International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 15632 - 15632
Опубликована: Дек. 9, 2022
Inflammatory
Bowel
Disease
(IBD)
is
a
chronic
gastrointestinal
disorder
characterized
by
periods
of
activity
and
remission.
IBD
includes
Crohn’s
disease
(CD)
ulcerative
colitis
(UC),
even
though
has
not
been
considered
as
heritable
disease,
there
are
genetic
variants
associated
with
increased
risk
for
the
disease.
5-Hydroxytriptamine
(5-HT),
or
serotonin,
exerts
wide
range
effects
under
both
normal
pathological
conditions.
Furthermore,
Serotonin
Transporter
(SERT)
coded
Solute
Carrier
Family
6
Member
4
(SLC6A4)
gene
(located
in
17q11.1-q12
chromosome),
possesses
variants,
such
Gene
Variable
Number
Tandem
Repeat
Intron
2
(STin2-VNTR)
Serotonin-Transporter-linked
promoter
region
(5-HTTLPR),
which
have
an
influence
over
functionality
SERT
re-uptake
bioavailability
serotonin.
The
intestinal
microbiota
crucial
actor
human
gut
physiology,
exerting
on
function,
inflammatory
processes.
As
consequence
abnormal
serotonin
signaling
function
these
processes,
use
selective
inhibitors
(SSRIs)
seen
to
improve
extraintestinal
manifestations,
depression
anxiety.
aim
this
study
integrate
scientific
data
linking
regulator
re-uptake,
well
its
role
pathogenesis
IBD.
We
performed
narrative
review,
including
literature
search
PubMed
database
review
original
articles
(no
date
restriction),
information
about
SLC6A4
obtained
from
Ensembl
website.
Scientific
evidence
vitro,
vivo,
clinical
trials
regarding
reuptake
adjuvant
therapy
patients
also
discussed.
A
total
194
were
used
between
reviews,
vitro
studies,
trials.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 27, 2024
Leptospirosis,
a
re-emerging
zoonotic
disease,
remains
significant
global
health
concern,
especially
amid
floods
and
disasters
such
as
the
Kakhovka
Dam
destruction.
As
is
known,
stress
that
occurs
in
conditions
of
military
conflicts
among
civilian
personnel
significantly
affects
susceptibility
to
infectious
diseases
possibly
even
influences
their
course.
This
review
aims
explore
how
gut
microbiome
mediators
(such
catecholamines
corticosteroids)
might
impact
leptospirosis
disease
The
opens
new
horizons
for
research
by
elucidating
connections
between
microbiome,
stress,
leptospirosis.
Antibiotics,
Год журнала:
2024,
Номер
13(5), С. 436 - 436
Опубликована: Май 12, 2024
Clostridioides
difficile
infection
(CDI)
is
an
intestinal
that
causes
morbidity
and
mortality
places
significant
burden
cost
on
the
healthcare
system,
especially
in
recurrent
cases.
Antibiotic
overuse
well
recognized
as
leading
cause
of
CDI
high-risk
patients,
studies
have
demonstrated
even
short-term
antibiotic
exposure
can
a
large
persistent
disturbance
to
human
colonic
microbiota.
The
recovery
sustainability
gut
microbiome
after
dysbiosis
been
associated
with
fewer
recurrences.
Fecal
microbiota
transplantation
(FMT)
refers
procedure
which
donor
stool
processed
transplanted
patient
CDI.
It
has
historically
used
patients
pseudomembranous
colitis
before
discovery
difficile.
More
recent
research
supports
use
FMT
part
standard
therapy
This
article
will
be
in-depth
review
five
therapeutic
products
are
either
under
investigation
or
currently
commercially
available:
Rebyota
(fecal
microbiota,
live-jslm,
formerly
RBX2660),
Vowst
spores,
live-brpk,
SER109),
VE303,
CP101,
RBX7455.
Included
this
comparison
products’
composition
dosage
forms,
available
safety
efficacy
data,
investigational
status.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3081 - 3081
Опубликована: Фев. 4, 2023
Depression
is
one
of
the
main
mental
disorders.
Pharmacological
treatment
depression
often
associated
with
delayed
effects
or
insufficient
efficacy.
Consequently,
there
a
need
to
discover
new
therapeutic
methods
cope
faster
and
more
effectively.
Several
lines
evidence
indicate
that
use
probiotic
therapy
reduces
depressive
symptoms.
Nonetheless,
exact
mechanisms
linking
gut
microbiota
central
nervous
system,
as
well
potential
action
for
probiotics,
are
still
not
entirely
clarified.
The
aim
this
review
was
systematically
summarize
available
knowledge
according
PRISMA
guidelines
on
molecular
probiotics
healthy
populations
subclinical
anxiety
symptoms,
depressed
patients
without
comorbid
somatic
illnesses.
standardized
mean
difference
(SMD)
95%
confidence
intervals
(CI)
calculated.
Twenty
records
were
included.
It
has
been
found
administration
linked
significant
increase
in
BDNF
levels
during
compared
placebo
(SMD
=
0.37,
CI
[0.07,
0.68],
p
0.02)
when
considering
resolution
symptoms
CRP
significantly
lower
−0.47,
[0.75,
−0.19],
0.001),
nitric
oxide
higher
0.97,
[0.58,
1.36],
<
0.0001)
probiotic-treated
placebo,
however,
only
among
co-morbidities.
There
no
differences
IL-1β,
IL-6,
IL-10,
TNF-α,
cortisol
after
between
intervention
control
groups
(all
>
0.05).
Firm
conclusions
effectiveness
their
possible
association
inflammatory
markers
population
(only
symptoms)
cannot
be
drawn.
advent
clinical
trials
examining
long-term
could
evaluate
treating
preventing
its
recurrence.
