Foods, Год журнала: 2024, Номер 13(16), С. 2548 - 2548
Опубликована: Авг. 15, 2024
Probiotics are live microorganisms that, when consumed in sufficient quantities, offer numerous health benefits to the host [...].
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 3010 - 3010
Опубликована: Март 5, 2024
This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.
Язык: Английский
Процитировано
17
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
7
Nutrients, Год журнала: 2023, Номер 15(20), С. 4365 - 4365
Опубликована: Окт. 13, 2023
This systematic review aims to provide a comprehensive understanding of the current literature regarding gut microbiota composition in patients with Parkinson’s disease (PD) and Alzheimer’s (AD) compared healthy controls. To identify relevant studies, thorough search PubMed, Medline, Embase was conducted following PRISMA guidelines. Out 5627 articles, 73 studies were assessed for full-text eligibility, which led inclusion 42 (26 PD 16 AD studies). The risk bias assessment showed medium 32 (20 12 studies), low 9 (5 4 1 study high risk. Among 22 out 26 reported different between cases controls, 15 differences consistently identified phyla Bacteroidetes, Firmicutes, Proteobacteria as prevalent both groups case groups. Microbial dysbiosis specifically characterized by abundance Akkermansia, Verrucomicrobiaceae, Lachnospiraceae, Ruminococcaceae Blautia, Coprococcus, Prevotellaceae, Roseburia Similarly, Bacteroides Acidobacteriota abundant cases, Acidaminococcaceae, Ruminiclostridium microbial signature association several taxa, including Bifidobacterium, Ruminococcacea, Verrucomicrobia Ruminococcaceae, Bacteroides, Actinobacteria AD. diversity evaluations indicated comparable alpha some distinct others, consistent beta controls across multiple studies. bacterial signatures this that are associated may offer promising prospects efficient management treatment approaches.
Язык: Английский
Процитировано
31
Biomedicines, Год журнала: 2023, Номер 11(10), С. 2793 - 2793
Опубликована: Окт. 14, 2023
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), well a seemingly distinct Niemann-Pick type C with primarily juvenile onset. This strongly argues for an overlap pathogenic mechanisms. The commonly researched include various cell subsets, microglia, peripheral macrophages, regulatory T cells (Tregs); the complement system; other soluble factors. In this review, we compare these diseases from clinical point of view highlight common pathways mechanisms protein aggregation, neurodegeneration, and/or neuroinflammation that could potentially lead to shared treatment strategies overlapping dysfunctions diseases. These approaches but not limited immunisation, cascade blockade, microbiome regulation, inhibition signal transduction, Treg boosting, stem transplantation.
Язык: Английский
Процитировано
26
Food Bioengineering, Год журнала: 2024, Номер 3(1), С. 126 - 147
Опубликована: Март 1, 2024
Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.
Язык: Английский
Процитировано
7
Life Sciences, Год журнала: 2024, Номер 350, С. 122748 - 122748
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
7
Food & Function, Год журнала: 2024, Номер 15(5), С. 2668 - 2678
Опубликована: Янв. 1, 2024
Bifidobacterium animalis subsp. lactis A6 ameliorated hippocampal damage and memory impairments in an ADHD rat model by reshaping the gut microbiota composition, alleviating neuron loss inflammation, regulating neurotransmitter release.
Язык: Английский
Процитировано
6
Опубликована: Сен. 13, 2023
Many of the potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), but also a seemingly distinct Niemann-Pick type C with primarily juvenile-onset. This strongly argues for an overlap pathogenic mechanisms. The commonly researched include various cell subsets microglia, peripheral macrophages, or regulatory T cells (Tregs), complement system, other soluble factors. In this review, we will compare these from clinical point view out common pathways mechanisms protein aggregation, neurodegeneration and/or neuroinflammation that could potentially lead to shared treatment strategies. We describe approaches treating dysfunctions disorders, moving immunization microbiome regulation stem treatment.
Язык: Английский
Процитировано
13
Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
5
Biomolecules, Год журнала: 2024, Номер 14(8), С. 1017 - 1017
Опубликована: Авг. 16, 2024
Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health contribute substantial economic burden worldwide. Especially, social disorganization inequality) associated childhood adversity has long-lasting effects on mental health, increasing the risk of developing disorders. Intestinal bacteria, functionally as an endocrine organ second brain, release various immunomodulators bioactive compounds directly or indirectly regulating host’s physiological behavioral homeostasis. Under challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading neuroinflammation neuronal injury, eventually aggressive, violent, impulsive behavior in humans animals via complex bidirectional communication microbiota–gut–brain (MGB) axis. The dysregulation MGB axis also been recognized one reasons for prevalence injurious behaviors (feather pecking, aggression, cannibalistic pecking) chickens. However, existing knowledge preventing treating these both chickens is not well understood. In previous studies, we developed non-mammal model abnormal investigation by rationalizing microbiota Based our earlier success, perspective article outlines possibility reducing through modifying cecal transplantation, potential providing biotherapeutic rationale among individuals restoring diversity function.
Язык: Английский
Процитировано
4