Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 24, 2023
The
early
colonized
gut
microbiota
during
the
newborn
period
has
been
reported
to
play
important
roles
in
health
and
immunity
of
animals;
however,
whether
they
can
affect
growth
performance
suckling
lambs
is
still
unclear.
In
this
study,
a
total
84
were
assigned
into
LF-1
(top
15%),
LF-2
(medium
70%),
LF-3
(bottom
15%)
groups
according
their
average
body
weight
gain
at
30
days
age.
Fecal
samples
(LF)
as
well
feces
(MF),
vagina
(VAG),
colostrum
(COL),
teat
skin
(TEAT)
ewes,
air
sediment
(AIR)
delivery
room
collected
72
h
after
birth,
then
16S
rRNA
gene
was
sequenced
on
Illumina
MiSeq
platform.
results
showed
that
had
significant
effect
with
alpha
beta
diversity
(
p
<
0.05),
we
observed
contribution
bacteria
increased
age
(from
BW
25.35%
45
31.10%;
from
ADG
33.02%
39.79%
by
measuring
relative
effects
factors
influence
performance).
high
similar
VAG,
MF,
AIR
0.05).
With
RandomForest
machine
learning
algorithm,
detected
11,
6,
4
bacterial
taxa
genus
level
associated
,
lambs,
respectively,
correlation
analysis
Butyricicoccus,
Ruminococcus_gnavus_group,
Ruminococcaceae_Other,
Fusobacterium
could
significantly
(BW
)
conclusion,
targeting
might
be
an
alternative
strategy
improve
lambs.
The
microbiome
has
been
proven
to
be
associated
with
many
diseases
and
used
as
a
biomarker
target
in
disease
prevention
intervention.
Currently,
the
vital
role
of
pregnant
women
newborns
is
increasingly
emphasised.
In
this
review,
we
discuss
interplay
corresponding
immune
mechanism
between
mothers
their
offspring
during
perinatal
period.
We
aim
present
comprehensive
picture
microbial
transmission
potential
imprinting
before
after
delivery.
addition,
possibility
utero
colonisation
pregnancy,
which
highly
debated
recent
studies,
highlight
importance
infant
development
first
3
years
life.
This
holistic
view
infants
will
refine
our
current
understanding
pregnancy
complications
well
early
life
greatly
facilitate
microbiome-based
prenatal
diagnosis
treatment
mother-infant-related
diseases.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(2), С. 217 - 217
Опубликована: Фев. 18, 2024
Infectious
diseases
have
long
posed
a
significant
threat
to
global
health
and
require
constant
innovation
in
treatment
approaches.
However,
recent
groundbreaking
research
has
shed
light
on
previously
overlooked
player
the
pathogenesis
of
disease-the
human
microbiome.
This
review
article
addresses
intricate
relationship
between
microbiome
infectious
unravels
its
role
as
crucial
mediator
host-pathogen
interactions.
We
explore
remarkable
potential
harnessing
this
dynamic
ecosystem
develop
innovative
strategies
that
could
revolutionize
management
diseases.
By
exploring
latest
advances
emerging
trends,
aims
provide
new
perspective
combating
by
targeting
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 27, 2024
Obesity
and
chronic
low-grade
inflammation,
often
occurring
together,
significantly
contribute
to
severe
metabolic
inflammatory
conditions
like
type
2
diabetes
(T2D),
cardiovascular
disease
(CVD),
cancer.
A
key
player
is
elevated
levels
of
gut
dysbiosis-associated
lipopolysaccharide
(LPS),
which
disrupts
immune
signaling
leading
endotoxemia,
while
short-chain
fatty
acids
(SCFAs)
beneficially
regulate
these
processes
during
homeostasis.
SCFAs
not
only
safeguard
the
barrier
but
also
exert
immunomodulatory
effects
via
G
protein-coupled
receptor
binding
epigenetic
regulation.
are
emerging
as
potential
agents
counteract
dysbiosis-induced
changes,
specifically
targeting
genes
through
DNA
methylation,
histone
acetylation,
microRNAs
(miRNAs),
long
non-coding
RNAs
(lncRNAs).
To
assess
whether
can
effectively
interrupt
detrimental
cascade
obesity
this
review
aims
provide
a
comprehensive
overview
current
evidence
for
their
clinical
application.
The
emphasizes
factors
influencing
SCFA
production,
intricate
connections
between
metabolism,
system,
microbiome,
mechanisms
regulated
by
that
impact
metabolism
system.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4024 - 4024
Опубликована: Апрель 4, 2024
The
animal
gut
microbiota,
comprising
a
diverse
array
of
microorganisms,
plays
pivotal
role
in
shaping
host
health
and
physiology.
This
review
explores
the
intricate
dynamics
microbiome
animals,
focusing
on
its
composition,
function,
impact
host–microbe
interactions.
composition
intestinal
microbiota
animals
is
influenced
by
ecology,
including
factors
such
as
temperature,
pH,
oxygen
levels,
nutrient
availability,
well
genetic
makeup,
diet,
habitat,
stressors,
husbandry
practices.
Dysbiosis
can
lead
to
various
gastrointestinal
immune-related
issues
impacting
overall
productivity.
