Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

ACS Chemical Neuroscience, Год журнала: 2023, Номер 14(10), С. 1717 - 1763

Опубликована: Май 8, 2023

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that gut and brain are in constant bidirectional communication, which its metabolic production major component, form so-called microbiome–brain axis. Disturbances homeostasis caused by imbalance their functional composition activities, known as dysbiosis, cause dysregulation these pathways trigger changes blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological disorders. In turn, can affect structure function through autonomic nervous system regulating motility, intestinal transit secretion, permeability. Here, we examine data from CAS Content Collection, largest published scientific information, analyze publication landscape recent research. We review advances knowledge related to human microbiome, complexity functionality, communication with central system, effect axis on mental health. discuss correlations between various diseases, specifically also explore metabolites regard impact associated diseases. Finally, assess clinical applications gut-microbiota-related substances development pipelines. hope this serve useful resource understanding current emerging field an effort further solving remaining challenges fulfilling potential.

Язык: Английский

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Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options

Pharmaceuticals, Год журнала: 2023, Номер 16(4), С. 565 - 565

Опубликована: Апрель 9, 2023

The gut microbiota is critical for maintaining human health and the immunological system. Several neuroscientific studies have shown significance of in developing brain systems. are interconnected a bidirectional relationship, as research on microbiome–gut–brain axis shows. Significant evidence links anxiety depression disorders to community microbes that live gastrointestinal Modified diet, fish omega-3 fatty acid intake, macro- micro-nutrient prebiotics, probiotics, synbiotics, postbiotics, fecal transplantation, 5-HTP regulation may all be utilized alter treatment approach. There few preclinical clinical effectiveness reliability various therapeutic approaches anxiety. This article highlights relevant association with different possibilities modification.

Язык: Английский

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The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets

Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown, С. 108825 - 108825

Опубликована: Фев. 1, 2025

Язык: Английский

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Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain–gut–microbiota axis via the subdiaphragmatic vagus nerve

Journal of Affective Disorders, Год журнала: 2021, Номер 292, С. 565 - 573

Опубликована: Июнь 11, 2021

Язык: Английский

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The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights

Nutrients, Год журнала: 2023, Номер 15(6), С. 1496 - 1496

Опубликована: Март 20, 2023

There is growing interest in the role that intestinal microbiota and related autoimmune processes may have genesis presentation of some psychiatric diseases. An alteration communication microbiota-gut-brain axis, which constitutes a communicative model between central nervous system (CNS) gastro-enteric tract, has been identified as one possible causes The purpose this narrative review to describe evidence supporting gut diseases impact diet on mental health. Change composition could determine an increase permeability barrier, leading cytokine storm. This trigger systemic inflammatory activation immune response: series events repercussions release neurotransmitters, altering activity hypothalamic-pituitary-adrenal reducing presence trophic brain factors. Although disorders seem be connected, more effort needed understand potential causative mechanisms underlying interactions these systems.

Язык: Английский

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An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2023, Номер 128, С. 110861 - 110861

Опубликована: Сен. 9, 2023

There is a lot of evidence establishing that nervous system development related to the composition and functions gut microbiome. In addition, central (CNS) controls imbalance intestinal microbiota, constituting bidirectional communication system. At present, various gut-brain crosstalk routes have been described, including immune, endocrine neural circuits via vagal pathway. Several empirical data associated microbiota alterations (dysbiosis) with neuropsychiatric diseases, such as Alzheimer's disease, autism Parkinson's other psychological disorders, like anxiety depression. Fecal transplantation (FMT) therapy has shown can transfer behavioral features recipient animals, which provides strong establish causal-effect relationship. Interventions, based on prebiotics, probiotics or synbiotics, demonstrated an important influence neurological disorders by synthesis neuroactive compounds interact regulation inflammatory processes. Further research needed demonstrate dysbiosis psychiatric how microbiota-based interventions may be used potential therapeutic tools.

