Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(38), С. 3009 - 3017
Опубликована: Авг. 20, 2024
:
Medicinal
herbs
have
been
utilized
in
the
treatment
of
various
pathologic
conditions,
including
neoplasms,
organ
fibrosis,
and
diabetes
mellitus.
However,
precise
pharmacological
actions
plant
miRNAs
animals
remain
to
be
fully
elucidated,
particularly
terms
their
therapeutic
efficacy
mechanism
action.
In
this
review,
some
important
from
foods
medicinal
are
presented.
Plant
exhibit
a
range
properties,
such
as
anti-cancer,
anti-fibrosis,
anti-viral,
anti-inflammatory
effects,
neuromodulation,
among
others.
These
results
not
only
demonstrated
cross-species
regulatory
effect,
but
also
suggested
that
bioactive
components.
This
shows
promising
prospect
for
used
drugs.
Here,
properties
underlying
mechanisms
highlighted,
which
can
provide
new
insights
clarifying
suggest
way
developing
As
part
of
valorisation
agricultural
waste
into
bioactive
compounds,
a
series
structurally
novel
oleanolic
acid
((3β-hydroxyolean-12-en-28-oic
acid,
OA-1)-phtalimidines
(isoindolinones)
conjugates
18a-v
bearing
1,2,3-triazole
moieties
were
designed
and
synthesized
by
treating
previously
azide
4
prepared
from
OA-1
isolated
olive
pomace
(Olea
europaea
L.)
with
wide
range
propargylated
phtalimidines
using
the
Cu(I)-catalyzed
click
chemistry
approach.
its
newly
analogues
screened
in
vitro
for
their
antibacterial
activity
against
two
Gram-positive
bacteria,
Staphylococcus
aureus
Listeria
monocytogenes;
Gram-negative
Salmonella
thyphimurium
Pseudomonas
aeruginosa.
Attractive
results
obtained
notably
L.
monocytogenes.
Compounds
18d,
18g
18h
exhibited
highest
when
compared
other
compounds
tested
pathogenic
bacterial
strains.
Molecular
docking
study
was
performed
to
explore
binding
mode
most
active
derivatives
target
protein
Results
showed
importance
both
hydrogen
bonding
hydrophobic
interactions
are
favor
experimental
data.
Phytotherapy Research,
Год журнала:
2023,
Номер
38(1), С. 131 - 146
Опубликована: Окт. 11, 2023
Neuroblastoma
and
glioblastoma
are
primary
malignant
tumors
of
the
nervous
system,
with
frequent
relapse
limited
clinical
therapeutic
drugs.
The
failure
their
treatment
is
due
to
tumor
cells
exhibiting
cancer
stem-like
(CSLCs)
properties.
Octamer
binding
transcription
factor
4
(Oct4)
involved
in
mediating
CSLCs,
our
previous
work
found
that
Oct4-driven
reprogramming
astrocytes
into
induced
neural
stem
was
potentiated
continuous
sonic
hedgehog
(Shh)
stimulation.
In
this
study,
we
aimed
study
importance
Oct4
Shh
combination
stemness
properties
induction
neuroblastoma
cells,
evaluate
anti-stemness
effect
dauricine
(DAU),
a
natural
product
bis-benzylisoquinoline
alkaloid.
co-activation
on
evaluated
by
spheres
formation
model
flow
cytometry
analysis.
Then
effects
DAU
SH-SY5Y
T98-G
were
assessed
MTT,
colony
formation,
model.
acts
verified
using
Western
blotting,
so
on.
Mechanistic
studies
explored
siRNA
transfection
assay,
We
identified
effectively
improved
Oct4-mediated
generation
promoted
cell
growth,
resistance
apoptosis.
addition,
DAU,
product,
be
able
attenuate
Oct4/Shh
co-activated
induce
cycle
arrest
apoptosis
via
blocking
AKT/β-catenin
signaling
glioblastoma,
which
contributed
growth
inhibition
DAU.
summary,
results
indicated
may
served
as
potential
method
glioblastoma.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15232 - 15232
Опубликована: Окт. 16, 2023
Gonadotropin-releasing
hormone
(GnRH)
is
pivotal
in
regulating
human
reproduction
and
fertility
through
its
specific
receptors.
Among
these,
gonadotropin-releasing
receptor
type
I
(GnRHR
I),
which
a
member
of
the
G-protein-coupled
family,
expressed
on
surface
both
healthy
malignant
cells.
Its
presence
cancer
cells
has
positioned
this
as
primary
target
for
development
novel
anti-cancer
agents.
Moreover,
extensive
regulatory
functions
GnRH
have
underscored
decapeptide
prominent
vehicle
targeted
drug
delivery,
accomplished
design
appropriate
conjugates.
On
basis,
rationally
designed
series
anthraquinone/mitoxantrone-GnRH
conjugates
(con1-con8)
been
synthesized
herein.
Their
vitro
binding
affinities
range
from
0.06
to
3.42
nM,
with
six
them
(con2-con7)
demonstrating
higher
than
established
leuprolide
(0.64
nM).
mitoxantrone
based
conjugates,
con3
con7
show
highest
at
0.07
respectively,
while
disulfide
bond
present
found
be
readily
reduced
by
thioredoxin
(Trx)
system.
These
findings
are
promising
further
pharmacological
evaluation
prospect
performing
future
clinical
studies.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(33), С. 6727 - 6741
Опубликована: Янв. 1, 2024
Herein,
we
present
a
general
approach
for
synthesizing
pluramycin
hybrids,
which
are
analogous
to
the
pluramycinone
carbocyclic
skeleton.
This
method
involves
sequence
of
relay
ring-closing
enyne
metathesis,
Diels-Alder
and
oxidative
aromatization
reactions
synthesize
pluramycinone-sugar
hybrids.
As
part
our
ongoing
research,
have
successfully
synthesized
two
hybrid
analogues
by
carefully
monitoring
late-stage
steps,
depend
on
stereo-orientation
cycloadduct
at
C-4
center.
The
undesired
ring-opening
product
can
also
serve
as
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(38), С. 3009 - 3017
Опубликована: Авг. 20, 2024
:
Medicinal
herbs
have
been
utilized
in
the
treatment
of
various
pathologic
conditions,
including
neoplasms,
organ
fibrosis,
and
diabetes
mellitus.
However,
precise
pharmacological
actions
plant
miRNAs
animals
remain
to
be
fully
elucidated,
particularly
terms
their
therapeutic
efficacy
mechanism
action.
In
this
review,
some
important
from
foods
medicinal
are
presented.
Plant
exhibit
a
range
properties,
such
as
anti-cancer,
anti-fibrosis,
anti-viral,
anti-inflammatory
effects,
neuromodulation,
among
others.
These
results
not
only
demonstrated
cross-species
regulatory
effect,
but
also
suggested
that
bioactive
components.
This
shows
promising
prospect
for
used
drugs.
Here,
properties
underlying
mechanisms
highlighted,
which
can
provide
new
insights
clarifying
suggest
way
developing
