Tetrahedron Chem,
Год журнала:
2023,
Номер
9, С. 100061 - 100061
Опубликована: Дек. 25, 2023
In
the
last
twenty
years,
electrochemistry
and
photochemistry
have
attracted
a
renewed
still
uprising
interest
in
organic
synthesis.
Two
of
most
simple
abundant
reagents,
electrons
photons,
became
key
players
synthetic
chemistry
as
cornerstones
developing
greener
sustainable
chemical
processes.
An
interesting
strategy
that
recently
emerged
is
possibility
merging
two
worlds
what
called
ElectroPhotoChemistry
(EPC).
particular,
this
review
will
focus
on
recent
contributions
field.
The
basic
principles
EPC
be
presented
along
with
discussion
published
works
few
years.
Electrophotochemical
oxidation/reduction
reactions
discussed,
including
section
transformations
C–H
bond
to
C-X
(X:
heteroatom).
activation
chapter
formation
C–C
bond,
starting
from
considered.
Finally,
miscellaneous
includes
examples
which
do
not
clearly
belong
previous
categories.
Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(16), С. 1921 - 1930
Опубликована: Апрель 7, 2023
Comprehensive
Summary
The
radical‐mediated
reductive
functionalization
of
aryl
halides
has
been
extensively
studied.
However,
the
related
intermolecular
1,2‐diarylation
alkenes,
using
as
radical
sources,
remains
unexplored.
Herein,
a
new
electrophotocatalytic
alkenes
is
reported
and
cyanoaromatics
to
produce
polyarylated
alkanes.
Using
synergistic
cathodic
reduction
visible‐light
photoredox
catalysis,
various
electron‐rich
electron‐deficient
are
combined
with
characterize
broad
substrate
scope,
excellent
functional
group
compatibility,
selectivity
this
reaction.
Mechanistic
investigations
reveal
that
reaction
may
proceed
via
process
initiated
by
generation
radicals
from
terminated
radical‐radical
coupling
cyanoaromatic
anions.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(31)
Опубликована: Март 28, 2024
Abstract
Photoinduced
aryl
radical
generation
is
a
powerful
strategy
in
organic
synthesis
that
facilitates
the
formation
of
diverse
carbon‐carbon
and
carbon‐heteroatom
bonds.
The
synthetic
applications
photoinduced
complex
compounds,
including
natural
products,
physiologically
significant
molecules,
functional
materials,
have
received
immense
attention.
An
overview
current
developments
production
methods
their
uses
given
this
article.
A
generalized
idea
how
to
choose
reagents
approach
for
radicals
described,
along
with
techniques
associated
mechanistic
insights.
Overall,
article
offers
critical
assessment
results
as
well
selection
reaction
parameters
specific
context
cascades,
cross‐coupling
reactions,
functionalization,
selective
C−H
functionalization
substrates.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(8), С. 1719 - 1737
Опубликована: Фев. 29, 2024
Abstract
Aryl
halides
are
one
of
the
most
important
chemical
feedstocks
in
pharmaceuticals
due
to
its
easy
accessibility,
inexpensiveness,
and
widely
utilized
as
aryl
radical
precursors
organic
synthetic
chemistry.
Conventionally,
stoichiometric
reagents
such
AIBN/n‐Bu
3
SnH
were
used
for
generation
from
halides,
suffered
requirement
toxic
initiators,
high
temperature
thus,
development
simple,
mild
strategies
highly
desirable.
Recently,
visible
light
mediated
received
considerable
attention,
allowing
under
reaction
conditions.
The
present
review
described
recent
breakthroughs
advancements
photocatalyst‐free
C−B/C/O/P/Se/S
bond
formation
halides.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
The
advancement
in
electrochemical
techniques
has
unlocked
a
new
path
for
achieving
unprecedented
oxidations
and
reductions
of
aryl
radical
precursors
controlled
selective
manner.
This
approach
facilitates
the
construction
aromatic
carbon-carbon
carbon-heteroatom
bonds.
In
light
green
merits
growing
importance
this
technique
chemistry,
review
aims
to
provide
an
overview
recent
advance
generation
radicals
organized
by
precursor
type,
with
focus
on
substrate
scope,
limitation,
underlying
mechanism,
thereby
inspiring
future
work
generation.
ACS Catalysis,
Год журнала:
2023,
Номер
13(20), С. 13414 - 13422
Опубликована: Окт. 3, 2023
The
conversion
of
feedstock
materials
into
useful
chemical
compounds
through
feasible
processes
is
highly
sought
after
from
both
industrial
and
environmental
perspectives.
In
this
study,
we
developed
a
simple
scalable
protocol
for
synthesizing
aldehydes,
ketones,
amides
abundant
raw
materials,
such
as
alkanes,
alkenes,
carboxylic
acids.
Using
photoactive
mesoporous
graphitic
carbon
nitride
catalyst
(mpg-CN)
molecular
oxygen,
successfully
transformed
over
60
substrates
in
good
yield
selectivity.
This
method
suitable
the
late-stage
modification
existing
drug
molecules
their
corresponding
carbonyl
derivatives
can
provide
direct
access
to
intermediates
or
oxidative
decomposition
degradation
products
important
understanding
biological
pathways
development.
Additionally,
our
applicable
large-scale
preparation,
mpg-CN
be
recycled
without
significant
loss
catalytic
activity
Comprehensive
experiments,
including
labeled
oxygen
studies,
support
photo-oxidative
mechanism.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4318 - 4342
Опубликована: Янв. 1, 2024
This
review
primarily
focuses
on
the
generation
of
aryl
radicals
via
an
electroreduction
strategy,
and
systematically
elaborates
synthetic
applications,
scope,
limitations
substrates.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5232 - 5277
Опубликована: Янв. 1, 2024
This
review
describes
recent
advances
in
the
generation
of
aryl
radicals
using
light
and
electricity.
Such
modern
techniques
allow
for
efficient
energy
resource
utilization,
thus
providing
more
sustainable
radical
arylation
methods.
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 1294 - 1304
Опубликована: Янв. 7, 2025
Given
the
widespread
presence
of
spirocyclic
scaffolds
in
natural
products
and
pharmacologically
relevant
synthetic
compounds,
development
efficient
methodologies
for
their
construction
holds
great
importance
medicinal
chemistry
pharmaceutical
research.
In
this
study,
a
general
photochemical
dearomative
spirocyclization
nonactivated
arenes
has
been
established.
The
key
to
method
lies
ability
amine-borane
radicals
activate
aryl
bromides
iodides
via
halogen-atom
transfer,
thereby
allowing
conversion
halides
into
corresponding
subsequent
chemodivergent
transformations.
remarkable
compatibility
versatility
1,4-difunctionalization
is
showed
by
rapid
assembly
structurally
diverse
1,4-cyclohexadiene-based
spirocycles
incorporating
oxindole,
indoline,
or
dihydrobenzofuran
subunits.
Moreover,
potential
utility
protocol
exemplified
formal
total
synthesis
vasopressin
V2
receptor
antagonist
Satavaptan.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
We
report
herein
that
photoinduced
CO2•–
enabled
reductive
intramolecular
radical
cyclization
of
a
variety
aryl
iodide
derivatives
to
the
corresponding
phenanthridinone,
oxindole,
isoindolinone,
and
spirolactam
in
good
yields.
Preliminary
mechanistic
studies
suggested
generation
through
homolysis
cesium
formate
presence
light,
further
involvement
was
directly
proved
by
trapping
with
diphenyl
styrene
TEMPO.
