Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review

Molecules, Год журнала: 2022, Номер 27(11), С. 3400 - 3400

Опубликована: Май 25, 2022

The demand of foods with high antioxidant capacity have increased and research on these continues to grow. This review is focused chlorogenic acids (CGAs) from green coffee, which the most abundant source. main CGA in coffee 5-O-caffeoylquinic acid (5-CQA). Coffee extracts are currently widely used source enhance activity foods. Due solubility CGAs, their extraction mainly performed organic solvents. CGAs been associated health benefits, such as antioxidant, antiviral, antibacterial, anticancer, anti-inflammatory activity, others that reduce risk cardiovascular diseases, type 2 diabetes, Alzheimer’s disease. However, biological activities depend stability sensitive pH, temperature, light. 5-CQA attributed reducing proinflammatory cytokines. can negatively affect colon microbiota. An increase anthocyanins was observed when were added different food matrices dairy products, drinks, chocolate, bakery products. fortification has potential improve functionality

Язык: Английский

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Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Molecules, Год журнала: 2020, Номер 25(19), С. 4553 - 4553

Опубликована: Окт. 5, 2020

Tea and coffee are consumed worldwide epidemiological clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) chlorogenic acid (CGA) the major components of green tea polyphenols polyphenols, respectively, believed to be responsible for most these Although a large number cell-based animal experiments provided convincing evidence support effects tea, coffee, EGCG, CGA, human still controversial some suggested even an increased risk certain types cancers such as esophageal gynecological with consumption bladder lung consumption. The reason inconsistent results may been arisen from various confounding factors. Cell-based proposed several mechanisms whereby EGCG CGA exert These appear share common mechanisms, among which one related reactive oxygen species is perhaps attractive. Meanwhile, also different target molecules might explain site-specific differences found in studies. Further will necessary clarify what mechanism cause between coffee.

Язык: Английский

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Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway

Oncology Reports, Год журнала: 2020, Номер 45(2), С. 717 - 727

Опубликована: Дек. 9, 2020

Breast cancer which is the most common type of diagnosed among women worldwide possesses metastatic potential, multi‑drug resistance, and high mortality. The NF‑κB signaling pathway has been revealed to be abnormally activated in breast cells closely associated with metastasis poor prognosis. In present study, it was reported that chlorogenic acid (CGA), a potent inhibitor derived from coffee, exerted antitumor activity cancer. MTT colony formation assays were conducted CGA inhibited viability proliferation cells. Additionally, significantly induced apoptosis suppressed migration invasion Notably, immunofluorescence analysis confirmed could efficiently suppress nuclear transcription p65. addition, results western blotting demonstrated markedly impaired EMT pathways. effect evaluated subcutaneous tumor mouse model 4T1 cells, retarded growth prolonged survival rate tumor‑bearing mice. pulmonary by enhancing proportion CD4+ CD8+ T spleens mice, indicated an improvement immunity. conclusion, study improved immunity, exerting anti‑metastatic effects impairing NF‑κB/EMT pathway, suggesting may serve as potential candidate for therapy

Язык: Английский

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Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Nutrients, Год журнала: 2020, Номер 13(1), С. 88 - 88

Опубликована: Дек. 29, 2020

Coffee is one of the most popular beverages consumed worldwide. Roasted coffee a complex mixture thousands bioactive compounds, and some them have numerous potential health-promoting properties that been extensively studied in cardiovascular central nervous systems, with relatively much less attention given to other body such as gastrointestinal tract its particular connection brain, known brain-gut axis. This narrative review provides an overview effect brew; by-products; components on mucosa (mainly involved permeability, secretion, proliferation), neural non-neural gut wall responsible for motor function, Despite vitro, vivo, epidemiological studies having shown may exert multiple effects digestive tract, including antioxidant, anti-inflammatory, antiproliferative mucosa, pro-motility external muscle layers, still surprisingly unknown. Further are needed understand mechanisms action certain transfer this knowledge industry develop functional foods improve axis health.

Язык: Английский

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Post‐diagnosis dietary factors, supplement use and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

International Journal of Cancer, Год журнала: 2024, Номер 155(3), С. 445 - 470

Опубликована: Май 1, 2024

Abstract The role of diet in colorectal cancer prognosis is not well understood and specific lifestyle recommendations are lacking. We searched for randomised controlled trials (RCTs) longitudinal observational studies on post‐diagnosis dietary factors, supplement use survival outcomes PubMed Embase from inception until 28th February 2022. Random‐effects dose–response meta‐analyses were conducted when at least three had sufficient information. evidence was interpreted graded by the CUP Global independent Expert Committee Cancer Survivorship Panel. Five RCTs 35 included (30,242 cases, over 8700 all‐cause 2100 deaths, 3700 progression, recurrence, or disease‐free events). Meta‐analyses, including 3–10 each, for: whole grains, nuts/peanuts, red processed meat, dairy products, sugary drinks, artificially sweetened beverages, coffee, alcohol, glycaemic load/index, insulin marine omega‐3 polyunsaturated fatty acids, supplemental calcium, circulating 25‐hydroxyvitamin D (25[OH]D) mortality; 25(OH)D cancer‐specific recurrence/disease‐free survival. overall as ‘limited’. inverse associations between healthy and/or patterns (including diets that comprised plant‐based foods), total, caffeinated, decaffeinated coffee mortality positive unhealthy patterns, drinks provided ‘limited—suggestive’ evidence. All other exposure‐outcome ‘limited—no conclusion’ Additional, well‐conducted cohort carefully designed needed to develop survivors.

