IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Interventional
neuroimaging
represents
a
transformative
approach
to
understanding,
diagnosing,
and
treating
neurodegenerative
diseases.
This
chapter
explores
the
foundational
principles
of
bio-imaging
about
conditions
such
as
Alzheimer’s
Disease,
Parkinson’s
Huntington’s
Disease.
It
highlights
role
advanced
imaging
modalities,
including
structural,
functional,
molecular,
hybrid
techniques,
in
detecting
disease-specific
biomarkers,
monitoring
progression,
guiding
therapeutic
strategies.
The
integration
cutting-edge
technologies
like
artificial
intelligence,
ultrahigh-field
imaging,
multimodal
approaches
is
discussed
pivotal
factor
shaping
future
neuroimaging.
Furthermore,
delves
into
applications
for
early
diagnosis,
disease
monitoring,
personalized
medicine.
Emphasizing
current
advancements
directions,
this
underscores
critical
revolutionizing
neuroscience
clinical
practice.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
146, С. 112610 - 112610
Опубликована: Янв. 4, 2022
Neurodegenerative
disorders
(NDs)
including
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis,
Huntington's
and
multiple
sclerosis
have
various
disease-specific
causal
factors
pathological
features.
A
very
common
characteristic
of
NDs
is
oxidative
stress
(OS),
which
takes
place
due
to
the
elevated
generation
reactive
oxygen
species
during
progression
NDs.
Furthermore,
condition
an
increased
level
protein
aggregates
can
further
lead
chronic
inflammation
because
microglial
activation.
Carotenoids
(CTs)
are
naturally
occurring
pigments
that
play
a
significant
role
in
averting
brain
disorders.
More
than
750
CTs
present
nature,
they
widely
available
plants,
microorganisms,
animals.
accountable
for
red,
yellow,
orange
several
animals
these
colors
usually
indicate
types
CTs.
exert
bioactive
properties
its
structure,
anti-inflammatory
antioxidant
properties.
Due
protective
CTs,
levels
human
body
been
markedly
linked
with
prevention
treatment
diseases
In
this
review,
we
summarized
relationship
between
OS,
neuroinflammation,
addition,
also
particularly
focused
on
antioxidants
management
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(2), С. 616 - 616
Опубликована: Янв. 6, 2022
Dementia
is
a
neurodegenerative
condition
that
considered
major
factor
contributing
to
cognitive
decline
reduces
independent
function.
Pathophysiological
pathways
are
not
well
defined
for
diseases
such
as
dementia;
however,
published
evidence
has
shown
the
role
of
numerous
inflammatory
processes
in
brain
toward
their
pathology.
Microglia
central
nervous
system
(CNS)
principal
components
brain’s
immune
defence
and
can
detect
harmful
or
external
pathogens.
When
stimulated,
cells
trigger
neuroinflammatory
responses
by
releasing
proinflammatory
chemokines,
cytokines,
reactive
oxygen
species,
nitrogen
species
order
preserve
cell’s
microenvironment.
These
markers
include
cytokines
IL-1,
IL-6,
TNFα
chemokines
CCR3
CCL2
CCR5.
Microglial
may
produce
prolonged
response
that,
some
circumstances,
indicated
promotion
diseases.
The
present
review
focused
on
involvement
microglial
cell
activation
throughout
conditions
link
between
dementia.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
149, С. 112877 - 112877
Опубликована: Март 31, 2022
Emodin
is
an
anthraquinone
derivative
found
in
the
roots
and
bark
of
a
variety
plants,
molds,
lichens.
has
been
used
as
traditional
medication
for
more
than
2000
years
still
common
numerous
herbal
drugs.
plentiful
three
plant
families,
including
Polygonaceae
(Rheum,
Rumex,
Polygonum
spp.),
Fabaceae
(Cassia
Rhamnaceae
(Rhamnus,
Frangula,
Ventilago
spp.).
Emerging
experimental
evidences
indicate
that
emodin
confers
wide
range
pharmacological
activities;
special
focus
was
implemented
toward
neurodegenerative
diseases,
Alzheimer's
disease,
Parkinson's
cerebral
ischemia,
anxiety
depression,
schizophrenia,
chronic
hyperglycemic
peripheral
neuropathy,
etc.
