Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Molecules, Год журнала: 2020, Номер 25(19), С. 4553 - 4553

Опубликована: Окт. 5, 2020

Tea and coffee are consumed worldwide epidemiological clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) chlorogenic acid (CGA) the major components of green tea polyphenols polyphenols, respectively, believed to be responsible for most these Although a large number cell-based animal experiments provided convincing evidence support effects tea, coffee, EGCG, CGA, human still controversial some suggested even an increased risk certain types cancers such as esophageal gynecological with consumption bladder lung consumption. The reason inconsistent results may been arisen from various confounding factors. Cell-based proposed several mechanisms whereby EGCG CGA exert These appear share common mechanisms, among which one related reactive oxygen species is perhaps attractive. Meanwhile, also different target molecules might explain site-specific differences found in studies. Further will necessary clarify what mechanism cause between coffee.

Язык: Английский

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Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives

Phytotherapy Research, Год журнала: 2021, Номер 35(8), С. 4194 - 4214

Опубликована: Март 22, 2021

The global incidence of cancer and cancer‐related mortality is expected to rise in recent years despite advancements diagnosis therapeutics. Increasing evidences decrypting molecular mechanisms underlying progression have commanded the tremendous development synthetic anticancer drugs. With limitations current conventional therapeutic approaches, non‐nutritive dietary phytochemicals emerged as potent modulators apoptosis autophagy associated key signaling pathways various cells. dynamic regulation by are identified promising candidates with minimal cytotoxicity enhanced biological activity. Dietary their analogs exhibited potency modulation several cells individuals or combination pre‐existing FDA (Food Drug Administration) approved In generation medical science, developing precision personalized medicine consumption food supplements will hold high prevalence Hence understating impact on human health mechanism thrive a new horizon Hence, this review has emphasized role apoptotic/autophagy modulating therapy, preclinical clinical applications future direction nano‐formulation for better efficacy.

Язык: Английский

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Caffeine and Its Antioxidant Properties—It Is All about Dose and Source

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(21), С. 13074 - 13074

Опубликована: Окт. 28, 2022

Caffeine is the most frequently used substance with a central nervous system stimulant effect, but its consumption often due to intake of foods and drinks that contain it (coffee, tea, chocolate, food supplements plant extracts Guarana, Mate herba, Cola nuts). Due innocuity, caffeine safe xanthine alkaloid for human in wide range doses, being stimulating lipolytic diuresis-enhancing properties, also as permitted ergogenic compound athletes. In addition mechanisms explain effects on targeted organ, there are many proposed by which this would have antioxidant effects. As such, prevents occurrence/progression certain neurodegenerative diseases well other medical conditions associated increased levels reactive oxygen or nitrogen species. However, studies assessed beneficial pure caffeine. The question, therefore, arises whether daily from drink has similar benefits, considering high content, substances could interfere action, either potentiating decreasing capacity. Natural sources combine polyphenols (phenol-carboxylic acids, catechins) known effects; however, dietary sugars artificial sweeteners can significantly reduce oxidative stress. objective review clarify modulating stress assess these source dose administered.

Язык: Английский

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Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1067 - 1067

Опубликована: Июль 27, 2023

Caffeine is a naturally occurring alkaloid found in various plants. It acts as stimulant, antioxidant, anti-inflammatory, and even an aid pain management, several over-the-counter medications. This derived bioactive compound the best-known ingredient coffee other beverages, such tea, soft drinks, energy widely consumed worldwide. Therefore, it extremely important to research effects of this substance on human body. With mind, caffeine its derivatives have been extensively studied evaluate ability prevent diseases exert anti-aging neuroprotective effects. review intended provide overview caffeine’s cancer cardiovascular, immunological, inflammatory, neurological diseases, among others. The heavily researched area sports will also be discussed. Finally, recent advances development novel nanocarrier-based formulations, enhance bioavailability beneficial

Язык: Английский

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Chemical diversity of dietary phytochemicals and their mode of chemoprevention

Biotechnology Reports, Год журнала: 2021, Номер 30, С. e00633 - e00633

Опубликована: Май 18, 2021

Despite the advancement in prognosis, diagnosis and treatment, cancer has emerged as second leading cause of disease-associated death across globe. With remarkable application synthetic drugs therapy onset therapy-associated adverse effects, dietary phytochemicals have been materialized potent anti-cancer owing to their antioxidant, apoptosis autophagy modulating activities. dynamic regulation association with cell cycle regulation, inhibition cellular proliferation, invasion migration, pharmacophores. Dietary or analogous individual drug candidates combination FDA approved chemotherapeutic exhibited efficacy. therapeutics, hold high prevalence for use precision personalized medicine replace conventional drugs. Hence, keeping these perspectives mind, this review focuses on diversity molecular mechanism action several subtypes tumor entities. Understanding possible key players involved, will thrive a new horizon therapy.

