Brazilian Journal of Health Review,
Год журнала:
2023,
Номер
6(5), С. 23436 - 23457
Опубликована: Окт. 2, 2023
Introdução:
A
resistência
microbiana,
resultado
do
uso
indevido
de
antibióticos,
é
reconhecida
como
uma
das
principais
ameaças
à
saúde
global.
falta
opções
terapêuticas
eficazes
e
o
aumento
ônus
financeiro
são
consequências
preocupantes.
terapia
fotodinâmica
antimicrobiana
(aPDT)
surge
alternativa
promissora
aos
antibióticos.
Dentre
os
fotossensibilizadores
utilizados,
origem
natural
se
destacam
devido
a
sua
eficiência
baixa
toxicidade.
Objetivo:
Apresentar
um
panorama
recente
aplicação
no
combate
infecções
bacterianas.
Método:
Revisão
literatura
com
abordagem
qualitativa,
realizada
por
meio
levantamento
bibliográfico
na
plataforma
Web
of
Science
ano
2022
seguinte
descritor:
photosensitizer.
Resultados
Discussão:
Os
estudos
analisados
exploraram
naturais
para
fotoinativação
micro-organismos
patogênicos.
Diversos
foram
reportados
(riboflavina,
clorofilina,
curcumina),
bem
nanoplataformas
nanopartículas
aumentar
eficácia
dos
tratamentos.
resultados
obtidos
promissores,
demonstrando
aPDT
ferramenta
antimicrobina
capacidade
fotoinativar
bactérias,
inclusive
aquelas
resistentes
antibióticos
convencionais.
Conclusão:
(curcumina,
clorina
e6,
riboflavina,
entre
outros)
apresentam
excelente
biocompatibilidade
contra
vasta
família
microrganismos
Além
disso,
salientamos
necessidade
da
transposição
laboratoriais
prática
clínica.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(22)
Опубликована: Апрель 11, 2023
Owing
to
their
long
absorption
wavelengths,
high
molar
absorptivity,
and
tunable
photosensitivity,
phthalocyanines
have
been
widely
used
in
photodynamic
therapy
(PDT).
However,
still
face
the
drawbacks
of
poor
targeting,
"always-on"
photosensitizing
properties,
unsatisfactory
therapeutic
efficiency,
which
limit
wide
applications
biomedical
fields.
Thus,
new
design
strategies
such
as
modification
targeting
molecules,
formation
nanoparticles,
activating
photosensitizers
are
developed
improve
above
defects.
Notably,
recent
studies
shown
that
novel
not
only
fluorescence
imaging
PDT,
but
also
photoacoustic
imaging,
photothermal
sonodynamic
therapy,
therapy.
This
review
focuses
on
strategies,
biomedicine,
clinical
development
phthalocyanines,
providing
ideas
references
for
application
phthalocyanine,
so
promote
future
transformation
into
applications.
Nanomaterials,
Год журнала:
2024,
Номер
14(15), С. 1250 - 1250
Опубликована: Июль 25, 2024
Antimicrobial
resistance
(AMR)
presents
an
escalating
global
challenge
as
conventional
antibiotic
treatments
become
less
effective.
In
response,
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
promising
alternatives.
While
rooted
in
ancient
practices,
these
methods
evolved
with
modern
innovations,
particularly
through
the
integration
of
lasers,
refining
their
efficacy.
PDT
harnesses
photosensitizers
to
generate
reactive
oxygen
species
(ROS),
which
are
detrimental
microbial
cells,
whereas
PTT
relies
on
heat
induce
cellular
damage.
The
key
effectiveness
lies
utilization
photosensitizers,
especially
when
integrated
into
nano-
or
micron-scale
supports,
amplify
ROS
production
enhance
antimicrobial
activity.
Over
last
decade,
carbon
dots
(CDs)
a
highly
nanomaterial,
attracting
increasing
attention
owing
distinctive
properties
versatile
applications,
including
PTT.
They
can
not
only
function
but
also
synergistically
combine
other
overall
This
review
explores
recent
advancements
CDs,
underscoring
significance
potential
reshaping
advanced
therapeutics.
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 101 - 117
Опубликована: Янв. 18, 2024
The
photoreactions
of
selected
styrylpyridine
derivatives
to
the
corresponding
benzo[
c
]quinolizinium
ions
are
described.
It
is
shown
that
these
reactions
more
efficient
in
aqueous
solution
(97–44%)
than
organic
solvents
(78–20%
MeCN).
quinolizinium
bind
DNA
by
intercalation
with
binding
constants
6–11
×
10
4
M
−1
,
as
photometric
and
fluorimetric
titrations
well
CD-
LD-spectroscopic
analyses.