Extracellular
vesicles
(EVs),
particularly
exosomes
derived
from
play
crucial
intercellular
communication,
influencing
transporting
bioactive
molecules
across
barriers
like
brain
barriers.
Dysregulation
gut–brain
axis
has
implications
for
disorders
highlighting
potential
microbiota-derived
EVs
disease
progression.
Therapeutic
approaches
modulate
probiotics,
prebiotics,
microbial
transplants,
phage
therapy,
offer
promising
strategies
enhancing
performance.
Studies
investigating
effects
therapy
have
shown
results,
with
improving
food
safety
poultry
production
systems.
Understanding
complex
interactions
between
provides
valuable
insights
into
mechanisms
underlying
their
Further
research
this
field
essential
developing
effective
therapeutic
interventions
management
promote
well-being
animals.
Microorganisms,
Год журнала:
2023,
Номер
11(5), С. 1247 - 1247
Опубликована: Май 9, 2023
The
function
of
the
intestinal
barrier
is
partially
dependent
on
host
maturity
and
colonization
patterns
microbiome
to
which
it
exposed.
Premature
birth
stressors
neonatal
intensive
care
unit
(NICU)-related
support
(e.g.,
antibiotics,
steroids,
etc.)
can
alter
internal
environment
resulting
in
changes
barrier.
Pathogenic
microbial
proliferation
breach
immature
are
proposed
be
crucial
steps
development
diseases
such
as
necrotizing
enterocolitis.
This
article
will
review
current
literature
gut,
consequences
for
this
defense
system,
how
prematurity
influence
susceptibility
gastrointestinal
infection.
American Journal of Clinical Nutrition,
Год журнала:
2023,
Номер
117, С. S61 - S86
Опубликована: Май 1, 2023
Human
milk
contains
all
of
the
essential
nutrients
required
by
infant
within
a
complex
matrix
that
enhances
bioavailability
many
those
nutrients.
In
addition,
human
is
source
bioactive
components,
living
cells
and
microbes
facilitate
transition
to
life
outside
womb.
Our
ability
fully
appreciate
importance
this
relies
on
recognition
short-
long-term
health
benefits
and,
as
highlighted
in
previous
sections
supplement,
its
ecology
(i.e.,
interactions
among
lactating
parent
breastfed
well
context
itself).
Designing
interpreting
studies
address
complexity
depends
availability
new
tools
technologies
account
for
such
complexity.
Past
efforts
have
often
compared
formula,
which
has
provided
some
insight
into
bioactivity
milk,
whole,
or
individual
components
supplemented
with
formula.
However,
experimental
approach
cannot
capture
contributions
ecology,
interaction
between
these
matrix,
significance
itself
enhance
outcomes
interest.
This
paper
presents
approaches
explore
biological
system
functional
implications
components.
Specifically,
we
discuss
study
design
data
collection
considerations
how
emerging
analytical
technologies,
bioinformatics,
systems
biology
could
be
applied
advance
our
understanding
critical
aspect
biology.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 15, 2025
Abstract
There
are
limited
longitudinal
data
from
non-industrialized
settings
on
patterns
and
determinants
of
gut
bacterial
microbiota
development
in
early
childhood.
We
analysed
epidemiological
stool
samples
collected
60
children
followed
infancy
to
5
years
age
a
rural
tropical
district
coastal
Ecuador.
Data
were
longitudinally
wide
variety
individual,
maternal,
household
exposures.
Extracted
DNA
for
using
16S
rRNA
gene
sequencing.
Both
alpha
beta
diversity
indices
suggested
stable
profiles
towards
age.
Greater
lower
associated
with
factors
typical
poverty
including
low
incomes,
overcrowding,
greater
agricultural
animal
Consumption
unpasteurized
milk
was
consistently
indices.
Delivery
method
antibiotic
exposures
during
pregnancy
childhood
appeared
have
effects
developmental
trajectories
microbiota.
Infants
living
setting
conditions
typically
acquire
more
rapidly
diverse
microbiome
Nutrients,
Год журнала:
2022,
Номер
14(12), С. 2498 - 2498
Опубликована: Июнь 16, 2022
Type
1
diabetes
mellitus
(T1DM)
is
a
disease
marked
by
oxidative
stress,
chronic
inflammation,
and
the
presence
of
autoantibodies.
The
gut
microbiota
has
been
shown
to
be
involved
in
alleviation
stress
inflammation
as
well
strengthening
immunity,
thus
its’
possible
involvement
pathogenesis
T1DM
highlighted.
goal
present
study
analyze
information
on
relationship
between
structure
intestinal
microbiome
occurrence
T1DM.
modification
can
increase
proportion
SCFA-producing
bacteria,
which
could
turn
effective
prevention
and/or
treatment
increased
daily
intake
soluble
non-soluble
fibers,
inclusion
pro-biotics,
prebiotics,
herbs,
spices,
teas
that
are
sources
phytobiotics,
diet,
important
improving
composition
activity
metabolic
disorders.
Understanding
how
interacts
with
immune
cells
create
tolerance
enable
development
new
therapeutic
strategies
for
improve
quality
life
people