Numerous
preclinical
were
established
support
neuroprotection
emodin.
However,
this
review
highlighted
role
potent
neurotherapeutic
agent;
therefore,
its
evidence-based
functionality
on
neurological
disorders
(NDs).
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(4), С. 1332 - 1355
Опубликована: Янв. 1, 2024
Polyphenolic
compounds
have
shown
promising
neuroprotective
properties,
making
them
a
valuable
resource
for
identifying
prospective
drug
candidates
to
treat
several
neurological
disorders
(NDs).Numerous
studies
reported
that
polyphenols
can
disrupt
the
nuclear
factor
kappa
B(NF-κB)
pathway
by
inhibiting
phosphorylation
or
ubiquitination
of
signaling
molecules,
which
further
prevents
degradation
IκB.Additionally,
they
prevent
NF-κB
translocation
nucleus
and
pro-inflammatory
cytokine
production.Polyphenols
such
as
curcumin,
resveratrol,
pterostilbene
had
significant
inhibitory
effects
on
NF-κB,
treating
NDs.Recent
experimental
findings
suggest
possess
wide
range
pharmacological
properties.Notably,
much
attention
has
been
directed
towards
their
potential
therapeutic
in
NDs
Alzheimer's
disease
(AD),
Parkinson's
(PD),
cerebral
ischemia,
anxiety,
depression,
autism,
spinal
cord
injury
(SCI).Much
preclinical
data
supporting
neurotherapeutic
benefits
developed.Nevertheless,
this
study
described
significance
agents,
specifically
emphasizing
impact
pathway.This
article
offers
comprehensive
analysis
involvement
NDs,
including
both
clinical
perspectives.
Molecules,
Год журнала:
2021,
Номер
26(21), С. 6531 - 6531
Опубликована: Окт. 29, 2021
Huperzine
A
(HupA),
an
alkaloid
found
in
the
club
moss
Huperzia
serrata,
has
been
used
for
centuries
Chinese
folk
medicine
to
treat
dementia.
The
effects
of
this
have
attributed
its
ability
inhibit
cholinergic
enzyme
acetylcholinesterase
(AChE),
acting
as
inhibitor
(AChEI).
biological
functions
HupA
studied
both
vitro
and
vivo,
role
neuroprotection
appears
be
a
good
therapeutic
candidate
Alzheimer´s
disease
(AD).
Here,
we
summarize
neuroprotective
on
AD,
with
emphasis
interactions
different
molecular
signaling
avenues,
such
Wnt
signaling,
pre-
post-synaptic
region
mechanisms
(synaptotagmin,
neuroligins),
amyloid
precursor
protein
(APP)
processing,
amyloid-β
peptide
(Aβ)
accumulation,
mitochondrial
protection.
Our
goal
is
provide
integrated
overview
through
which
affects
AD.
Molecules,
Год журнала:
2022,
Номер
27(9), С. 2834 - 2834
Опубликована: Апрель 29, 2022
Parkinson's
disease
(PD)
and
Alzheimer's
(AD)
are
neurodegenerative
disorders
that
have
emerged
as
among
the
serious
health
problems
of
21st
century.
The
medications
currently
available
to
treat
AD
PD
limited
efficacy
associated
with
side
effects.
Natural
products
one
most
vital
conservative
sources
medicines
for
treating
neurological
problems.
Karanjin
is
a
furanoflavonoid,
isolated
mainly
from
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 4, 2022
Alzheimer’s
disease
(AD)
is
a
chronic,
complex
neurodegenerative
disorder
mainly
characterized
by
the
irreversible
loss
of
memory
and
cognitive
functions.
Different
hypotheses
have
been
proposed
thus
far
to
explain
etiology
this
devastating
disorder,
including
those
centered
on
Amyloid-β
(Aβ)
peptide
aggregation,
Tau
hyperphosphorylation,
neuroinflammation
oxidative
stress.
