Cell Death and Disease,
Год журнала:
2024,
Номер
15(6)
Опубликована: Июнь 19, 2024
Abstract
With
the
high
incidence
of
urogenital
tumors
worldwide,
urinary
system
are
among
top
10
most
common
in
men,
with
prostate
cancer
ranking
first
and
bladder
fourth.
Patients
resistant
often
have
poor
prognosis.
In
recent
years,
researchers
discovered
numerous
specific
antigens,
which
has
led
to
development
several
new
anti-cancer
drugs.
Using
protein
analysis
techniques,
developed
immune
checkpoint
inhibitors
(ICIs)
antibody-conjugated
drugs
(ADCs)
for
treatment
advanced
tumors.
However,
tumor
resistance
leads
failure
monotherapy.
Therefore,
clinical
trials
combination
ICIs
ADCs
been
carried
out
centers
around
world.
This
article
reviewed
phase
2
3
studies
ICIs,
ADCs,
their
highlight
safe
effective
methods
selecting
individualized
therapeutic
strategies
patients.
activate
system,
whereas
link
monoclonal
antibodies
toxins,
can
achieve
a
synergistic
effect
when
two
combined.
provides
multiple
advantages
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
This
review
explores
the
synthesis,
drug
loading,
and
surface
modifications
of
metal–organic
frameworks
(MOFs),
highlighting
their
role
in
improving
cancer
immunotherapy
paving
way
for
safer
more
effective
treatments.
Degenerative Neurological and Neuromuscular Disease,
Год журнала:
2024,
Номер
Volume 14, С. 33 - 46
Опубликована: Май 1, 2024
Abstract:
Prostate
cancer
(PCa)
is
one
of
the
most
prevalent
malignancies
affecting
males
worldwide.
Despite
reductions
in
mortality
rates
due
to
advances
early
identification
and
treatment
methods,
PCa
remains
a
major
health
concern.
Recent
research
has
shed
light
on
possible
link
between
Alzheimer's
disease
(AD),
which
significant
neurological
ailment
that
affects
older
all
over
world.
Androgen
deprivation
therapy
(ADT),
cornerstone
therapeutic
method
used
conjunction
with
radiation
palliative
care
advanced
metastatic
cases,
critical
for
management.
Evidence
reveals
relationship
ADT
cognitive
impairment.
Hormonal
manipulation
may
cause
long-term
problems
through
processes
such
as
amyloid
beta
(Aβ)
aggregation
neurofibrillary
tangles
(NFTs).
Fluctuations
basal
androgen
levels
can
upset
delicate
balance
genes
are
sensitive
levels,
contributing
This
detailed
review
dives
into
various
aspects
aetiology
its
decline.
It
investigates
discovery
particular
biomarkers,
well
microRNAs
(miRNAs),
play
important
roles
pathogenic
progression.
The
attempts
identify
potential
biomarkers
associated
ADT-induced
cerebral
changes,
including
Aβ
oligomer
buildup,
NFT
formation,
tauopathy,
contribute
early-onset
dementia
Besides
it
further
aims
provide
insights
innovative
diagnostic
avenues
alleviating
ADT-related
sequelae
by
unravelling
these
complicated
pathways
molecular
mechanisms.
Keywords:
cancer,
dementia,
defects,
androgen,
testosterone
Cancers,
Год журнала:
2024,
Номер
16(8), С. 1554 - 1554
Опубликована: Апрель 18, 2024
Cancer
is
a
life-threatening
disease
and
one
of
the
leading
causes
death
worldwide.
Despite
significant
advancements
in
therapeutic
options,
most
available
anti-cancer
agents
have
limited
efficacy.
In
this
context,
natural
compounds
with
diverse
chemical
structures
been
investigated
for
their
multimodal
properties.
Curcumin
polyphenol
isolated
from
rhizomes
Curcuma
longa
has
widely
studied
its
anti-inflammatory,
anti-oxidant,
effects.
acts
on
regulation
different
aspects
cancer
development,
including
initiation,
metastasis,
angiogenesis,
progression.
