Functional constituents of Colchicum lingulatum Boiss. & Spruner subsp. Rigescens K. Perss. Extracts and their biological activities with different perspectives

Food Bioscience, Год журнала: 2024, Номер 60, С. 104496 - 104496

Опубликована: Июнь 6, 2024

Язык: Английский

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Incorporating the HPLC‐ESI‐Q‐TOF‐MS profiles with the biochemical properties of eight Salvia species

eFood, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 2, 2025

Abstract Salvia , a widely recognized genus globally esteemed for its traditional and medicinal applications, prompted our investigation into the methanol water extracts of eight species native to Turkey. These included S. aucheri, candidissima, divaricata, virgata, multicaulis, palestina, trichoclada cerino‐pruinosa . Our study aimed assess their biological properties chemical composition. Utilizing HPLC‐ESI‐Q‐TOF‐MS, we identified constituents in extracts, while antioxidant (radical quenching, reducing power, metal chelating) enzyme inhibitory (amylase, glucosidase, tyrosinase, cholinesterase) activities were evaluated activities. One hundred thirty‐one compounds characterized tested extracts. Although many belonging different families identified, main all rosmarinic sagerinic acids, along with several salvianolic acid isomers. Notably, displayed superior overall, exhibiting highest activity among them, except chelating. Similar test results, more active than inhibition tests. Multivariate analysis further highlighted distinctiveness extract In conclusion, findings underscore biopharmaceutical potential species, suggesting significance as sources bioactive agents health‐promoting applications.

Язык: Английский

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Comparative GC-MS Analysis of Fresh and Dried Curcuma Essential Oils with Insights into Their Antioxidant and Enzyme Inhibitory Activities

Plants, Год журнала: 2023, Номер 12(9), С. 1785 - 1785

Опубликована: Апрель 27, 2023

Species belonging to the Zingiberaceae family are of high nutritional, industrial, and medicinal values. In this study, we investigated effect processing steps (fresh vs. dried milled rhizomes) extraction methodologies (hydrodistillation hexane extraction) curcuma essential oil on its chemical content (using GC-MS analysis), antioxidant behavior in vitro assays such as DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, metal chelation), enzyme inhibitory activities (on tyrosinase, acetylcholinesterase, butylcholinesterase, α-amylase, α-glucosidase) supported by multivariate analysis, silico studies, molecular dynamics. The investigations revealed a degree similarity profile fresh hydrodistilled hexane-extracted oils with tumerone curlone being major metabolites. techniques affected concentrations other minor constituents terpinolene, caryophylla-4(12), 8(13)-dien-5α-ol, neo-intermedeol, which were almost exclusively detected oil; however, zingiberene β-sesquiphellandrene predominant oil. rhizomes, contents significantly reduced, former only while latter was doubly concentrated hexane-derived Constituents D-limonene caryophyllene oxide represented ca. 29% oil, ar-turmerone oils, representing 16% 26% composition, respectively. These variations have subsequently properties activities. showed that hydrophobic interactions hydrogen bonding characteristic binding modes bioactive metabolites their respective targets. Molecular dynamics stability ligand-target complex over time. From current study conclude best radical scavenging properties, rhizomes general display better activity regardless technique.

Язык: Английский

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Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica

Plants, Год журнала: 2023, Номер 12(15), С. 2785 - 2785

Опубликована: Июль 27, 2023

Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. italica is a medicinal plant traditionally used for its analgesic effects, in present study, phytochemical composition biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, water extracts aerial parts were investigated determining phenolic composition, antioxidant anti-inflammatory isolated mouse colon specimens exposed lipopolysaccharide (LPS). Polar richest terms compounds, especially rosmarinic acid. In parallel, also most effective as scavenging/reducing enzyme inhibition agents, towards cholinesterases α-glucosidase, inhibiting LPS-induced cyclooxygenase-2 (COX-2) tumor necrosis factor α (TNFα) gene expression colon. This poses basis future vivo investigations confirming protective polar N. against inflammatory bowel diseases.

Язык: Английский

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Essential Oils Composition and Biological Activity of Chamaecyparis obtusa, Chrysopogon nigritanus and Lavandula coronopifolia Grown Wild in Sudan

Molecules, Год журнала: 2023, Номер 28(3), С. 1005 - 1005

Опубликована: Янв. 19, 2023

Generally, there are scant data about the constituents and eventually biological activity of essential oils (EOs) from aromatic plants that grow naturally in Sudan. The present study aimed to determine chemical composition, antioxidant enzyme inhibitory activities EO extracted fruit Chamaecyparis obtusa (Siebold Zucc.) Endl. (family Cupressaceae), root Chrysopogon nigritanus (Benth.) Veldkampis Poaceae) aerial part Lavandula coronopifolia Poir Lamiaceae). C. contained only monoterpenes, mainly hydrogenated ones, with α-pinene (69.07%) as major component. Oxygenated sesquiterpenes comprised highest content cedr-8-en-15-ol (28.69%) constituent while parts L. both monoterpenes oxygenated monoterpene lavandulol (26.56%) dominant compounds. significantly displayed (p < 0.05) anti-DPPH radical, Fe3+- Cu2+-reducing metal-chelating activities, exerted best anti-ABTS radical total activity. two EOs exhibited anti-acetylcholinesterase -butyrylcholinesterase respectively, was oil show a considerable effect against tyrosinase α-glucosidase enzymes. In conclusion, these three could be natural agents promising functional properties for food, cosmetics, pharmaceutical applications.

