Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health DOI Creative Commons

Mohammed Kamal Salman,

Jumana Abuqwider, Gianluigi Mauriello

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(3), P. 793 - 793

Published: March 20, 2023

Background: Quorum sensing (QS) is a cell-to-cell communication mechanism that occurs between inter- and intra-bacterial species regulated by signaling molecules called autoinducers (AIs). It has been suggested probiotics can exert QS inhibitory effect through their metabolites. Purpose: To provide an overview of (1) the anti-QS activity its against foodborne pathogenic spoilage bacteria; (2) potential role in gut health; (3) impact microencapsulation on QS. Results: Lactobacillus have extensively studied for found to effectively disrupt vitro. However, effectiveness food matrix yet be determined as they interfere with AI receptor or synthesis. plays important both biofilm formation bacteria. Moreover, vitro animal studies shown modulate cytokine responses dysbiosis maintain intestinal barrier function. In this scenario, was enhance activity. underlying remains unclear. Conclusions: Probiotics are candidates block Microencapsulation increases efficacy. more research still needed identification metabolites from elucidation (microcapsules free cells) human gut.

Language: Английский

High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery DOI Creative Commons
Navid J. Ayon

Metabolites, Journal Year: 2023, Volume and Issue: 13(5), P. 625 - 625

Published: May 2, 2023

Due to the continued emergence of resistance and a lack new promising antibiotics, bacterial infection has become major public threat. High-throughput screening (HTS) allows rapid large collection molecules for bioactivity testing holds promise in antibacterial drug discovery. More than 50% antibiotics that are currently available on market derived from natural products. However, with easily discoverable being found, finding sources seen limited success. Finding activity also proven be challenging. In addition exploring products synthetic biology, omics technology helped study biosynthetic machinery existing enabling construction unnatural synthesizers bioactive identification molecular targets agents. On other hand, newer smarter strategies have been continuously pursued screen molecule libraries druggable targets. Biomimetic conditions explored mimic real model better ligand–target interaction enable designing more effective drugs. This narrative review describes various traditional contemporaneous approaches high-throughput It further discusses critical factors HTS assay design, makes general recommendation, possible alternatives

Language: Английский

Citations

45
Mode of Action of Biogenic Silver, Zinc, Copper, Titanium and Cobalt Nanoparticles Against Antibiotics Resistant Pathogens DOI
Muhammad Summer, Shaukat Ali, Hafiz Muhammad Tahir

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(4), P. 1417 - 1451

Published: Jan. 9, 2024

Language: Английский

Citations

29
Emerging trends and future challenges of advanced 2D nanomaterials for combating bacterial resistance DOI Creative Commons
S. F. Hameed, Sumaira Sharif, Muhammad Ovais

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 225 - 257

Published: May 7, 2024

The number of multi-drug-resistant bacteria has increased over the last few decades, which caused a detrimental impact on public health worldwide. In resolving antibiotic resistance development among different bacterial communities, new antimicrobial agents and nanoparticle-based strategies need to be designed foreseeing slow discovery functioning antibiotics. Advanced research studies have revealed significant disinfection potential two-dimensional nanomaterials (2D NMs) severed as effective antibacterial due their unique physicochemical properties. This review covers current progress 2D NMs-based based an inclusive explanation NMs' agents, including detailed introduction each possible well-known mechanism. properties NMs activities been deliberated while explaining toxic effects discussing biomedical significance, dysbiosis, cellular nanotoxicity. Adding challenges, we also discussed major issues regarding quality availability nanotoxicity data. However, smart advancements are required fabricate biocompatible exploit combat clinically.

Language: Английский

Citations

18
Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China DOI Creative Commons
Michelle Baker, Xibin Zhang, Alexandre Maciel-Guerra

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 5, 2024

Abstract Sharing of genetic elements among different pathogens and commensals inhabiting same hosts environments has significant implications for antimicrobial resistance (AMR), especially in settings with high exposure. We analysed 661 Escherichia coli Salmonella enterica isolates collected within across environments, 10 Chinese chicken farms over 2.5 years using data-mining methods. Most possessed the clinically relevant AMR-carrying mobile (plasmids: 70.6%, transposons: 78%), which also showed recent common evolution. Supervised machine learning classifiers revealed known novel AMR-associated mutations genes underlying to 28 antimicrobials, primarily associated E. susceptibility S. . Many were essential affected metabolic processes both species, albeit varying degrees phylogenetic penetration. Multi-modal strategies are crucial investigate interplay mobilome, metabolism cohabiting bacteria, ecological where community-driven selection occurs.

