Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 30, 2023
Abstract
In
photothermal
therapy
(PTT),
the
conversion
of
second
near-infrared
(NIR-II)
window
allows
deeper
penetration
and
higher
laser
irradiance,
is
considered
a
promising
therapeutic
strategy
for
deep
tissues.
Since
lung
cancer
remains
leading
cause
cancer-related
deaths
worldwide,
despite
numerous
treatment
options,
we
aimed
to
develop
an
improved
bionic
nanotheranostic
combined
imaging
cancer.
We
gold
nanobipyramid
(Au
NBP)
as
agent
MnO
2
magnetic-resonance
enhancer
produce
core/shell
structures
(Au@MnO
;
AM)
modified
their
surfaces
with
homologous
cancer-cell
plasma
membranes
(PM)
enable
tumor
targeting.
The
performance
resulting
Au@MnO
@PM
(AMP)
was
evaluated
in
vitro
vivo.
AMP
exhibits
properties
under
NIR-II
irradiation
has
multimodal
in-vitro
functions.
enables
computed
tomography
(CT),
(PTI),
magnetic
resonance
(MRI)
tumors.
particular,
exhibited
remarkable
PTT
effect
on
cells
inhibited
cell
growth
1064
nm
vivo,
no
significant
systemic
toxicity.
This
study
achieved
guided
by
imaging,
thereby
demonstrating
novel
use
nanoparticles
irradiation.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 5651 - 5670
Опубликована: Окт. 1, 2023
Improving
the
treatment
of
triple-negative
breast
cancer
(TNBC)
is
a
serious
challenge
today.
The
primary
objective
this
study
was
to
construct
MUC1-C
shRNA@
Fe3O4
magnetic
nanoparticles
(MNPs)
and
investigate
their
potential
therapeutic
benefits
in
alternating
fields
(AMF)
on
TNBC.Firstly,
we
verified
high
expression
MUC1
TNBC
synthesized
specific
shRNA
plasmids
(MUC1-C
shRNA).
Then,
prepared
characterized
shRNA@Fe3O4
MNPs
confirmed
gene
silencing
effect
magneto-thermal
conversion
ability
AMF.
Moreover,
inhibitory
effects
vitro
vivo
were
observed
as
well
biosafety.
Finally,
protein
levels
BCL-2-associated
X
(Bax),
cleaved-caspase3,
glutathione
peroxidase
inhibitor
4
(GPX4),
nuclear
factor
erythroid
2-related
2
(NRF2),
ferritin
heavy
chain
1
(FTH1)
cells
tissues
examined,
it
speculated
that
apoptosis
ferroptosis
involved
synergistic
treatment.MUC1-C
have
size
~75
nm,
with
an
encapsulation
rate
(29.78±0.63)
%,
showing
excellent
therapy
hyperthermia
functions.
Under
constant
AMF
(3Kw)
set
concentration
(200µg
mL-1),
could
be
rapidly
warmed
up
within
20
minutes
stabilized
at
about
43
°C.
It
uptaken
by
through
endocytosis
significantly
inhibit
proliferation
migration,
growth
inhibition
79.22%
for
tumors.
After
treatment,
GPX4,
NRF2,
FTH1
tumor
suppressed,
while
Bax
cleaved-caspase3
increased.
As
key
measures,
therapy,
shown
strategy,
combined
index
(q
index)
1.23.In
conclusion,
developed
functions,
which
satisfactory
without
significant
side
effects.
This
provides
option
precision
TNBC.
Nanoscale,
Год журнала:
2024,
Номер
16(12), С. 6095 - 6108
Опубликована: Янв. 1, 2024
In
this
study,
a
novel
diagnostic-therapeutic
integrated
nanoplatform
(named
AMP)
was
developed
for
multimodal
imaging-guided
near-infrared
(NIR-II)
second
window
photothermal
therapy
cancer.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Март 10, 2025
Cancer
remains
a
significant
global
health
challenge,
driving
the
search
for
innovative
treatments.
Photothermal
therapy
(PTT)
has
emerged
as
promising
approach,
using
photothermal
agents
to
convert
near-infrared
(NIR)
light
into
heat
tumor
ablation.
Among
these
agents,
nano-molybdenum
oxide,
particularly
non-stoichiometric
MoO3-x
(0
<
x
1),
stands
out
due
its
unique
defect
structure,
strong
NIR
absorption,
high
conversion
efficiency
(PCE),
and
pH-responsive
degradation.
