Brain Research Bulletin,
Год журнала:
2022,
Номер
182, С. 44 - 56
Опубликована: Фев. 11, 2022
Depression
is
the
most
common
mental
disorder
and
a
leading
cause
of
disability
worldwide.
Despite
abundant
research,
precise
mechanisms
underlying
pathophysiology
depression
remain
elusive.
Accumulating
evidence
from
preclinical
clinical
studies
suggests
that
alterations
in
gut
microbiota,
microbe-derived
short-chain
fatty
acids,
D-amino
acids
metabolites
play
key
role
via
brain–gut–microbiota
axis,
including
neural
immune
systems.
Notably,
axis
might
crucial
susceptibility
versus
resilience
rodents
exposed
to
stress.
Vagotomy
reported
block
depression-like
phenotypes
after
fecal
microbiota
transplantation
"depression-related"
microbiome,
suggesting
vagus
nerve
influences
through
axis.
In
this
article,
we
review
recent
findings
regarding
discuss
its
potential
as
therapeutic
target
for
depression.
Brain Research Bulletin,
Год журнала:
2022,
Номер
182, С. 130 - 140
Опубликована: Фев. 12, 2022
The
spleen,
an
important
tissue
for
the
immune
system,
acts
as
a
filter
blood
within
system.
Accumulating
evidence
suggests
that
spleen
affects
number
of
brain
functions
in
health
and
diseases
via
modulation.
Systemic
inflammation
or
chronic
social
defeat
stress
(CSDS)
can
cause
splenomegaly
rodents.
Interestingly,
new
antidepressant
arketamine
could
normalize
depression-like
behaviors
CSDS-susceptible
mice.
A
recent
study
strongly
supports
direct
connection
pathway
between
whereby
regulate
humoral
defense
by
two
regions,
such
corticotropin-related
neurons
paraventricular
nucleus
(PVN)
central
amygdala
(CeA).
Furthermore,
afferent
efferent
vagus
nerve
signaling
may
contribute
to
communication.
In
this
article,
we
review
findings
brain-spleen
axis
diseases.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(9), С. 3625 - 3637
Опубликована: Сен. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(4), С. 565 - 565
Опубликована: Апрель 9, 2023
The
gut
microbiota
is
critical
for
maintaining
human
health
and
the
immunological
system.
Several
neuroscientific
studies
have
shown
significance
of
in
developing
brain
systems.
are
interconnected
a
bidirectional
relationship,
as
research
on
microbiome–gut–brain
axis
shows.
Significant
evidence
links
anxiety
depression
disorders
to
community
microbes
that
live
gastrointestinal
Modified
diet,
fish
omega-3
fatty
acid
intake,
macro-
micro-nutrient
prebiotics,
probiotics,
synbiotics,
postbiotics,
fecal
transplantation,
5-HTP
regulation
may
all
be
utilized
alter
treatment
approach.
There
few
preclinical
clinical
effectiveness
reliability
various
therapeutic
approaches
anxiety.
This
article
highlights
relevant
association
with
different
possibilities
modification.
Translational Psychiatry,
Год журнала:
2021,
Номер
11(1)
Опубликована: Ноя. 8, 2021
Abstract
Major
depressive
disorder
(MDD)
is
a
serious
mental
illness.
Increasing
evidence
from
both
animal
and
human
studies
suggested
that
the
gut
microbiota
might
be
involved
in
onset
of
depression
via
gut–brain
axis.
However,
mechanism
remains
unclear.
To
explore
protein
changes
axis
modulated
by
microbiota,
germ-free
mice
were
transplanted
with
MDD
patients
to
induce
depression-like
behaviors.
Behavioral
tests
performed
following
fecal
transplantation.
A
quantitative
proteomics
approach
was
used
examine
expression
prefrontal
cortex
(PFC),
liver,
cecum,
serum.
Then
differential
analysis
weighted
gene
coexpression
network
identify
microbiota-related
modules.
Our
results
induced
alteration
levels
multiple
tissues
phenotype,
these
PFC
liver
model
specific
compared
chronic
stress
models.
Gene
ontology
enrichment
revealed
variety
biological
functions,
including
metabolic
process
inflammatory
response,
which
energy
metabolism
core
change
network.
data
provide
clues
for
future
on
level
deepen
understanding
how
cause
Nutrients,
Год журнала:
2022,
Номер
14(14), С. 2945 - 2945
Опубликована: Июль 19, 2022
Evidence
linking
Faecalibacterium
prausnitzii
abundance
to
nonalcoholic
fatty
liver
disease
(NAFLD)
is
accumulating;
however,
the
causal
relationship
remains
obscure.
In
this
study,
12
F.
strains
were
orally
administered
high
fat
diet
fed
C57BL/6J
mice
for
weeks
evaluate
protective
effects
of
on
NAFLD.
We
found
that
five
strains,
A2-165,
LB8,
ZF21,
PL45,
and
LC49,
significantly
restored
serum
lipid
profiles
ameliorated
glucose
intolerance,
adipose
tissue
dysfunction,
hepatic
steatosis,
inflammation,
oxidative
stress
in
a
mouse
model
Moreover,
two
LC49
enhanced
short-chain
acid
(SCFA)
production
modulated
gut
microbiota.
