Future Pharmacology,
Год журнала:
2023,
Номер
3(1), С. 14 - 37
Опубликована: Янв. 4, 2023
Obesity
is
associated
with
a
significantly
increased
risk
of
cardiovascular
and
metabolic
diseases
such
as
diabetes
mellitus.
Recently,
growing
body
evidence
shows
that
phytochemicals,
especially
many
flavonoids,
place
an
inhibitory
regulatory
effect
on
adipogenesis,
obesity
diabetes.
With
computer-aided
drug
discovery,
the
action
modes
more
bioactive
flavonoids
are
being
identified
confirmed
at
molecular
level.
Citrus
fruit
peels
particularly
rich
in
which
have
demonstrated
strong
therapeutic
potentials
regulating
lipid
metabolisms.
However,
they
usually
thrown
away
after
consuming
flesh,
sometimes
even
causing
environmental
problems.
Thus,
extraction
useful
from
citrus
waste
for
pharmaceutical
industry
could
be
profitable
environmentally
friendly
solution
future,
advocating
concepts
circular
economy
sustainable
society.
The
aim
this
review
to
summarize
current
antiobesity
antidiabetic
extracted
fruits.
Our
results
suggest
various
potential
sources
novel
drugs
nutraceuticals.
Combining
experimental
data
artificial
intelligence
methods
study
would
facilitate
discovery
against
obesity-related
diseases.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2019 - 2019
Опубликована: Янв. 19, 2023
Bioactive
compounds,
including
terpenoids,
polyphenols,
alkaloids
and
other
nitrogen-containing
constituents,
exert
various
beneficial
effects
arising
from
their
antioxidant
anti-inflammatory
properties.
These
compounds
can
be
found
in
vegetables,
fruits,
grains,
spices
derived
foods
beverages
such
as
tea,
olive
oil,
fruit
juices,
wine,
chocolate
beer.
Agricultural
production
the
food
supply
chain
are
major
sources
of
wastes,
which
become
resources,
they
rich
bioactive
compounds.
The
aim
this
review
is
to
highlight
recent
articles
demonstrating
numerous
potential
uses
products
by-products
agro-food
chain,
have
applications.
Journal of Agricultural and Food Chemistry,
Год журнала:
2022,
Номер
70(23), С. 6805 - 6832
Опубликована: Май 11, 2022
Food
processing
sustainability,
as
well
waste
minimization,
are
key
concerns
for
the
modern
food
industry.
A
significant
amount
of
is
generated
by
fruit
juice
industry
each
year.
In
addition
to
economic
losses
caused
removal
these
wastes,
its
impact
on
environment
undeniable.
Therefore,
researchers
have
focused
recovering
bioactive
components
from
processing,
in
which
a
great
number
phytochemicals
still
exist
agro-industrial
help
minimize
burden
provide
new
sources
compounds,
believed
be
protective
agents
against
certain
diseases
such
cardiovascular
diseases,
cancer,
and
diabetes.
Although
wastes
contain
non-negligible
amounts
information
utilization
byproducts
functional
ingredient/food
production
their
sensory
quality
products
scarce.
this
regard,
review
summarizes
most
recent
literature
compounds
present
apple,
citrus
fruits,
berries,
stoned
melons,
tropical
juices,
together
with
extraction
techniques
valorization
approaches.
Besides,
one
hand,
examples
different
current
applications
use
provided.
On
other
challenges
respect
economic,
sensory,
safety
issues
also
discussed.
Cell,
Год журнала:
2022,
Номер
185(14), С. 2495 - 2509.e11
Опубликована: Июнь 27, 2022
Plant
fibers
in
byproduct
streams
produced
by
non-harsh
food
processing
methods
represent
biorepositories
of
diverse,
naturally
occurring,
and
physiologically
active
biomolecules.
To
demonstrate
one
approach
for
their
characterization,
mass
spectrometry
intestinal
contents
from
gnotobiotic
mice,
plus
vitro
studies,
revealed
liberation
N-methylserotonin
orange
human
gut
microbiota
members
including
Bacteroides
ovatus.
Functional
genomic
analyses
B.
ovatus
strains
grown
under
permissive
non-permissive
"mining"
conditions
polysaccharide
utilization
loci
that
target
pectins
whose
expression
correlate
with
strain-specific
this
compound.
N-methylserotonin,
orally
administered
to
germ-free
reduced
adiposity,
altered
liver
glycogenesis,
shortened
transit
time,
changed
genes
regulate
circadian
rhythm
the
colon.
In
dose-dependent,
orange-fiber-specific
fecal
accumulation
positively
correlated
levels
microbiome
encoding
enzymes
digest
pectic
glycans.
Identifying
type
microbial
mining
activity
has
potential
therapeutic
implications.
Molecules,
Год журнала:
2022,
Номер
27(5), С. 1580 - 1580
Опубликована: Фев. 27, 2022
In
this
work,
seven
Citrus
aurantium
essential
oils
(EOs)
derived
from
flavedo
of
cultivars
‘Canaliculata’,
‘Consolei’,
‘Crispifolia’,
‘Fasciata’,
‘Foetifera’,
‘Listata’,
and
‘Bizzaria’
were
investigated.
EOs
also
combined
in
1:1
(v/v)
ratio
to
identify
possible
synergism
or
antagonism
actions.
GC-MS
analysis
was
done
investigate
Eos’
phytochemical
profiles.
The
antioxidant
activity
studied
by
using
a
multi-target
approach
based
on
FRAP,
DPPH,
ABTS,
β-carotene
bleaching
tests.
A
great
difference
observed
EOs’
d-limonene
(33.35–89.17%)
the
main
monoterpene
hydrocarbon,
α-Pinene,
β-myrcene,
β-linalool
identified
almost
all
samples.