Язык: Английский

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Therapeutic opportunities in colon cancer: Focus on phosphodiesterase inhibitors

Life Sciences, Год журнала: 2019, Номер 230, С. 150 - 161

Опубликована: Май 21, 2019

Язык: Английский

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Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids

Frontiers in Pharmacology, Год журнала: 2021, Номер 12

Опубликована: Дек. 16, 2021

Cancer is a complex multifactorial disease that results from alterations in many physiological and biochemical functions. Over the last few decades, it has become clear cancer cells can acquire multidrug resistance to conventional anticancer drugs, resulting tumor relapse. Thus, there continuous need discover new effective drugs. Natural products plants have served as primary source of drugs continue provide plant-derived The present review describes plant-based alkaloids, which been reported active or potentially treatment within past 4 years (2017–2020), both preclinical research and/or clinical trials. In addition, recent insights into possible molecular mechanism action alkaloid prodrugs naturally are also highlighted.

Язык: Английский

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Inosine, gut microbiota, and cancer immunometabolism

AJP Endocrinology and Metabolism, Год журнала: 2022, Номер 324(1), С. E1 - E8

Опубликована: Ноя. 23, 2022

This article briefly reviews cancer immunity and the role of gut microbiota in carcinogenesis, followed by an understanding mechanisms which inosine is involved immunometabolism. The immune system plays a paradoxical treatment. Antitumor depends on T-cell priming against tumor antigens, whereas inflammatory mediators trigger protumor signaling microenvironment. Studies link microbiome with metabolism immunity-two main factors implicated carcinogenesis. Gut has been shown to affect both antitumor signaling. There mounting evidence that human can play immunotherapeutic effects, response resistance. Inosine-5'-monophosphate dehydrogenase (IMPDH) highly conservative enzyme widely expressed mammals. Cell pathways use molecular inosine, crucial secondary metabolite purine messenger. Recent research identified as critical regulator checkpoint inhibition (ICI) therapeutic various types. Some bacterial species were found produce or its hypoxanthine induce T-helper 1 differentiation effector functions via inosine-A2AR-cAMP-PKA pathway upon ICI therapy. Also, acts substitute carbon source for glucose-restricted environments, i.e., microenvironment, assisting proliferation while enhancing sensitivity ICI, reinforcing notion might contribute immunity. potent agonist adenosine receptor, A2AR, A2AR responses immunity, making inosine-A2AR blockage candidate Further required investigate immunometabolism

Язык: Английский

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Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Опубликована: Май 17, 2023

Caffeine is a naturally occurring alkaloid found in various plants. It acts as stimulant, antioxidant, anti-inflammatory and even an aid pain management, several over-the-counter medications. This derived bioactive compound the best-known ingredient coffee other beverages, such tea, soft drinks, energy most widely consumed substance worldwide. Therefore, it extremely important to research effects of this on human body. With mind, caffeine its derivatives have been extensively studied evaluate ability prevent diseases exert anti-aging neuroprotective effects. review intended provide overview cancer, cardiovascular, immunological, inflammatory, neurological diseases, among others. The heavily researched area sports will also be discussed. Finally, recent advances development novel formulations, form dietary supplements nanocarriers, enhance bioavailability beneficial On hand, may contribute elevated blood pressure, anemia, migraine.

Язык: Английский

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Elderly Patients with Tuberculosis Combined with Diabetes Mellitus: A Comprehensive Analysis of Lymphocyte Subpopulation Dynamics, Clinical Features, Drug Resistance and Disease Regression

International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 1271 - 1282

Опубликована: Март 1, 2025

The aim of this study was to evaluate lymphocyte subsets and clinical outcomes in patients with pulmonary tuberculosis (PTB) combined type 2 diabetes mellitus (T2DM). Between January 2022 March 2024, 320 aged > 60 years were included, 95 whom had comorbid DM. Lymphocyte (T-lymphocytes, B-lymphocytes, natural killer cells, NK) assessed both groups using fluorescence-associated cell sorting. Clinical characteristics, drug resistance, regression compared PTB DM versus alone. correlation between subsets-related indices the above characteristics analyzed. Compared alone, a higher positive rate (81.05% vs 62.67%, P = 0.001), prolonged course antituberculosis treatment (298 [244, 339] days 223 [179, 254], < 0.001) lower cured (64.21% 75.56%, 0.039). only, T-lymphocytes CD4+ (P 0.001, 0.006) NK cells 0.001). In DM, treatment-prolonged drug-resistant showed reduced cells. slightly elevated patients, although there no significant difference 0.082). homeostasis is altered making them more susceptible severe manifestations therapeutic outcomes. Notably, have been identified as key regulatory impact on resistance. This provides new ideas methods for individualized elderly, which can help optimize plan improve outcome quality life patients.

Язык: Английский

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