The
phosphatidylinositol-3-kinase
(PI3K)/protein
kinase
B
(AKT)
pathway
key
target
therapy,
since
it
implicated
proliferation,
cell
survival.
found
to
inhibit
PI3K/Akt
tumor
cells,
primarily
via
mediators,
growth
factors,
protein
kinases,
cytokines.
This
review
presents
potential
curcumin
malignancies,
such
as
glioblastoma,
prostate
breast
cancer,
head
neck
cancers,
through
targeting
signaling
pathway.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Ноя. 29, 2024
Cancer
is
the
second
most
common
cause
of
death
globally.
Therefore,
it
imperative
to
investigate
cancer
incidence,
mortality
rates,
and
disability-adjusted
life
years
(DALYs)
enhance
preventive
measures
healthcare
resource
allocation.
This
study
aimed
assess
burden
associated
risk
factors
in
204
countries
territories
between
1980
2021.
We
selected
data
on
incidence
rates
from
global
disease
(GBD)
tool
for
1990
2021
estimated
age-standardized
(ASIR)
deaths
(ASDR)
34
types
categorized
as
level
3
causes
based
GBD
hierarchy.
In
2021,
accounted
14.57%
(95%
uncertainty
interval:
13.65–15.28)
total
8.8%
(7.99–9.67)
DALYs
both
sexes
ASIR
ASDR
were
790.33
(694.43–893.01)
116.49
(107.28–124.69),
respectively.
Additionally,
females
exhibited
higher
than
males
(923.44
versus
673.09),
while
(145.69
93.60).
indicates
that
policymakers
should
focus
importance
gender
equality
healthcare.
Non-melanoma
skin
highest
(74.10)
sexes,
digestive
cancers
39.29%
all
cancer-related
deaths,
Asia
heaviest
burden.
females,
breast
(46.40)
(14.55).
males,
tracheal,
bronchial,
lung
(37.85)
(34.32),
highlighting
urgent
need
targeted
tobacco
control
measures.
Different
various
exhibit
unique
characteristics.
formulate
specific
prevention
strategies
reflect
their
country.
Tobacco
was
primary
2
factor
males.
It
29.32%
(25.32–33.14)
DALYs.
Dietary
risks,
alcohol
consumption,
air
pollution
5.89%
(2.01–10.73),
5.48%
(4.83–6.11),
4.30%
(2.77–5.95)
male
DALYs,
prioritize
smoking
regulation
other
carcinogenic
risks.
a
significant
public
health
concern
Understanding
etiologies
different
essential
developing
effective
interventions.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 22, 2024
Abstract
Prostate
cancer
(PCa)
is
one
of
the
most
common
malignancy
in
men.
However,
molecular
mechanism
its
pathogenesis
has
not
yet
been
elucidated.
In
this
study,
we
demonstrated
that
CYLD,
a
novel
deubiquitinating
enzyme,
impeded
PCa
development
and
progression
via
tumor
suppression.
First,
found
CYLD
was
downregulated
tissues,
expression
inversely
correlated
with
pathological
grade
clinical
stage.
Moreover,
discovered
inhibited
cell
proliferation
enhanced
sensitivity
to
ferroptosis
vitro
vivo,
respectively.
Mechanistically,
suppressed
ubiquitination
YAP
protein,
then
promoted
ACSL4
TFRC
mRNA
transcription.
Then,
could
enhance
xenografts
vivo.
Furthermore,
for
first
time
there
positive
correlation
between
or
human
specimens.
The
results
study
suggested
acted
as
suppressor
gene
through
Hippo/YAP
signaling.
Chemical Science,
Год журнала:
2024,
Номер
15(17), С. 6488 - 6499
Опубликована: Янв. 1, 2024
In
recent
years,
castration-resistant
prostate
cancer
(CRPC)
has
profoundly
impacted
the
lives
of
many
men,
and
early
diagnosis
medication
illness
is
crucial.
Therefore,
a
highly
efficient
detection
method
for
CRPC
biomarkers
curing
drugs
required.
However,
complex
diverse
structures
pose
significant
challenges
their
differentiation.
Lanthanide
metal-organic
frameworks
(Ln-MOFs)
show
great
potential
sensing
applications
due
to
intense
characteristic
luminescence.
this
work,
series
new
bimetallic
Ln-MOFs
(Eu
