Enhanced Antioxidant and Neuroprotective Properties of Pterostilbene (Resveratrol Derivative) in Amorphous Solid Dispersions
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2774 - 2774
Опубликована: Фев. 28, 2024
In
this
study,
amorphous
solid
dispersions
(ASDs)
of
pterostilbene
(PTR)
with
polyvinylpyrrolidone
polymers
(PVP
K30
and
VA64)
were
prepared
through
milling,
affirming
the
dispersion
PTR
via
X-ray
powder
diffraction
(XRPD)
differential
scanning
calorimetry
(DSC).
Subsequent
analysis
DSC
thermograms,
augmented
using
mathematical
equations
such
as
Gordon–Taylor
Couchman–Karasz
equations,
facilitated
determination
predicted
values
for
glass
transition
(Tg),
PTR’s
miscibility
PVP,
strength
interaction
polymers.
Fourier-transform
infrared
(FTIR)
validated
interactions
maintaining
state
identified
involved
functional
groups,
namely,
4′–OH
and/or
–CH
groups
C=O
group
PVP.
The
study
culminated
in
evaluating
impact
amorphization
on
water
solubility,
release
profile
pH
6.8,
vitro
permeability
(PAMPA-GIT
BBB
methods).
addition,
it
was
determined
how
improving
solubility
affects
increase
antioxidant
(ABTS,
DPPH,
CUPRAC,
FRAP
assays)
neuroprotective
(inhibition
cholinesterases:
AChE
BChE)
properties.
apparent
pure
~4.0
µg·mL−1
showed
no
activity
considered
assays.
For
obtained
ASDs
(PTR-PVP30/PTR-PVPVA64,
respectively)
improvements
(410.8
383.2
µg·mL−1),
profile,
permeability,
properties
(ABTS:
IC50
=
52.37/52.99
μg·mL−1,
DPPH:
163.43/173.96
CUPRAC:
IC0.5
122.27/129.59
FRAP:
95.69/98.57
μg·mL−1),
effects
(AChE:
39.1%/36.2%,
BChE:
76.9%/73.2%)
confirmed.
Язык: Английский
Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects
Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 526 - 526
Опубликована: Апрель 10, 2024
Pomegranate
flower
extract,
rich
in
anthocyanins,
demonstrates
beneficial
health-promoting
properties
such
as
an
anti-diabetic
and
antioxidant
effect,
among
others.
However,
the
potential
may
be
hindered
by
low
stability
of
anthocyanins.
Therefore,
aim
our
study
was
to
assess
whether
stabilizing
carriers,
namely
HP-γ-cyclodextrin
(HP-γ-CD),
α-cyclodextrin
(α-CD),
Methyl-β-cyclodextrin
(Me-β-CD),
Inulin
(Inu)
Arabic
gum
(AGu)
affect
antidiabetic
activity
lyophilized
pomegranate
how
they
influence
stability,
release
profile,
systems
exhibit
prebiotic
activity.
Interactions
between
extract
these
factors
were
analyzed
using
FT-IR.
The
structures
examined
through
microscopic
imaging
while
for
prepared
systems,
determined
confirmed
inhibition
α-amylase
α-glucosidase;
expressed
DPPH
CUPRAC
assays.
content
pelargonidin-3,5-glucoside
assessed
HPLC
method.
profiles
a
medium
at
pH
=
6.8
1.2,
after
subjecting
high
temperatures
(T
90
°C).
evaluated
10
bacterial
strains
(Lactobacillus
acidophilus,
Lactobacillus
casei,
plantarum,
brevis
rhamnosus
gg,
reuteri,
Pediococcus
pentosaceus,
Lactococcus
lactis,
fermentum
lf,
Streptococcus
thermophilus).
As
result
conducted
research,
better
functionalities
obtained
containing
proven
terms
effects.
delivery
allow
use
its
Язык: Английский
Elderberry Leaves with Antioxidant and Anti-Inflammatory Properties as a Valuable Plant Material for Wound Healing
Pharmaceuticals,
Год журнала:
2024,
Номер
17(5), С. 618 - 618
Опубликована: Май 10, 2024
Sambuci
folium
(elderberry
leaves)
have
been
used
in
traditional
medicine,
mainly
externally,
to
treat
skin
diseases
and
wounds.
Therefore,
the
aim
of
this
study
was
screen
biological
activity
elderberry
leaves
(antioxidant
potential
possibility
inhibition
tyrosinase
hyaluronidase
enzymes)
combined
with
phytochemical
analysis.
For
purpose,
a
analysis
carried
out.
Elderberry
12
varieties
(“Sampo”,
“Obelisk”,
“Dwubarwny”,
“Haschberg”,
“Haschberg
1”,
“Koralowy”,
“Sambo”,
“Black
Beauty”,
Tower”,
“Golden
hybrid”,
“Samyl”,
“Samyl
1”)
two
growth
stages.