Язык: Английский

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A Comparative Study on UHPLC-HRMS Profiles and Biological Activities of Inula sarana Different Extracts and Its Beta-Cyclodextrin Complex: Effective Insights for Novel Applications

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1842 - 1842

Опубликована: Окт. 10, 2023

Within this particular framework, the extracts obtained from Inula sarana using a variety of solvents, included n-hexane, ethyl acetate, dichloromethane (DCM), 70% ethanol, and water. The DCM were then subjected to specific method for their incorporation into β-cyclodextrin (β-CD). establishment complex formation was validated through utilization scanning electron microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR). identification phytochemical components executed UHPLC-HRMS. Furthermore, total phenolic flavonoid content evaluated Folin-Ciocalteu assay AlCl3 method. Subsequently, determination antioxidant capacity conducted utilizing DPPH, ABTS, CUPRAC, Frap, PBD, MCA assays. enzyme inhibitory activities samples (extracts β-CD complexes) also examined by AChE, BChE, tyrosinase, α-glucosidase, α-amylase. findings indicated that water ethanol contained highest content. One hundred fourteen bioactive compounds identified UHPLC-HRMS analysis. This study unveiled substantial array flavonoids, acid-hexosides caffeoylhexaric acids within I. sarana, marking initial in context. Among various tested, extract stood out due its high (jaceosidin, cirsiliol, eupatilin) hydroxybenzoic hydroxycinnamic acid hexosides. displayed notably enhanced activity, with FRAP test values 106.50 mg TE/g dry extract, 224.31 110.40 TE/g, respectively. However, generally lower than those pure extracts, an observation warranting significant consideration. In terms inhibition exhibited higher effects on α-glucosidase. Conversely, n-hexane stronger activity against BChE. acetate demonstrated elevated amylase activity. noteworthy observation, while minimal or negatable enzymes.

Язык: Английский

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Helianthemum oelandicum subsp. incanum and Fumana thymifolia: Characterization of LC-ESI-QTOF-MS profiles and their biological activities based on plant parts and extraction solvents.

Kuwait Journal of Science, Год журнала: 2025, Номер unknown, С. 100378 - 100378

Опубликована: Янв. 1, 2025

Язык: Английский

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Oregano Young Plants Cultured at Low Temperature Reveal an Enhanced Healing Effect of Their Extracts: Anatomical, Physiological and Cytotoxicity Approach

Metabolites, Год журнала: 2025, Номер 15(2), С. 103 - 103

Опубликована: Фев. 7, 2025

The germination and early development of Origanum vulgare L. subsp. hirtum (Link) Ietswaart (Greek oregano) were studied to assess the plant's response different temperatures. After germination, seedlings cultivated in control (25 °C) cold (15 chambers with standard growth parameters. Comparative analyses plant morphology leaf anatomy conducted identify structural modifications induced by Physiological evaluations, including photosynthetic pigment measurements, phenolic content, antioxidant activity, performed differences between plants grown under two temperature conditions. Methanolic extracts from leaves tested for cytotoxicity on MCF-7 breast adenocarcinoma cells SH-SY5Y neuroblastoma cells, as well nine microbial strains. Additionally, biomarkers affected changes determined using LC-HRMS/MS analysis. revealed distinct physiological methanolic at 15 °C exhibited notably higher cytotoxic activity both cell lines but demonstrated no against results highlight influence low enhancing bioactive properties Greek oregano. findings provide valuable insights into environmental adaptability oregano, demonstrating impact its properties. therapeutic potential cultured is imprinted absence any

Язык: Английский

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PRODUCTION AND CHARACTERIZATION OF BACTERIAL CELLULOSE BIOCOMPOSITES BASED ON THYMUS SIPYLEUS BOISS. EXTRACT

Mühendislik Bilimleri ve Tasarım Dergisi, Год журнала: 2025, Номер 13(1), С. 165 - 176

Опубликована: Март 19, 2025

The aim of this study was to improve the antibacterial properties bacterial cellulose (BC) produced by ex situ modification in Kombucha culture medium. Bioactive methanol extract from plant Thymus sipyleus Boiss. added BC obtain a bioactive and cost-effective biocomposite. SEM FTIR analyses confirmed nanofibers, porous structure chemical bonding with nanofibers revealed that biocomposites were successfully produced. A significant decrease water retention swelling behavior observed biocomposites. activity determined according AATC100-2004 method. bactericidal activities compared those gram-positive bacteria Staphylococcus aureus ATCC 25923 gram-negative Escherichia coli 25922. Biocomposite T010 (0.10% extract) showed strong activity, reducing E. 84.6% S. 97.54%. results show T. can be used as an effective agent at appropriate concentrations biocomposite has excellent properties.

Язык: Английский

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Natural Products from the Mediterranean Area as Wound Healing Agents—In Vitro Studies: A Systematic Review

Antioxidants, Год журнала: 2025, Номер 14(4), С. 484 - 484

Опубликована: Апрель 17, 2025

Wound healing is a process that happens when lost tissue replenishes. For this process, both protective elements and wound accelerating factors are required. In recent years, the search for natural products promote faster prevent adverse effects has gained momentum. This systematic review, adhering to PRISMA (Preferred Reporting Items Systematic reviews Meta-Analyses) criteria, of products, with focus on from Mediterranean region. study sourced PubMed Scopus databases eligible articles publications over last six years. Due information volume, only in vitro studies were included review. The criteria set concluded 28 included. These showed many found have been studied treatment wounds. effect seems be related dose, type wounded tissue, application time. Moreover, half additionally tested shown antioxidant activity through DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), FRAP (Ferric Reducing Antioxidant Power) assays.

Язык: Английский

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