliometric Analysis on the Research Trend of Exercise and the Gut Microbiome

Microorganisms, Год журнала: 2023, Номер 11(4), С. 903 - 903

Опубликована: Март 30, 2023

This article aims to provide an overview of research hotspots and trends in exercise the gut microbiome, a field which has recently gained increasing attention. The relevant publications on microbiome were identified from Web Science Core Collection database. publication types limited articles reviews. VOSviewer 1.6.18 (Centre for Technology Studies, Leiden University, Leiden, Netherlands) R package “bibliometrix” (R Foundation: Vienna, Austria) used conduct bibliometric analysis. A total 327 eligible eventually identified, including 245 original 82 time trend analysis showed that number rapidly increased after 2014. leading countries/regions this USA, China, Europe. Most active institutions Europe USA. Keyword relationship between disease, occurs throughout development research. interactions microbiota, exercise, status host’s internal environment, probiotics, are important facets as well. topic evolution presents multidisciplinary multi-perspective comprehensive Exercise might become effective intervention disease treatment by regulating microbiome. innovation exercise-centered lifestyle therapy may significant future.

Язык: Английский

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Applied physiology: gut microbiota and antimicrobial therapy

European Journal of Applied Physiology, Год журнала: 2024, Номер 124(6), С. 1631 - 1643

Опубликована: Апрель 29, 2024

Язык: Английский

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Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood. This study sought to understand dietary habits, gut microbiota composition, etc. among individuals with SD investigate their association occurrence. Employing a cross-sectional approach, 178 SD, aged 18–32 years, were matched 114 healthy counterparts. status was evaluated using Zung Self-rating Depression Scale (SDS), Anxiety (SAS), Beck Inventory 2nd version (BDI-II), 17-item Hamilton Rating Scales (HAMD-17), Pittsburgh Sleep Quality Index (PSQI). Metagenomic sequencing utilized identify fecal microbial profiles. Dietary patterns discerned via factor analysis 25-item food frequency questionnaire (FFQ). Logistic regression mediation performed explore potential links microbiota, patterns, incident SD. Data on habits available for 292 participants (mean [SD] age, 22.1 [2.9] years; 216 [73.9 %] female). revealed that Ⅰ (odds ratio [OR], 0.34; 95 % CI, 0.15–0.75) IV (OR, 0.39; 0.17–0.86 OR, 0.18–0.84) associated reduced risk Distinct profiles observed marked by increased diversity taxonomic alterations. Moreover, suggested Veillonella atypica as mediator linking SDS or BDI-II scores pattern rich bean products, coarse grains, nuts, fruits, mushrooms, potatoes (β = 0.25, CI: 0.02–0.78 β 0.18, 0.01–0.54). Our findings highlight complex developing adults, underscoring interventions microbiome modulation mental health promotion.

Язык: Английский

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