Rational Design of Quinoidal Conjugated Polymers for Photothermal Antibacterial Therapy
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
The
increasing
prevalence
of
antibiotic
resistance,
driven
by
the
overuse
and
misuse
conventional
antibiotics,
has
become
a
critical
public
health
concern.
Photothermal
antibacterial
therapy
(PTAT)
utilizes
heat
generated
photothermal
agents
under
light
exposure
to
inhibit
bacterial
growth
without
inducing
attracting
more
attention.
Quinoid
conjugated
polymers,
especially
para‐azaquinodimethane
(AQM)
polymer,
are
class
organic
semiconductors
known
for
efficient
π‐electron
delocalization,
near‐infrared
absorption,
narrow
bandgap,
showing
great
potential
in
application
reagents.
However,
current
AQM
polymers
face
challenges
related
their
solubility,
photostability,
biocompability.
In
this
study,
tetraglycol
is
introduced
onto
core
improving
drawbacks
resulting
polymers.
Two
with
different
electron
donor
(thiophene
2,2'‐bithiophene)
synthesized
evaluated
various
properties.
PAQMT
exhibited
superior
performance,
including
higher
extinction
coefficients,
improved
greater
stability
repeated
NIR
irradiation.
further
developed
into
nanoparticles
via
encapsulation,
excellent
colloidal
stability,
effective
inhibition
808
nm
light.
This
work
provides
new
strategy
properties
offers
opportunities
promoting
quinoidal
PTAT.
Язык: Английский
The glowing frontier: Carbon dots' journey for customized cancer treatments
Anqi Liang,
Jie Yang,
Xiao Zhu
и другие.
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106658 - 106658
Опубликована: Фев. 1, 2025
Язык: Английский
Green Carbon Dots: Synthesis, Properties, and Theranostic Applications
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106861 - 106861
Опубликована: Март 1, 2025
Язык: Английский
Application of carbon-based nanomaterials in Alzheimer's disease
Materials Horizons,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Alzheimer's
disease
(AD)
is
a
chronic,
progressive
neurodegenerative
disorder
marked
by
permanent
impairment
of
brain
function
across
the
whole
brain.
This
condition
results
in
deterioration
cognitive
patients
and
frequently
associated
with
psychological
symptoms
such
as
agitation
anxiety,
imposing
significant
burden
on
both
their
families.
Nanomaterials
possess
numerous
distinctive
physical
chemical
features
that
render
them
extensively
utilized.
In
biomedical
domain,
nanomaterials
can
be
utilized
for
prevention
therapy,
including
medication
delivery
systems,
biosensors,
tissue
engineering.
article
explores
etiology
potential
molecular
processes
AD,
well
application
carbon-based
diagnosis
treatment
AD.
Some
are
carbon
quantum
dots,
nanotubes,
graphene,
among
others.
These
materials
physicochemical
highly
promising
applications
biosensing,
drug
delivery,
neuroprotection,
photothermal
treatment.
addition,
this
review
explored
various
therapeutic
approaches
AD
terms
reducing
inflammation,
preventing
oxidative
damage,
inhibiting
Aβ
aggregation.
The
advent
nanotechnology
has
facilitated
development
novel
disease.
strategies
provide
early
diagnosis,
effective
intervention
neuroprotection
Язык: Английский
Progress on Carbon Dots with Intrinsic Bioactivities for Multimodal Theranostics
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Carbon
dots
(CDs)
with
intrinsic
bioactivities
are
candidates
for
bioimaging
and
disease
therapy
due
to
their
diverse
bioactivities,
high
biocompatibility,
multiple
functionalities
in
multimodal
theranostics.
It
is
a
multidisciplinary
research
hotspot
that
includes
biology,
physics,
materials
science,
chemistry.
This
progress
report
discusses
the
CDs
applications
The
relationship
between
synthesis
structure
of
summarized
analyzed
from
material
chemical
perspective.
including
anti‐tumor,
antibacterial,
anti‐inflammatory
etc.
discussed
biological
points
view.
Subsequently,
optical
electronic
properties
can
be
applied
biomedical
field
physical
Based
on
functional
review
CDs,
reviewed,
diagnosis
treatment,
activity,
Unlike
previous
reviews,
this
combines
disciplines
gain
more
comprehensive
understanding
mechanisms,
functions,
bioactivities.
Язык: Английский
NIR-induced antimicrobial efficacy of TPA-BOIMPY conjugate through photothermal and photodynamic synergy
Journal of Photochemistry and Photobiology A Chemistry,
Год журнала:
2024,
Номер
460, С. 116136 - 116136
Опубликована: Ноя. 12, 2024
Язык: Английский
Toxicological Assessment of 2-Hydroxychalcone-Mediated Photodynamic Therapy: Comparative In Vitro and In Vivo Approaches
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1523 - 1523
Опубликована: Ноя. 26, 2024
Background:
Photodynamic
therapy
(PDT)
is
a
treatment
modality
that
uses
light
to
activate
photosensitizing
agent,
destroying
target
cells.
The
growing
awareness
of
the
necessity
reduce
or
eliminate
use
mammals
in
research
has
prompted
search
for
safer
toxicity
testing
models
aligned
with
new
global
guidelines
and
compliant
relevant
regulations.
Objective:
objective
this
study
was
assess
impact
PDT
on
alternative
mammals,
including
vitro
three-dimensional
(3D)
cultures
vivo,
invertebrate
animals,
utilizing
potent
photosensitizer,
2-hydroxychalcone.
Methods:
Cytotoxicity
assessed
two
cellular
models:
monolayer
(2D)
3D.
For
purpose,
spheroids
cell
lines,
primary
dermal
fibroblasts
(HDFa)
adult
human
epidermal
keratinocytes
(HaCat),
were
developed
characterized
following
criteria
viability,
shape,
diameter,
number
survival
percentages
Caenorhabditis
elegans
Galleria
mellonella
evaluated
at
1
7
days,
respectively.
Results:
findings
indicated
all
platforms
are
appropriate
investigating
toxicity.
Furthermore,
2-hydroxychalcone
demonstrated
low
absence
when
mediated
by
across
range
(2D
3D
cultures)
vivo
(invertebrate
animal
models,
G.
C.
elegans)
models.
Conclusion:
There
strong
correlation
between
tests,
similar
results,
particularly
elegans,
where
concentration
50%
viability
approximately
100
µg/mL.
Язык: Английский