Microorganisms,
Год журнала:
2023,
Номер
11(3), С. 793 - 793
Опубликована: Март 20, 2023
Background:
Quorum
sensing
(QS)
is
a
cell-to-cell
communication
mechanism
that
occurs
between
inter-
and
intra-bacterial
species
regulated
by
signaling
molecules
called
autoinducers
(AIs).
It
has
been
suggested
probiotics
can
exert
QS
inhibitory
effect
through
their
metabolites.
Purpose:
To
provide
an
overview
of
(1)
the
anti-QS
activity
its
against
foodborne
pathogenic
spoilage
bacteria;
(2)
potential
role
in
gut
health;
(3)
impact
microencapsulation
on
QS.
Results:
Lactobacillus
have
extensively
studied
for
found
to
effectively
disrupt
vitro.
However,
effectiveness
food
matrix
yet
be
determined
as
they
interfere
with
AI
receptor
or
synthesis.
plays
important
both
biofilm
formation
bacteria.
Moreover,
vitro
animal
studies
shown
modulate
cytokine
responses
dysbiosis
maintain
intestinal
barrier
function.
In
this
scenario,
was
enhance
activity.
underlying
remains
unclear.
Conclusions:
Probiotics
are
candidates
block
Microencapsulation
increases
efficacy.
more
research
still
needed
identification
metabolites
from
elucidation
(microcapsules
free
cells)
human
gut.
Metabolites,
Год журнала:
2023,
Номер
13(5), С. 625 - 625
Опубликована: Май 2, 2023
Due
to
the
continued
emergence
of
resistance
and
a
lack
new
promising
antibiotics,
bacterial
infection
has
become
major
public
threat.
High-throughput
screening
(HTS)
allows
rapid
large
collection
molecules
for
bioactivity
testing
holds
promise
in
antibacterial
drug
discovery.
More
than
50%
antibiotics
that
are
currently
available
on
market
derived
from
natural
products.
However,
with
easily
discoverable
being
found,
finding
sources
seen
limited
success.
Finding
activity
also
proven
be
challenging.
In
addition
exploring
products
synthetic
biology,
omics
technology
helped
study
biosynthetic
machinery
existing
enabling
construction
unnatural
synthesizers
bioactive
identification
molecular
targets
agents.
On
other
hand,
newer
smarter
strategies
have
been
continuously
pursued
screen
molecule
libraries
druggable
targets.
Biomimetic
conditions
explored
mimic
real
model
better
ligand–target
interaction
enable
designing
more
effective
drugs.
This
narrative
review
describes
various
traditional
contemporaneous
approaches
high-throughput
It
further
discusses
critical
factors
HTS
assay
design,
makes
general
recommendation,
possible
alternatives
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 225 - 257
Опубликована: Май 7, 2024
The
number
of
multi-drug-resistant
bacteria
has
increased
over
the
last
few
decades,
which
caused
a
detrimental
impact
on
public
health
worldwide.
In
resolving
antibiotic
resistance
development
among
different
bacterial
communities,
new
antimicrobial
agents
and
nanoparticle-based
strategies
need
to
be
designed
foreseeing
slow
discovery
functioning
antibiotics.
Advanced
research
studies
have
revealed
significant
disinfection
potential
two-dimensional
nanomaterials
(2D
NMs)
severed
as
effective
antibacterial
due
their
unique
physicochemical
properties.
This
review
covers
current
progress
2D
NMs-based
based
an
inclusive
explanation
NMs'
agents,
including
detailed
introduction
each
possible
well-known
mechanism.
properties
NMs
activities
been
deliberated
while
explaining
toxic
effects
discussing
biomedical
significance,
dysbiosis,
cellular
nanotoxicity.
Adding
challenges,
we
also
discussed
major
issues
regarding
quality
availability
nanotoxicity
data.
However,
smart
advancements
are
required
fabricate
biocompatible
exploit
combat
clinically.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 5, 2024
Abstract
Sharing
of
genetic
elements
among
different
pathogens
and
commensals
inhabiting
same
hosts
environments
has
significant
implications
for
antimicrobial
resistance
(AMR),
especially
in
settings
with
high
exposure.