These
ligand–DNA
complexes
can
also
be
established
situ
upon
irradiation
styrylpyridines
formation
intercalator
directly
presence
DNA.
In
addition
DNA-binding
properties,
tested
operate
photosensitizers,
which
induce
damage
at
relative
low
concentrations
short
times,
even
under
anaerobic
conditions.
Investigations
mechanism
revealed
involvement
intermediate
hydroxyl
radicals
C-centered
radicals.
Under
aerobic
conditions,
singlet
oxygen
only
contributes
marginal
extent
damage.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 465 - 482
Опубликована: Янв. 1, 2025
Abstract:
Photodynamic
therapy
(PDT)
is
a
promising
noninvasive
tumor
treatment
modality
that
relies
on
generating
reactive
oxygen
species
(ROS)
and
requires
an
adequate
supply
to
the
target
tissue.
However,
hypoxia
common
feature
of
solid
tumors
profoundly
restricts
anti-tumor
efficacy
PDT.
In
recent
years,
scholars
have
focused
exploring
nanomaterial-based
strategies
for
supplementation
integrating
non-oxygen-consuming
approaches
overcome
hypoxic
limitations
Some
harnessed
photosynthetic
production
cyanobacteria
under
light
irradiation
engineered
them
as
carriers
photosensitizers
instead
inorganic
nanomaterials,
resulting
in
bacteria
(PSB)
attracting
significant
attention.
Recent
studies
shown
light-triggered
PSB
can
exhibit
additional
properties,
such
hydrogen
production,
ROS
generation,
photothermal
conversion,
facilitating
their
use
light-responsive
biomaterials
enhancing
Therefore,
understanding
provide
new
insights
ideas
future
research.
This
review
mainly
introduces
characteristics
research
PDT
enrich
our
knowledge
this
area.
Finally,
challenges
prospects
using
enhance
were
also
discussed.
Keywords:
bacteria,
PDT,
hypoxia,
cyanobacteria,
purple
PTT
Journal of Biophotonics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
ABSTRACT
Scientists
have
been
actively
investigating
novel
therapies
that
can
effectively
eradicate
cancer
cells
with
negligible
side
effects
in
normal
tissues
when
used
alone
or
a
combinatorial
approach.
Photodynamic
therapy
has
emerged
as
promising
non‐invasive
integrates
photosensitizer,
oxygen,
and
specific
wavelength
of
light
for
the
treatment
cancer.
Despite
encouraging
outcomes
yielded
by
PDT,
conventional
PSs
are
faced
longstanding
challenges
such
poor
water
solubility,
short
half‐life,
off‐target
toxicity.
Development
nanotherapeutics
shown
great
potential
overcoming
this
issue.
The
tumor
microenvironment
is
inherently
hypoxic,
promotes
resistance
to
it
oxygen‐dependent.
Photoactivated
chemotherapy,
an
oxygen‐independent
light‐based
therapy,
utilizes
chemotherapeutic
regimens
remain
inert
until
exposed
light,
allowing
target‐specific
activation
while
minimizing
Integration
these
techniques
improve
selectivity
yield
synergistic
cytotoxic
could
treatment.
Molecules,
Год журнала:
2023,
Номер
28(14), С. 5610 - 5610
Опубликована: Июль 24, 2023
Tumor
immunotherapy,
compared
with
other
treatment
strategies,
has
the
notable
advantage
of
a
long-term
therapeutic
effect
for
preventing
metastasis
and
recurrence
tumors,
thus
holding
great
potential
future
advanced
tumor
therapy.
However,
due
to
poor
water
solubility
immune
modulators
escape
properties
cells,
efficiency
immunotherapy
is
usually
significantly
reduced.
Cyclodextrin
(CD)
been
repeatedly
highlighted
be
probably
one
most
investigated
building
units
cancer
therapy
its
elegant
integration
an
internal
hydrophobic
hollow
cavity
external
hydrophilic
outer
surface.
The
application
CD
provides
new
opportunities
overcoming
aforementioned
obstacles.
there
are
few
published
reviews,
our
knowledge,
summarizing
use
immunotherapy.
For
this
purpose,
paper
comprehensive
summary
on
emphasis
role,
function,
reported
strategies
in
mediating
This
review
summarizes
research
progress
made
using
which
will
facilitate
generation
various
CD-based
immunotherapeutic
delivery
systems
superior
anticancer
efficacy.