Язык: Английский

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Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection

Frontiers in Microbiology, Год журнала: 2020, Номер 11

Опубликована: Фев. 10, 2020

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus (SFTSV), which a novel bunyavirus. SFTSV was first isolated from patients who presented fever, thrombocytopenia, leukocytopenia, and multiorgan dysfunction in China. Subsequently, it found to be widely distributed Southeast Asia (Korea, Japan, Vietnam). can transmitted not only ticks but also domestic animals, companion humans. Because the case fatality rate of high (6%–30%), development specific effective treatment for required. Studies potential antiviral drugs SFTS-specific therapy have been conducted on existing or newly discovered agents vitro vivo, ribavirin favipiravir being most promising candidates. While animal experiments retrospective studies demonstrated limited efficacy ribavirin, speculated that would viral load 5-fold. Although further research necessary develop therapy, considerable progress has achieved this area. Here we summarize discuss recent advances against SFTSV.

Язык: Английский

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Caffeine and its main targets of colorectal cancer

World Journal of Gastrointestinal Oncology, Год журнала: 2020, Номер 12(2), С. 149 - 172

Опубликована: Фев. 15, 2020

Caffeine is a purine alkaloid and widely consumed in coffee, soda, tea, chocolate energy drinks. To date, growing number of studies have indicated that caffeine associated with many diseases including colorectal cancer. exerts its biological activity through binding to adenosine receptors, inhibiting phosphodiesterases, sensitizing calcium channels, antagonizing gamma-aminobutyric acid receptors stimulating adrenal hormones. Some can interact signaling pathways such as transforming growth factor β, phosphoinositide-3-kinase/AKT/mammalian target rapamycin mitogen-activated protein kinase which play an important role cancer pathogenesis, metastasis prognosis. Moreover, act general antioxidant protects cells from oxidative stress also regulatory the cell cycle modulates DNA repair system. Additionally, for intestinal homeostasis, interaction cytokines, modulate immune system mediating effects on T lymphocytes, B natural killer macrophages. Furthermore, not only directly inhibit species gut microbiome, Escherichia coli Candida albicans but indirectly exert inhibition by increasing other antimicrobial drugs. This review summarizes association between being currently studied.

Язык: Английский

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In Vitro Bioaccessibility and Antioxidant Activity of Coffee Silverskin Polyphenolic Extract and Characterization of Bioactive Compounds Using UHPLC-Q-Orbitrap HRMS

Molecules, Год журнала: 2020, Номер 25(9), С. 2132 - 2132

Опубликована: Май 2, 2020

Coffee silverskin (CS), the main by-product in coffee industry, contains a vast number of human health-related compounds, which may justify its exploitation as functional food ingredient. This study aimed to provide comprehensive analysis polyphenolic and alkaloid profile through UHPLC-Q-Orbitrap HRMS analysis. The bioaccessibility total phenolic compounds changes antioxidant activity during an vitro gastrointestinal digestion were also evaluated spectrophotometric tests (TPC by Folin-Ciocalteu, ABTS, DPPH, FRAP), elucidate their efficacy for future applications nutraceutical industry. Caffeoylquinic feruloylquinic acids most representative polyphenols, with mean concentration 5.93 4.25 mg/g, respectively. Results showed high content caffeine analyzed CS extracts, value 31.2 meaning two-fold increase when compared brews. Our findings highlighted that both polyphenols significantly increased each stage. In addition, colon stage might constitute biological site action these compounds. These results suggest vivo, dietary from be metabolized colonic microflora, generating metabolites greater activity, increasing well-known beneficial effects.

Язык: Английский

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Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease

Molecules, Год журнала: 2023, Номер 28(18), С. 6440 - 6440

Опубликована: Сен. 5, 2023

Cardiovascular diseases (CVDs) are considered the predominant cause of death globally. An abnormal increase in biomarkers oxidative stress and inflammation consistently linked with development even progression metabolic diseases, including enhanced CVD risk. Coffee is one most consumed beverages world, while reviewed evidence regarding its capacity to modulate remains limited. The current study made use prominent electronic databases, PubMed, Google Scholar, Scopus retrieve information from randomized controlled trials reporting on any association between coffee consumption modulation healthy individuals or those at increased risk developing CVD. In fact, summarized indicates that consumption, mainly due abundant antioxidant properties, can reduce inflammation, which be essential alleviating individuals. However, more suggests regular/prolonged long term (>4 weeks) appeared beneficial comparison short-term intake (<4 weeks). These positive effects also observed already presenting risk, although such very analysis data highlights importance understanding how strengthening intracellular antioxidants alleviate pathological features within general population. Also covered review metabolism bioavailability profile coffee, especially caffeine as major bioactive compounds.

Язык: Английский

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Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines

Genetics and Molecular Biology, Год журнала: 2020, Номер 43(3)

Опубликована: Янв. 1, 2020

Dietary phenolic compounds such as caffeic and chlorogenic acid exert an antiproliferative effect modulate the gene-specific DNA methylation status in human breast tumor cells, but it remains unclear whether they interfere with global leukemia cells. We examined (1-250 µM) antitumor action promyelocytic cells (HL-60) acute T-cell (Jurkat). Caffeic did not reduce cell viability two lines, assessed using neutral red uptake MTT assays. These acids (1-100 μM) neither induced damage (comet assay) nor increased micronuclei frequency (micronucleus HL-60 Jurkat indicating that were genotoxic or mutagenic. Analysis of levels a 5-mC ELISA kit revealed at non-cytotoxic concentration (100 hypomethylation suggesting exerts cell-specific effect. change methylation. As other compounds, probably modulates by targeting methyltransferases. The hypomethylating can be beneficial against hematological malignances whose pathogenic processes involve impairment

Язык: Английский

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