Язык: Английский

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The Role of Probiotics and Their Metabolites in the Treatment of Depression

Molecules, Год журнала: 2023, Номер 28(7), С. 3213 - 3213

Опубликована: Апрель 4, 2023

Depression is a common and complex mental emotional disorder that causes disability, morbidity, quite often mortality around the world. closely related to several physical metabolic conditions causing depression. Studies have indicated there relationship between intestinal microbiota brain, known as gut–brain axis. While this microbiota–gut–brain connection disturbed, dysfunctions of immune system, endocrine gastrointestinal tract occur. Numerous studies show dysbiosis characterized by abnormal dysfunction axis could be direct cause disorders. Traditional treatment depression includes psychotherapy pharmacotherapy, it mainly targets brain. However, restoration functions via using probiotics, their metabolites, prebiotics, healthy diet may alleviate depressive symptoms. Administration probiotics labeled psychobiotics metabolites metabiotics, especially an adjuvant antidepressants, improves It new approach prevention, management, illnesses, particularly major For effectiveness antidepressant therapy, should administered at dose higher than 1 billion CFU/day for least 8 weeks.

Язык: Английский

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Probiotics, Live Biotherapeutic Products (LBPs), and Gut-Brain Axis Related Psychological Conditions: Implications for Research and Dietetics

Probiotics and Antimicrobial Proteins, Год журнала: 2023, Номер 15(4), С. 1014 - 1031

Опубликована: Май 24, 2023

Язык: Английский

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Assessment of Quality of Life Among Patients With Recurrent Clostridioides difficile Infection Treated with Investigational Oral Microbiome Therapeutic SER-109

JAMA Network Open, Год журнала: 2023, Номер 6(1), С. e2253570 - e2253570

Опубликована: Янв. 30, 2023

Importance Recurrent Clostridioides difficile infection (CDI) is a debilitating disease leading to poor health-related quality of life (HRQOL), loss productivity, anxiety, and depression. The potential association treatment with HRQOL has not been well evaluated. Objectives To explore the SER-109 compared placebo on in patients recurrent CDI up week 8. Design, Setting, Participants This study was secondary analysis randomized, double-blind, placebo-controlled trial that took place at 56 sites US Canada from July 2017 April 2020 included 182 randomized or groups. Interventions (4 capsules once daily for 3 days) following antibiotics CDI. Main Outcomes Measures Exploratory using specific Quality Life Survey (Cdiff32) assessed baseline, 1, Results In this study, (109 [59.9%] female; mean age, 65.5 [16.5] years) were (89 [48.9%]) (93 [51.1%]) groups primary exploratory analyses. Baseline Cdiff32 scores similar between (52.0 [18.3] vs 52.8 [18.7], respectively). proportion overall improvement baseline total score higher arm than 1 (49.4% 26.9%; P = .012) 8 (66.3% 48.4%; .001).Greater improvements physical domain subdomain observed group as early continued Among group, primarily nonrecurrent while reported HRQOL, regardless clinical outcome. Conclusions Relevance phase trial, SER-109, an investigational microbiome therapeutic associated rapid steady through weeks, important patient-reported Trial Registration ClinicalTrials.gov Identifier: NCT03183128

Язык: Английский

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The current state of research for psychobiotics use in the management of psychiatric disorders–A systematic literature review

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Фев. 23, 2023

The need to find new therapeutic interventions in patients diagnosed with psychiatric disorders is supported by the data suggesting high rates of relapse, chronic evolution, resistance, or lack adherence and disability. use pre-, pro-, synbiotics as add-ons management has been explored a way augment efficacy psychotropics improve chances for these reach response remission. This systematic literature review focused on tolerability psychobiotics main categories it conducted through most important electronic databases clinical trial registers, using PRISMA 2020 guidelines. quality primary secondary reports was assessed criteria identified Academy Nutrition Diabetics. Forty-three sources, mostly moderate quality, were reviewed detail, regarding assessed. Studies exploring effects mood disorders, anxiety schizophrenia spectrum substance eating attention deficit hyperactivity disorder (ADHD), neurocognitive autism (ASD) included. overall good, but evidence support their specific mixed. There have favor probiotics ADHD, ASD, also association selenium disorders. In several domains, research still an early phase development, e.g., (only three preclinical studies being found) (one identified). Although no well-defined recommendation could yet be formulated product there encouraging further research, especially if identification sub-populations that may benefit from this intervention. Several limitations field should addressed, i.e., majority finalized trials are short duration, inherent heterogeneity diversity Philae prevents generalizability results studies.

Язык: Английский

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