Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(11), P. 735 - 748

Published: May 3, 2023

Language: Английский

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Microbial transmission, colonisation and succession: from pregnancy to infancy

Gut, Journal Year: 2023, Volume and Issue: 72(4), P. 772 - 786

Published: Jan. 31, 2023

The microbiome has been proven to be associated with many diseases and used as a biomarker target in disease prevention intervention. Currently, the vital role of pregnant women newborns is increasingly emphasised. In this review, we discuss interplay corresponding immune mechanism between mothers their offspring during perinatal period. We aim present comprehensive picture microbial transmission potential imprinting before after delivery. addition, possibility utero colonisation pregnancy, which highly debated recent studies, highlight importance infant development first 3 years life. This holistic view infants will refine our current understanding pregnancy complications well early life greatly facilitate microbiome-based prenatal diagnosis treatment mother-infant-related diseases.

Language: Английский

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Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

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The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4024 - 4024

Published: April 4, 2024

The animal gut microbiota, comprising a diverse array of microorganisms, plays pivotal role in shaping host health and physiology. This review explores the intricate dynamics microbiome animals, focusing on its composition, function, impact host–microbe interactions. composition intestinal microbiota animals is influenced by ecology, including factors such as temperature, pH, oxygen levels, nutrient availability, well genetic makeup, diet, habitat, stressors, husbandry practices. Dysbiosis can lead to various gastrointestinal immune-related issues impacting overall productivity. Extracellular vesicles (EVs), particularly exosomes derived from play crucial intercellular communication, influencing transporting bioactive molecules across barriers like brain barriers. Dysregulation gut–brain axis has implications for disorders highlighting potential microbiota-derived EVs disease progression. Therapeutic approaches modulate probiotics, prebiotics, microbial transplants, phage therapy, offer promising strategies enhancing performance. Studies investigating effects therapy have shown results, with improving food safety poultry production systems. Understanding complex interactions between provides valuable insights into mechanisms underlying their Further research this field essential developing effective therapeutic interventions management promote well-being animals.

Language: Английский

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The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 27, 2024

Obesity and chronic low-grade inflammation, often occurring together, significantly contribute to severe metabolic inflammatory conditions like type 2 diabetes (T2D), cardiovascular disease (CVD), cancer. A key player is elevated levels of gut dysbiosis-associated lipopolysaccharide (LPS), which disrupts immune signaling leading endotoxemia, while short-chain fatty acids (SCFAs) beneficially regulate these processes during homeostasis. SCFAs not only safeguard the barrier but also exert immunomodulatory effects via G protein-coupled receptor binding epigenetic regulation. are emerging as potential agents counteract dysbiosis-induced changes, specifically targeting genes through DNA methylation, histone acetylation, microRNAs (miRNAs), long non-coding RNAs (lncRNAs). To assess whether can effectively interrupt detrimental cascade obesity this review aims provide a comprehensive overview current evidence for their clinical application. The emphasizes factors influencing SCFA production, intricate connections between metabolism, system, microbiome, mechanisms regulated by that impact metabolism system.

Language: Английский

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Secretory IgA: Linking microbes, maternal health, and infant health through human milk

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(5), P. 650 - 659

Published: May 1, 2022

Language: Английский

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Evidence for human milk as a biological system and recommendations for study design—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 4

American Journal of Clinical Nutrition, Journal Year: 2023, Volume and Issue: 117, P. S61 - S86

Published: May 1, 2023

Human milk contains all of the essential nutrients required by infant within a complex matrix that enhances bioavailability many those nutrients. In addition, human is source bioactive components, living cells and microbes facilitate transition to life outside womb. Our ability fully appreciate importance this relies on recognition short- long-term health benefits and, as highlighted in previous sections supplement, its ecology (i.e., interactions among lactating parent breastfed well context itself). Designing interpreting studies address complexity depends availability new tools technologies account for such complexity. Past efforts have often compared formula, which has provided some insight into bioactivity milk, whole, or individual components supplemented with formula. However, experimental approach cannot capture contributions ecology, interaction between these matrix, significance itself enhance outcomes interest. This paper presents approaches explore biological system functional implications components. Specifically, we discuss study design data collection considerations how emerging analytical technologies, bioinformatics, systems biology could be applied advance our understanding critical aspect biology.

Language: Английский

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Development of the Neonatal Intestinal Barrier, Microbiome, and Susceptibility to NEC

Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1247 - 1247

Published: May 9, 2023

The function of the intestinal barrier is partially dependent on host maturity and colonization patterns microbiome to which it exposed. Premature birth stressors neonatal intensive care unit (NICU)-related support (e.g., antibiotics, steroids, etc.) can alter internal environment resulting in changes barrier. Pathogenic microbial proliferation breach immature are proposed be crucial steps development diseases such as necrotizing enterocolitis. This article will review current literature gut, consequences for this defense system, how prematurity influence susceptibility gastrointestinal infection.

Language: Английский

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The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

Nutrients, Journal Year: 2022, Volume and Issue: 14(12), P. 2498 - 2498

Published: June 16, 2022

Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in alleviation stress inflammation as well strengthening immunity, thus its’ possible involvement pathogenesis T1DM highlighted. goal present study analyze information on relationship between structure intestinal microbiome occurrence T1DM. modification can increase proportion SCFA-producing bacteria, which could turn effective prevention and/or treatment increased daily intake soluble non-soluble fibers, inclusion pro-biotics, prebiotics, herbs, spices, teas that are sources phytobiotics, diet, important improving composition activity metabolic disorders. Understanding how interacts with immune cells create tolerance enable development new therapeutic strategies for improve quality life people

Language: Английский

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Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials

Journal of Global Health, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 13, 2024

Microbes in the human body are determinants of life-long health and disease. Microbiome acquisition starts utero matures during early childhood through breastfeeding. However, maternal gut dysbiosis affects maternal-offspring microbiome interplay. Lines evidence on dysbiosis-targeted interventions their effect inconsistent inconclusive. Therefore, this study summarised studies to identify most common microbiota-targeted intervention pregnancy lactation comprehensively evaluate its effects offspring health.

Language: Английский

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