Nonetheless,
therapeutic
strategies
conceived
treat
AD
neurodegeneration
proven
unsuccessful,
probably
due
use
single-target
drugs
unable
arrest
progressive
deterioration
brain
For
reason,
theoretical
description
has
recently
switched
from
over-emphasizing
single
deleterious
process
considering
as
result
different
pathogenic
mechanisms
their
interplay.
Moreover,
much
relevance
conferred
several
comorbidities
inducing
insulin
resistance
energy
hypometabolism,
diabetes
obesity.
As
consequence,
interest
currently
accorded
in
treatment
multi-target
approach
interfering
with
pathways
at
same
time,
life-style
interventions
aimed
preventing
modifiable
risk-factors
strictly
associated
aging.
In
context,
phytochemical
compounds
are
emerging
an
enormous
source
draw
search
for
agents
completing
or
assisting
traditional
pharmacological
medicine.
Intriguingly,
many
plant-derived
efficacy
counteracting
processes
such
Aβ
neuroinflammation,
stress
resistance.
Many
also
overcome
limitations
some
promising
phytochemicals
related
poor
pharmacokinetic
profiles,
nanotechnology
synthetic
routes.
Considering
potential
natural
medicine,
aim
present
review
therefore
highlight
most
belonging
two
major
classes,
polyphenols
monoterpenes,
report
main
findings
about
action
relating
pathogenesis.
Biomolecules,
Год журнала:
2023,
Номер
13(11), С. 1598 - 1598
Опубликована: Окт. 31, 2023
Anthocyanins
are
a
type
of
flavonoids
that
give
plants
and
fruits
their
vibrant
colors.
They
known
for
potent
antioxidant
properties
have
been
linked
to
various
health
benefits.
Upon
consumption,
anthocyanins
quickly
absorbed
can
penetrate
the
blood-brain
barrier
(BBB).
Research
based
on
population
studies
suggests
including
anthocyanin-rich
sources
in
diet
lower
risk
neurodegenerative
diseases.
exhibit
neuroprotective
effects
could
potentially
alleviate
symptoms
associated
with
such
In
this
review,
we
compiled
discussed
large
body
evidence
supporting
role
anthocyanins.
Our
examination
encompasses
human
studies,
animal
models,
cell
cultures.
We
delve
into
connection
between
anthocyanin
bioactivities
mechanisms
underlying
neurodegeneration.
findings
highlight
how
anthocyanins'
antioxidant,
anti-inflammatory,
anti-apoptotic
contribute
effects.
These
particularly
relevant
key
signaling
pathways
implicated
development
Alzheimer's
Parkinson's
conclusion,
outcome
review
integrating
foods
diets
serve
as
therapeutic
approach
neurological
conditions,
identify
promising
avenues
further
exploration
area.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 27, 2023
Aging
is
an
inevitable
process
influenced
by
genetics,
lifestyles,
and
environments.
With
the
rapid
social
economic
development
in
recent
decades,
proportion
of
elderly
has
increased
rapidly
worldwide,
many
aging-related
diseases
have
shown
upward
trend,
including
nervous
system
diseases,
cardiovascular
metabolic
cancer.
The
rising
burden
become
urgent
global
health
challenge
requires
immediate
attention
solutions.
Natural
products
been
used
for
a
long
time
to
treat
various
human
diseases.
primary
cellular
pathways
that
mediate
longevity-extending
effects
natural
involve
nutrient-sensing
pathways.
Among
them,
sirtuin,
AMP-activated
protein
kinase,
mammalian
target
rapamycin,
p53,
insulin/insulin-like
growth
factor-1
signaling
are
most
widely
studied.
Several
studies
reviewed
individual
compounds
on
aging
along
with
underlying
mechanisms.
from
food
sources,
such
as
polyphenols,
saponins,
alkaloids,
polysaccharides,
classified
antiaging
promote
prolong
life
via
In
this
article,
we
several
recently
identified
potential
properties
highlighted
their
molecular
discovery
use
dietary
supplements
can
prevent
multiple
humans
will
be
beneficial.
Thus,
review
provides
theoretical
background
existing
agents.