The
compounds
from
selected
groups,
phenolic
acids
(chlorogenic
acid)
flavonols
(quercetin),
were
chromatographically
determined
hydroalcoholic
leaf
extracts.
All
tested
extracts
showed
antioxidant
effects,
but
most
promising
potential:
very
high
content
(TPC
=
61.85
mg
GAE/g),
(e.g.,
DPPH
IC50
1.88
mg/mL;
CUPRAC
IC0.5
0.63
mg/mL)
optimal
anti-inflammatory
(inhibition
41.28%)
activities
indicated
for
older
“Sampo”
variety.
Additionally,
extract
obtained
hybrid”
variety
facilitated
treatment
wounds
scratch
test.
In
summary,
best
multidirectional
pro-health
effect
treating
inflammation
specified
II
(leaves
during
flowering
period);
however,
wound
noted
as
rich
chlorogenic
acid
younger
Язык: Английский
Paeoniflorin inhibits pyruvate dehydrogenase kinase 3 and promotes BDNF activity by modulating neuronal activity and TNF-α
Pinky Pinky,
Saleha Anwar,
Neha Neha
и другие.
Brain Research,
Год журнала:
2025,
Номер
unknown, С. 149476 - 149476
Опубликована: Янв. 1, 2025
Язык: Английский
Chemical Profiling and In Vitro Evaluation of Bioactive Properties of Evernia prunastri Extract: Implications for Therapeutic Applications
Plants,
Год журнала:
2025,
Номер
14(4), С. 583 - 583
Опубликована: Фев. 14, 2025
Evernia
prunastri
(L.)
Ach.
(Parmeliaceae),
an
edible
lichen
commonly
known
as
oakmoss,
was
traditionally
used
by
Egyptians
to
make
bread.
In
this
study,
the
ethyl-acetate
(EtOAc)
extract
of
E.
investigated
for
its
potential
therapeutic
applications
in
diabetes
mellitus,
Alzheimer's
and
Parkinson's
diseases,
oxidative
stress,
bacterial
infections.
The
exhibited
significant
vitro
enzyme
inhibition
activities,
including
anti-amylase
anti-glucosidase
activities
linked
anti-cholinesterase
anti-tyrosinase
associated
with
diseases.
antioxidant
activity
evaluated
through
multiple
assays,
free
radical
scavenging
(DPPH
ABTS),
reducing
power
(CUPRAC
FRAP),
metal
chelation,
phosphomolybdenum
methods,
demonstrating
strong
stress
relief
potential.
antibacterial
properties
were
also
confirmed
testing,
showing
efficacy
against
a
range
strains.
Total
phenolic
flavonoid
contents
quantified,
while
chemical
profile
EtOAc
determined
LC-HRMS/MS
analysis.
composition
predominantly
characterized
depsides
(evernic
acid
atranorin),
acids
(orsellinic
acid),
dibenzofurans,
revealing
diverse
array
bioactive
secondary
metabolites.
demonstrated
broad
spectrum
biological
inhibition,
effects,
properties.
This
study
highlights
functional
food,
providing
rich
source
compounds
numerous
health-promoting
it
suggests
relevance
chronic
diseases
such
diabetes,
Alzheimer's,
Язык: Английский
Towards the Use of Lichens as a Source of Bioactive Substances for Topical Applications
Molecules,
Год журнала:
2024,
Номер
29(18), С. 4352 - 4352
Опубликована: Сен. 13, 2024
The
increasing
incidence
of
dermatological
diseases
prompts
the
search
for
new
natural
methods
treatments,
and
lichens,
with
their
special
symbiotic
structure,
are
a
little-known
promising
source
biologically
active
substances.
Seven
lichen
species,
Язык: Английский
A systematic study of some lichenized fungi from Pakistan using nrITS marker
Italian Botanist,
Год журнала:
2024,
Номер
18, С. 75 - 96
Опубликована: Ноя. 18, 2024
In
a
detailed
investigation
of
lichen
diversity
in
different
regions
Pakistan,
utilizing
molecular
and
morphological
techniques,
we
identified
reported
three
species
–
Dimelaena
altissima
,
Lecanora
chlarotera
Usnea
lapponica
as
new
records
for
Pakistan.
Furthermore,
nrITS
sequences
Evernia
prunastri
horiza
L.
hybocarpa
Peltigera
polydactylon
P.
praetextata
were
generated
the
first
time
from
Detailed
morpho-anatomical
descriptions,
habitat
information,
distribution
data,
results
biochemical
analyses
are
also
provided
better
understanding
ecology
this
region.
Язык: Английский