We
analysed
661
Escherichia
coli
Salmonella
enterica
isolates
collected
within
across
environments,
10
Chinese
chicken
farms
over
2.5
years
using
data-mining
methods.
Most
possessed
the
clinically
relevant
AMR-carrying
mobile
(plasmids:
70.6%,
transposons:
78%),
which
also
showed
recent
common
evolution.
Supervised
machine
learning
classifiers
revealed
known
novel
AMR-associated
mutations
genes
underlying
to
28
antimicrobials,
primarily
associated
E.
susceptibility
S.
.
Many
were
essential
affected
metabolic
processes
both
species,
albeit
varying
degrees
phylogenetic
penetration.
Multi-modal
strategies
are
crucial
investigate
interplay
mobilome,
metabolism
cohabiting
bacteria,
ecological
where
community-driven
selection
occurs.
Microorganisms,
Год журнала:
2022,
Номер
10(2), С. 350 - 350
Опубликована: Фев. 3, 2022
The
modern
paradigm
assumes
that
interspecies
communication
of
microorganisms
occurs
through
precise
regulatory
mechanisms.
In
particular,
antagonism
between
bacteria
or
and
fungi
can
be
achieved
by
direct
destruction
the
targeted
cells
regulated
production
antimicrobial
metabolites
controlling
their
adaptive
mechanisms,
such
as
formation
biofilms.
quorum-quenching
phenomenon
provides
a
countermeasure
strategy.
This
review
discusses
quorum-sensing
suppression
Gram-positive
microorganisms,
underlying
mechanisms
this
process,
its
molecular
intermediates.
main
focus
will
on
have
practical
applications,
starter
cultures
for
food
fermentation,
probiotics,
other
biotechnological
importance.
possible
evolutionary
role
during
development
interactions
is
also
considered.
addition,
applications
these
control
pathogens,
improving
efficiency
plant
protection.
Bioactive Materials,
Год журнала:
2022,
Номер
16, С. 249 - 270
Опубликована: Март 3, 2022
Microbial
resistance
to
current
antibiotics
therapies
is
a
major
cause
of
implant
failure
and
adverse
clinical
outcomes
in
orthopaedic
surgery.
Recent
developments
advanced
antimicrobial
nanotechnologies
provide
numerous
opportunities
effective
remove
resistant
bacteria
prevent
from
occurring
through
unique
mechanisms.
With
tunable
physicochemical
properties,
nanomaterials
can
be
designed
bactericidal,
antifouling,
immunomodulating,
capable
delivering
antibacterial
compounds
the
infection
region
with
spatiotemporal
accuracy.
Despite
its
substantial
advancement,
an
important,
but
under-explored
area,
potential
microbial
how
this
impact
use
nanotechnologies.
This
review
aims
better
understanding
nanomaterial-associated
accelerate
bench-to-bedside
translations
emerging
for
control
associated
infections.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Янв. 7, 2022
Abstract
Pseudomonas
aeruginosa
is
an
opportunistic
bacterium
causing
several
health
problems
and
having
many
virulence
factors
like
biofilm
formation
on
different
surfaces.
There
a
significant
need
to
develop
new
antimicrobials
due
the
spreading
resistance
commonly
used
antibiotics,
partly
attributed
formation.
Consequently,
this
study
aimed
investigate
anti-biofilm
anti-quorum
sensing
activities
of
Dioon
spinulosum,
Dyer
Ex
Eichler
extract
(DSE),
against
clinical
isolates.
DSE
exhibited
reduction
in
by
P.
isolates
both
vitro
vivo
rat
models.
It
also
resulted
decrease
cell
surface
hydrophobicity
exopolysaccharide
quantity
Both
bright
field
scanning
electron
microscopes
provided
evidence
for
inhibiting
ability
Moreover,
it
reduced
violacein
production
Chromobacterium
violaceum
(ATCC
12,472).
decreased
relative
expression
4
quorum
genes
(
las
I,
R,
rhl
R)
gene
ndv
B)
using
qRT-PCR.
Furthermore,
presented
cytotoxic
activity
with
IC
50
4.36
±
0.52
µg/ml
human
skin
fibroblast
lines.
For
first
time,
reports
that
promising
resource
agents.