Among
EOs,
only
C3
showed
high
quantitative
qualitative
variability
its
chemical
composition.
diversity
demonstrated
PCA
HCA
statistical
analysis.
Samples
C2,
C4,
C5,
C6,
C7
statistically
similar
each
other,
while
C1
characterized
as
having
different
amount
other
compounds
oxygenated
monoterpenes,
respectively,
with
respect
mentioned.
global
score
(GAS)
revealed
that
among
tested
C.
‘Fasciata’
EO
had
highest
potential,
GAS
value
−0.47,
whereas
combinations,
obtained
mixing
‘Canaliculata’
+
most
active.
Comparison
theoretical
real
data
inhibitory
concentration
(IC50)
FRAP
values
did
not
reveal
any
significant
effect
actions
be
valid
biological
applied
These
findings,
considered
together,
represent
an
important
starting
point
understand
which
are
responsible
for
activities
their
future
industrial
application.
Journal of Agriculture and Food Research,
Год журнала:
2023,
Номер
14, С. 100718 - 100718
Опубликована: Июль 20, 2023
Citrus
fruits
belong
to
the
Rutaceae
family,
which
comprises
sweet
oranges,
sour
and
bitter
mandarins,
lemons,
limes,
grapefruit,
pomelo,
citrons,
etc,
a
wide
range
of
hybrids
cybrids.
The
presence
vitamin
flavonoid
enhance
nutritional
medicinal
properties.
Hesperidin,
found
in
citrus
is
one
major
flavonoids
binds
with
active
protein
site
severe
acute
respiratory
syndrome,
SARS-CoV-2
(Corona
Virus-2).
also
helps
boost
immunity.
Fruits
cannot
be
kept
for
longer
period
under
normal
conditions
due
postharvest
decay
causes
heavy
economic
losses
up
30%
total
production
can
go
50%
underdeveloped
countries.
This
post-harvest
loss
non-utilization
wastage
world
need
security
prevent
pandemic
hidden
hunger.
So,
it
required
process
fruit
form
canned
products,
squash,
juice,
juice
concentrate,
puree,
essential
oil,
pickle,
vinegar,
etc
enriched
&
fortified
products
such
as
vermicelli
or
cookies
orange
peel
powder
help
immunity
issues
utilization
citrus.
by-product
obtained
after
processing
used
extract
oil
pectin
from
waste.
value
addition,
enrichment,
fortification
reach
people
consumption
develop
Hence,
could
reduce
activity
against
COVID
virus;
resolve
issue
Antioxidants,
Год журнала:
2023,
Номер
12(6), С. 1238 - 1238
Опубликована: Июнь 8, 2023
This
study
investigated
chemical
composition,
cytotoxicity
in
normal
and
cancer
cells,
antimicrobial
antioxidant
activity
of
the
essential
oil
(EO)
isolated
by
hydrodistillation
from
discarded
leaves
lemon
(Citrus
limon)
plants
cultivated
Sardinia
(Italy).
The
volatile
composition
leaf
EO
(LLEO)
was
analyzed
with
gas
chromatography-mass
spectrometry
combined
flame
ionization
detection
(GC/MS
GC/FID).
most
abundant
component
LLEO
limonene
(260.7
mg/mL),
followed
geranial
(102.6
mg/mL)
neral
(88.3
mg/mL).
tested
using
eight
bacterial
strains
two
types
yeasts
a
microdilution
broth
test.
Candida
albicans
showed
greatest
susceptibility
(MIC
=
0.625
μL/mL)
Listeria
monocytogenes
Staphylococcus
aureus
were
inhibited
at
low
concentration
values
2.5
to
5
μL/mL).
C.
limon
displayed
radical
scavenging
ability
(IC50
value
10.24
2,2-diphenyl-1-picryl-hydrazylhydrate
(DPPH)
assay.
Furthermore,
impact
on
cell
viability
explored
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide
(MTT)
assay
HeLa
A375
melanoma
line,
fibroblasts
(3T3
cells),
keratinocytes
(HaCaT
cells).
LLEO,
24
h
incubation,
significantly
reduced
25
μM
Hela
cells
(33%
reduction)
(27%),
greatly
affecting
morphology,
whereas
this
effect
found
50
3T3
keratinocytes.
LLEO's
pro-oxidant
also
established
2',7'-dichlorodihydrofluorescein
diacetate
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2899 - 2899
Опубликована: Фев. 2, 2023
A
Mediterranean-style
diet
is
highly
encouraged
thanks
to
its
healthy
food
pattern,
which
includes
valuable
nutraceuticals
such
as
polyphenols.
Among
these,
flavonoids
are
associated
with
relevant
biological
properties
through
they
prevent
or
fight
the
onset
of
several
human
pathologies.
Globally,
enhanced
incidence
overweight
and
obese
people
has
caused
a
dramatic
increase
in
comorbidities,
raising
need
provide
better
therapies.
Therefore,
development
sophisticated
animal
models
metabolic
dysregulation
allowed
for
deepening
knowledge
on
this
subject.
Recent
advances
using
zebrafish
(Danio
rerio)
model
disease
have
yielded
fundamental
insights
into
potential
anti-obesity
effects
flavonoids.
Chronic
low-grade
inflammation
immune
system
activation
seem
characterize
pathogenesis
obesity;
thus,
their
reduction
might
improve
lipid
profile
patients
illnesses.
In
review,
we
highlight
beneficial
role
obesity
related
diseases
linked
anti-inflammatory
properties.
light
summarized
studies,
suggest
that
therapies
could
place
prevention
treatment
disorders.
