International Journal of Biological Macromolecules, Год журнала: 2020, Номер 167, С. 1308 - 1318
Опубликована: Ноя. 14, 2020
Язык: Английский
Food Chemistry X, Год журнала: 2022, Номер 15, С. 100414 - 100414
Опубликована: Авг. 8, 2022
Fungi, as the unique natural resource, are rich in polysaccharides, proteins, fats, vitamins, and other components. Therefore, they have good medical nutritional values. Polysaccharides considered one of most important bioactive components fungi. Increasing researches confirmed that fungal polysaccharides various biological activities, such antioxidant, immunomodulatory, anti-tumor, hepatoprotective, anti-aging, anti-inflammatory, radioprotective activities. Consequently, research progresses future prospects must be systematically reviewed to promote their better understanding. This paper extraction, purification, structure, activity, underlying molecular mechanisms polysaccharides. Moreover, structure–activity relationships were emphasized discussed. review can provide scientific basis for industrial utilization
Язык: Английский
Процитировано
89
Antioxidants, Год журнала: 2022, Номер 11(12), С. 2491 - 2491
Опубликована: Дек. 19, 2022
Many chronic diseases such as Alzheimer's disease, diabetes, and cardiovascular are closely related to in vivo oxidative stress caused by excessive reactive oxygen species (ROS). Natural polysaccharides, a kind of biomacromolecule with good biocompatibility, have been widely used biomedical medicinal applications due their superior antioxidant properties. In this review, scientometric analysis the highly cited papers Web Science (WOS) database finds that activity is most studied popular among pharmacological effects natural polysaccharides. The mechanisms polysaccharides mainly contain regulation signal transduction pathways, activation enzymes, scavenging free radicals. We continuously discuss activities derivatives. At same time, we summarize field pharmaceutics/drug delivery, tissue engineering, antimicrobial food additives/packaging materials. Overall, review provides up-to-date information for further development application activities.
Язык: Английский
Процитировано
76
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132391 - 132391
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
50
The Science of The Total Environment, Год журнала: 2023, Номер 877, С. 162910 - 162910
Опубликована: Март 17, 2023
Язык: Английский
Процитировано
45
Nutrients, Год журнала: 2023, Номер 15(8), С. 1913 - 1913
Опубликована: Апрель 15, 2023
The last century has seen an increase in our life expectancy. As a result, various age-related diseases, such as neurodegenerative diseases (NDs), have emerged, representing new challenges to society. Oxidative stress (OS), condition of redox imbalance resulting from excessive production reactive oxygen species, represents common feature that characterizes the brains elderly people, thus contributing NDs. Consequently, antioxidant supplementation or dietary intake antioxidant-containing foods could represent effective preventive and therapeutic intervention maintain integrity survival neurons counteract pathologies associated with aging. Food contains numerous bioactive molecules beneficial actions for human health. To this purpose, wide range edible mushrooms been reported produce different compounds phenolics, flavonoids, polysaccharides, vitamins, carotenoids, ergothioneine, others, which might be used enhance defenses and, consequently, prevention neurological diseases. In review, we summarized role oxidative NDs, focusing on current knowledge present mushrooms, highlighting their potential preserve healthy aging by counteracting age-associated
Язык: Английский
Процитировано
42
Frontiers in Nutrition, Год журнала: 2022, Номер 9
Опубликована: Янв. 28, 2022
Proteomics and intestinal flora were used to determine the mechanism of immune modulatory effects Flammulina velutipes polysaccharide on immunosuppressed mice. The results showed that compared with model group, F. could increase thymus spleen indices improve tissue structure in mice; IL-2 IL-4 contents significantly increased IL-6 TNF-α decreased; serum acid phosphatase (ACP), lactate dehydrogenase (LDH) total antioxidant capacity (T-AOC) activities (P < 0.05); liver, superoxide dismutase (SOD) catalase (CAT) 0.001), while malondialdehyde (MDA) content was decreased 0.001). discovered polysaccharides may exert by participating signaling pathways such as diseases, transport catabolism, phagosomes influenza A, regulating immune-related proteins Transferrin receptor protein 1 (TFRC) Radical S-adenosyl methionine domain-containing 2 (RSAD2), etc. Gut microbial studies abundance structure. Compared short-chain fatty acids (SCFAs) relative SCFA-producers Bacteroides Alloprevotella administration Lachnospiraceae_NK4A136_group f_Lachnospiraceae_Unclassified abundance. Thus, play an immunomodulatory role environment improving balance flora.
Язык: Английский
Процитировано
45
Polymers, Год журнала: 2022, Номер 14(20), С. 4454 - 4454
Опубликована: Окт. 21, 2022
Edible fungi, commonly known as mushrooms, are precious medicinal and edible homologous gifts from nature to us. Because of their distinctive flavor exceptional nutritional value, they have been a frequent visitor people’s dining tables become hot star in the healthcare, pharmaceutical, cosmetics industries. fungal polysaccharides (EFPs) an essential nutrient for fungi exert bioactivity. They attracted much attention because antioxidant, immunomodulatory, antitumor, hypoglycemic, hypolipidemic bioactivities. As result, EFPs demonstrated outstanding potential over past few decades various disciplines, including molecular biology, immunology, biotechnology, pharmaceutical chemistry. However, complexity significant impact mushroom variety extraction techniques on bioactivities prevents complete investigation biological features. Therefore, authors this paper thoroughly reviewed comparison different methods advantages disadvantages. In addition, weight, monosaccharide composition, glycosidic bond type backbone structure described detail. Moreover, vitro vivo extracted by regulatory mechanisms summarized. These provide valuable reference improving process production development field.
Язык: Английский
Процитировано
40
Deleted Journal, Год журнала: 2024, Номер 1(1), С. 100004 - 100004
Опубликована: Янв. 30, 2024
Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency. As a highly active substance nature, natural polysaccharides been reported recent years various cosmetic activities such as moisturizing, whitening, anti-aging repairing skin, are becoming hot research topic industry. At present, mechanism of polysaccharide exerting activity has widely studied, but relationship between polysaccharide's chemical structure not effectively analyzed, which leads limitation development. In this review, skin repair was introduced. The potential summarized by analyzing influence physical properties polysaccharides, extraction method, molecular weight, monosaccharide composition, functional group structural modification, etc., laid foundation for analysis improved its value.
Язык: Английский
Процитировано
15
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139660 - 139660
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2020, Номер 167, С. 528 - 538
Опубликована: Дек. 2, 2020
Язык: Английский
Процитировано
65