Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(38), С. 3009 - 3017
Опубликована: Авг. 20, 2024
:
Medicinal
herbs
have
been
utilized
in
the
treatment
of
various
pathologic
conditions,
including
neoplasms,
organ
fibrosis,
and
diabetes
mellitus.
However,
precise
pharmacological
actions
plant
miRNAs
animals
remain
to
be
fully
elucidated,
particularly
terms
their
therapeutic
efficacy
mechanism
action.
In
this
review,
some
important
from
foods
medicinal
are
presented.
Plant
exhibit
a
range
properties,
such
as
anti-cancer,
anti-fibrosis,
anti-viral,
anti-inflammatory
effects,
neuromodulation,
among
others.
These
results
not
only
demonstrated
cross-species
regulatory
effect,
but
also
suggested
that
bioactive
components.
This
shows
promising
prospect
for
used
drugs.
Here,
properties
underlying
mechanisms
highlighted,
which
can
provide
new
insights
clarifying
suggest
way
developing
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(4), С. 2556 - 2570
Опубликована: Янв. 26, 2024
Herein,
we
report
a
highly
efficient
Ag(I)-catalyzed
indolyzation
with
Friedel–Crafts
alkylation
through
cascade
cyclization
strategy
for
accessing
valuable
hybrid
heterocycles
the
first
time.
This
general
consists
of
forming
four
C–C/C–N/C–O
bonds
toward
dual
annulation
reactions
2-alkynylanilines
methyl
benzoate-2-carboxaldehydes
and
aromatic
amines,
as
well
salicylaldehydes
malononitrile.
Variably
substituted
new
indolo-4H-phthalimidines
indolo-4H-chromenes
were
synthesized
excellent
yields
(85–93%)
under
mild
reaction
conditions.
Abstract
Angiogenesis,
vital
for
tumor
growth
and
metastasis,
is
a
promising
target
in
cancer
therapy.
Natural
compounds
offer
potential
as
antiangiogenic
agents
with
reduced
toxicity.
This
review
provides
comprehensive
overview
of
natural
product‐based
therapies,
focusing
on
molecular
mechanisms
therapeutic
potential.
A
systematic
search
identified
relevant
articles
from
2019
to
2023.
Various
compounds,
including
polyphenols,
terpenes,
alkaloids,
cannabinoids,
omega‐3
fatty
acids,
polysaccharides,
proteins,
carotenoids,
were
investigated
their
properties.
Challenges
such
dose
standardization,
routes
administration,
side
effects
remain.
Further
studies,
in‐depth
animal
models
human
epidemiological
must
elucidate
clinical
efficacy
safety.
Synergistic
current
bevacizumab
tyrosine
kinase
inhibitors,
should
be
explored.
Additionally,
the
hormone‐dependent
like
genistein
highlight
need
safety
evaluation.
In
conclusion,
products
hold
promise
adjunctive
therapies
conventional
antineoplastic
drugs
modulating
angiogenesis
cancer.
However,
robust
trials
are
needed
validate
preclinical
findings
ensure
efficacy.
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1414 - 1414
Опубликована: Фев. 2, 2023
Efficient
and
mild
synthetic
routes
for
bioactive
natural
product
derivatives
are
of
current
interest
drug
discovery.
Herein,
on
the
basis
pharmacophore
hybrid
strategy,
we
report
a
two-step
protocol
to
obtain
series
structurally
novel
oleanolic
acid
(OA)-dithiocarbamate
conjugates
in
conditions
with
high
yields.
Moreover,
biological
evaluations
indicated
that
representative
compound
3e
exhibited
most
potent
broad-spectrum
antiproliferative
effects
against
Panc1,
A549,
Hep3B,
Huh-7,
HT-29,
Hela
cells
low
cytotoxicity
normal
cells.
In
terms
IC50
values,
these
OA-dithiocarbamate
were
up
30-fold
more
than
OA.
These
compounds
may
be
promising
hit
development
anti-cancer
drugs.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 886 - 886
Опубликована: Март 9, 2023
New
lignohydroquinone
conjugates
(L-HQs)
were
designed
and
synthesized
using
the
hybridization
strategy,
evaluated
as
cytotoxics
against
several
cancer
cell
lines.
The
L-HQs
obtained
from
natural
product
podophyllotoxin
some
semisynthetic
terpenylnaphthohydroquinones,
prepared
terpenoids.
Both
entities
of
connected
through
different
aliphatic
or
aromatic
linkers.
Among
hybrids,
L-HQ
with
spacer
clearly
displayed
in
vitro
dual
cytotoxic
effect
derived
each
starting
component,
retaining
selectivity
showing
a
high
cytotoxicity
at
short
(24
h)
long
(72
incubation
times
(4.12
0.0450
µM,
respectively)
colorectal
cells.
In
addition,
cycle
blockade
observed
by
flow
cytometry
studies,
molecular
dynamics,
tubulin
interaction
studies
demonstrated
interest
this
kind
which
docked
adequately
into
colchicine
binding
site
despite
their
large
size.
These
results
prove
validity
strategy
encourage
further
research
on
non-lactonic
cyclolignans.
Molecules,
Год журнала:
2024,
Номер
29(17), С. 4193 - 4193
Опубликована: Сен. 4, 2024
The
emergence
of
natural
products
has
provided
extremely
valuable
references
for
the
treatment
various
diseases.
Cucurbitacin
B,
a
tetracyclic
triterpenoid
compound
isolated
from
cucurbitaceae
and
other
plants,
is
most
abundant
member
cucurbitin
family
exhibits
wide
range
biological
activities,
including
anti-inflammatory,
anti-cancer,
even
agricultural
applications.
Due
to
its
high
toxicity
narrow
therapeutic
window,
structural
modification
dosage
form
development
are
necessary
address
these
issues
with
cucurbitacin
B.
This
paper
reviews
recent
research
progress
in
pharmacological
action,
modification,
application
review
aims
enhance
understanding
advancements
this
field
provide
constructive
suggestions
further
on
Glioblastoma
(GBM)
remains
a
formidable
challenge
in
neuro-oncology
due
to
its
aggressive
nature
and
propensity
for
therapeutic
resistance.
Anti-vascular
endothelial
growth
factor
(VEGF)
therapies,
although
promising,
often
encounter
resistance
that
limits
their
clinical
efficacy.
A
multi-target
multi-drug
approach
has
emerged
as
compelling
strategies
address
this
enhance
the
treatment
outcomes.
This
review
examines
complex
environment
of
anti-VEGF
resistant
GBM
analyses
using
natural
products.