Based
combined
analysis
linear
discriminant
effect
size
microbial
communities,
core
microbiome
related
NAFLD
comprised
Odoribacter,
Roseburia,
Erysipelatoclostridium,
Tyzzerella,
Faecalibaculum,
Blautia,
Acetatifactor,
last
genera
can
be
reversed
by
treatment
with
LB8
strains.
Additionally,
enriched
Lactobacillus,
Ileibacterium,
Faecalibacterium,
Dubosiella,
Bifidobacterium
downregulated
pathways
involving
carbohydrate
metabolism,
amino
biosynthesis.
Interestingly,
supplementation
also
upregulated
tryptophan
glutathione
valine,
leucine,
isoleucine
degradation,
which
might
prevention.
Collectively,
exerted
considerable
anti-NAFLD
microbiota-regulating
effects,
indicating
their
potential
as
probiotic
agents
treatment.
Frontiers in Neurology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 10, 2022
Depression
is
a
worldwide
disease
causing
severe
disability,
morbidity,
and
mortality.
Despite
abundant
studies,
the
precise
mechanisms
underlying
pathophysiology
of
depression
remain
elusive.
Recently,
cumulate
research
suggests
that
disturbance
microbiota-gut-brain
axis
may
play
vital
role
in
etiology
while
correcting
this
could
alleviate
symptoms.
The
vagus
nerve,
linking
brain
gut
through
its
afferent
efferent
branches,
critical
route
bidirectional
communication
axis.
Directly
or
indirectly,
fibers
can
sense
relay
microbiota
signals
to
induce
disorders
including
depression.
Also,
changes
response
stress
result
hyperpermeability
inflammation
mediating
by
vagal
efferents,
which
be
detrimental
Notably,
nerve
stimulation
owns
an
anti-inflammatory
effect
was
proved
for
treatment.
Nevertheless,
accompanied
low
tone,
derive
from
contribute
pathogenesis
In
review,
we
aim
explore
perspective
axis,
highlighting
relationship
among
hyperpermeability,
inflammation,
Neurobiology of Disease,
Год журнала:
2022,
Номер
165, С. 105635 - 105635
Опубликована: Янв. 24, 2022
Multiple
sclerosis
(MS)
is
the
most
common
demyelinating
disease
that
attacks
central
nervous
system.
We
recently
reported
new
antidepressant
(R)-ketamine
could
ameliorate
progression
in
experimental
autoimmune
encephalomyelitis
model
of
MS.
Cuprizone
(CPZ)
has
been
used
to
produce
demyelination
which
resembles
MS
patients.
This
study
was
undertaken
investigate
whether
affect
CPZ-treated
mice
and
remyelination
after
CPZ
withdrawal.
Repeated
treatment
with
(10
mg/kg/day,
twice
weekly,
for
6
weeks)
significantly
ameliorated
activated
microglia
brain
compared
saline-treated
mice.
Furthermore,
pretreatment
ANA-12
(TrkB
antagonist)
blocked
beneficial
effects
on
The
16S
rRNA
analysis
showed
improved
abnormal
composition
gut-microbiota
decreased
levels
lactic
acid
In
addition,
there
were
significant
correlations
between
(or
microglial
activation)
relative
abundance
several
microbiome,
suggesting
a
link
gut
microbiota
brain.
Interestingly,
facilitate
conclusion,
suggests
through
TrkB
activation,
gut-microbiota-microglia
crosstalk
may
play
role
Therefore,
it
likely
be
therapeutic
drug
Life,
Год журнала:
2022,
Номер
12(2), С. 196 - 196
Опубликована: Янв. 28, 2022
Major
depressive
disorder
is
one
of
the
most
prevalent
mental
health
disorders.
Monoamine-based
antidepressants
were
first
drugs
developed
to
treat
major
disorder.
More
recently,
ketamine
and
other
analogues
introduced
as
fast-acting
antidepressants.
Unfortunately,
currently
available
therapeutics
are
inadequate;
lack
efficacy,
adverse
effects,
risks
leave
patients
with
limited
treatment
options.
Efforts
now
focused
on
understanding
etiology
depression
identifying
novel
targets
for
pharmacological
treatment.
In
this
review,
we
discuss
promising
Targeting
receptors
including
N-methyl-D-aspartate
receptors,
peroxisome
proliferator-activated
G-protein-coupled
receptor
39,
metabotropic
glutamate
galanin
opioid
has
potential
antidepressant
effects.
Compounds
targeting
biological
processes:
inflammation,
hypothalamic-pituitary-adrenal
axis,
cholesterol
biosynthesis
pathway,
gut
microbiota
have
also
shown
therapeutic
potential.
Additionally,
natural
products
plants,
herbs,
fatty
acids
improved
symptoms
behaviors.
a
brief
history
clinically
will
be
provided,
primary
focus
pharmaceutical
approaches
effects
in
preclinical
clinical
studies.
