Molecules,
Год журнала:
2023,
Номер
29(1), С. 233 - 233
Опубликована: Дек. 31, 2023
Evernia
prunastri
is
a
lichen
widely
distributed
in
the
Northern
Hemisphere.
Its
biological
properties
still
need
to
be
discovered.
Therefore,
our
paper
focuses
on
studies
of
E.
extracts,
including
its
main
metabolites
evernic
acid
(EA)
or
atranorin
(ATR).
Phytochemical
profiles
using
chromatographic
analysis
were
confirmed.
The
antioxidant
activity
was
evaluated
vitro
chemical
tests
and
enzymatic
cells-free
tests,
namely
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GPx),
reductase
(GR),
catalase
(CAT).
anti-inflammatory
potential
cyclooxygenase-2
(COX-2)
hyaluronidase
determined.
neuroprotective
acetylcholinesterase,
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase
(Tyr)
estimated.
hypoglycemic
also
confirmed
(α-glucosidase).
Principal
component
performed
determine
relationship
between
extracts.
inhibitory
effect
EA
ATR
COX-2
AChE,
BChE,
Tyr,
α-glucosidase
molecular
docking
techniques
for
(besides
α-glucosidase).
penetration
from
extracts
through
blood–brain
barrier
parallel
artificial
membrane
permeability
assay
test.
In
conclusion,
depending
surroundings
concentration,
ATR,
showed
attractive
pleiotropic
properties,
which
should
further
investigated.
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2022,
Номер
41(20), С. 10869 - 10884
Опубликована: Дек. 28, 2022
The
spike
(S)
glycoprotein
and
nucleocapsid
(N)
proteins
are
the
crucial
pathogenic
of
Severe
Acute
Respiratory
Syndrome
Coronavirus-2
(SARS
CoV-2)
virus
during
its
interaction
with
host.
Even
FDA-approved
drugs
like
dexamethasone
grazoprevir
not
able
to
curb
viral
progression
inside
host
reported
adverse
effects
on
body
metabolism.
In
this
context,
we
aim
report
corilagin
a
novel,
potential
dual
inhibitor
S
N
from
Terminalia
chebula.
bioactive
compounds
T.
chebula
were
subjected
series
computational
investigations
including
molecular
docking
simulations,
dynamics
(MD)
binding
free
energy
calculations,
PASS
pharmacological
analysis.
results
obtained
these
studies
revealed
that
was
highly
interactive
(-8.9
kcal/mol)
(-9.2
proteins,
thereby
showing
inhibition
activity.
It
also
found
be
stable
enough
induce
biological
activity
pocket
target
enzymes
throughout
simulation
run
for
100
ns.
This
is
confirmed
by
changes
in
protein
conformations,
evaluated
using
landscapes.
Outcomes
investigation
identify
as
lead
SARS-CoV-2,
which
could
taken
near
future.Communicated
Ramaswamy
H.
Sarma.
Molecules,
Год журнала:
2023,
Номер
29(1), С. 233 - 233
Опубликована: Дек. 31, 2023
Evernia
prunastri
is
a
lichen
widely
distributed
in
the
Northern
Hemisphere.
Its
biological
properties
still
need
to
be
discovered.
Therefore,
our
paper
focuses
on
studies
of
E.
extracts,
including
its
main
metabolites
evernic
acid
(EA)
or
atranorin
(ATR).
Phytochemical
profiles
using
chromatographic
analysis
were
confirmed.
The
antioxidant
activity
was
evaluated
vitro
chemical
tests
and
enzymatic
cells-free
tests,
namely
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GPx),
reductase
(GR),
catalase
(CAT).
anti-inflammatory
potential
cyclooxygenase-2
(COX-2)
hyaluronidase
determined.
neuroprotective
acetylcholinesterase,
(AChE),
butyrylcholinesterase
(BChE),
tyrosinase
(Tyr)
estimated.
hypoglycemic
also
confirmed
(α-glucosidase).
Principal
component
performed
determine
relationship
between
extracts.
inhibitory
effect
EA
ATR
COX-2
AChE,
BChE,
Tyr,
α-glucosidase
molecular
docking
techniques
for
(besides
α-glucosidase).
penetration
from
extracts
through
blood–brain
barrier
parallel
artificial
membrane
permeability
assay
test.
In
conclusion,
depending
surroundings
concentration,
ATR,
showed
attractive
pleiotropic
properties,
which
should
further
investigated.