Language: Английский

Citations

17
Metagenomic profiles and health risks of pathogens and antibiotic resistance genes in various industrial wastewaters and the associated receiving surface water DOI
Yao Tang, Zhishu Liang, Guiying Li

et al.

Chemosphere, Journal Year: 2021, Volume and Issue: 283, P. 131224 - 131224

Published: June 16, 2021

Language: Английский

Citations

67
Quorum-Sensing Inhibition by Gram-Positive Bacteria DOI Creative Commons
Evgeniya V. Prazdnova, Andrey Gorovtsov, Nikita Vasilchenko

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(2), P. 350 - 350

Published: Feb. 3, 2022

The modern paradigm assumes that interspecies communication of microorganisms occurs through precise regulatory mechanisms. In particular, antagonism between bacteria or and fungi can be achieved by direct destruction the targeted cells regulated production antimicrobial metabolites controlling their adaptive mechanisms, such as formation biofilms. quorum-quenching phenomenon provides a countermeasure strategy. This review discusses quorum-sensing suppression Gram-positive microorganisms, underlying mechanisms this process, its molecular intermediates. main focus will on have practical applications, starter cultures for food fermentation, probiotics, other biotechnological importance. possible evolutionary role during development interactions is also considered. addition, applications these control pathogens, improving efficiency plant protection.

Language: Английский

Citations

64
Microbial resistance to nanotechnologies: An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants DOI Creative Commons
Zhuoran Wu, Brian Chan, Jessalyn Low

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 16, P. 249 - 270

Published: March 3, 2022

Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery. Recent developments advanced antimicrobial nanotechnologies provide numerous opportunities effective remove resistant bacteria prevent from occurring through unique mechanisms. With tunable physicochemical properties, nanomaterials can be designed bactericidal, antifouling, immunomodulating, capable delivering antibacterial compounds the infection region with spatiotemporal accuracy. Despite its substantial advancement, an important, but under-explored area, potential microbial how this impact use nanotechnologies. This review aims better understanding nanomaterial-associated accelerate bench-to-bedside translations emerging for control associated infections.

Language: Английский

Citations

58
Quorum sensing inhibitors applications: A new prospect for mitigation of microbiologically influenced corrosion DOI
Asma Lamin, Anna H. Kaksonen, Ivan Cole

et al.

Bioelectrochemistry, Journal Year: 2022, Volume and Issue: 145, P. 108050 - 108050

Published: Jan. 5, 2022

Language: Английский

Citations

47
Histological assessment, anti-quorum sensing, and anti-biofilm activities of Dioon spinulosum extract: in vitro and in vivo approach DOI Creative Commons
Engy Elekhnawy, Walaa A. Negm, Mona El‐Aasr

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 7, 2022

Abstract Pseudomonas aeruginosa is an opportunistic bacterium causing several health problems and having many virulence factors like biofilm formation on different surfaces. There a significant need to develop new antimicrobials due the spreading resistance commonly used antibiotics, partly attributed formation. Consequently, this study aimed investigate anti-biofilm anti-quorum sensing activities of Dioon spinulosum, Dyer Ex Eichler extract (DSE), against clinical isolates. DSE exhibited reduction in by P. isolates both vitro vivo rat models. It also resulted decrease cell surface hydrophobicity exopolysaccharide quantity Both bright field scanning electron microscopes provided evidence for inhibiting ability Moreover, it reduced violacein production Chromobacterium violaceum (ATCC 12,472). decreased relative expression 4 quorum genes ( las I, R, rhl R) gene ndv B) using qRT-PCR. Furthermore, presented cytotoxic activity with IC 50 4.36 ± 0.52 µg/ml human skin fibroblast lines. For first time, reports that promising resource agents.

Language: Английский

Citations

38
A review of chemical signaling pathways in the quorum sensing circuit of Pseudomonas aeruginosa DOI
Kayeen Vadakkan, Ajit Kumar Ngangbam, Kuppusamy Sathishkumar

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127861 - 127861

Published: Nov. 7, 2023

Language: Английский

Citations

35