This
review
summarized
recent
advancements
in
oxide
PTT,
covering
classification,
synthesis,
surface
modification,
tumor-targeting
mechanisms.
Subsequently,
we
explored
applications
PTT
combination
therapies,
evaluated
biocompatibility
toxicity,
discussed
current
achievements,
challenges,
future
perspectives
cancer
treatment.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 4, 2024
Breast
cancer
is
among
the
most
prevalent
tumors
worldwide.
In
this
study,
in-situ
forming
implants
(ISFIs)
containing
rosuvastatin
calcium
were
prepared
using
three
types
of
poly
(D,
L-lactic-co-glycolic
acid)
(PLGA),
namely,
PLGA
50/50
with
ester
terminal
and
75/25
or
acid
terminal.
Additionally,
polydimethylsiloxane
(PDMS)
was
added
in
concentrations
0,
10,
20,
30%
w/v
to
accelerate
matrix
formation.
The
ISFIs
characterized
for
their
rheological
behaviors,
rate
formation,
in-vitro
drug
release.
All
formulations
revealed
a
Newtonian
flow
formation
between
0.017
0.059
mm/min.
Generally,
increasing
concentration
PDMS
increased
rate.
implants’
release
efficiency
values
ranged
46.39
89.75%.
ISFI
selected
further
testing,
as
it
has
highest
promising
value.
Copper-selenium
nanoparticles
two
different
particle
sizes
(560
383
nm
CS1
CS2,
respectively)
loaded
into
formulation
enhance
its
anticancer
activity.
unloaded
copper-selenium
evaluated
antibacterial
activity,
against
Gram-positive
negative
microorganisms,
efficacy,
MCF-7
MDA-MB-231
cell
lines.
results
confirmed
potency
cells
synergistic
effect
when
smaller
nanoparticles.
This
holds
considerable
potential
efficient
breast
therapy.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 11, 2024
Abstract
The
cryopreservation
and
transplantation
of
ovarian
tissue
underscore
its
paramount
importance
in
safeguarding
reproductive
capacity
ameliorating
disorders.
However,
challenges
persist
(OTC-T),
including
the
risk
damage
dysfunction.
Consequently,
there
has
been
a
compelling
exploration
into
realm
nanoregulators
to
refine
enhance
these
procedures.
This
review
embarks
on
meticulous
examination
intricate
anatomical
structure
ovary
microenvironment,
thereby
establishing
robust
groundwork
for
development
nanomodulators.
It
systematically
categorizes
delves
deeply
their
functions
mechanisms,
meticulously
tailored
optimizing
transplantation.
Furthermore,
imparts
valuable
insights
practical
applications
obstacles
encountered
clinical
settings
associated
with
OTC-T.
Moreover,
advocates
utilization
microbially
derived
nanomodulators
as
potent
therapeutic
intervention
cryopreservation.
progression
approaches
holds
promise
seamlessly
integrating
OTC-T
practices,
heralding
new
era
expansive
auspicious
prospects
this
pivotal
domain.
Graphical
Breast
cancer
is
one
of
the
leading
causes
death
among
women
globally,
making
its
diagnosis
and
treatment
challenging.
The
use
nanotechnology
for
an
emerging
area
research.
To
address
this
issue,
multiwalled
carbon
nanotubes
(MWCNTs)
were
ligand
exchanged
with
butyric
acid
(BA)
to
gain
hydrophilic
character.
successful
functionalization
was
confirmed
by
FTIR
spectroscopy.
Surface
morphology
changes
observed
using
SEM,
while
TEM
structural
integrity
MWCNTs
after
functionalization.
Particle
size,
zeta
potential,
UV
spectroscopy
also
performed
further
characterize
nanoparticles.
breast
aptamer
specific
Mucin-1
(MUC-1)
then
conjugated
functionalized
MWCNTs.
These
successfully
targeted
cells
(MDA-MB-231)
as
examined
cellular
uptake
studies
exhibited
a
reduction
in
cancer-induced
inflammation,
evidenced
gene
transcription
(qPCR)
protein
expression
(immunoblotting)
levels.
Immunoblot
confocal-based
immunofluorescence
assay
(IFA)
indicated
ability
CNTs
induce
photothermal
cell
MDA-MB-231
cells.
Upon
imaging,
effectively
visualized
due
MWCNTs'
act
magnetic
resonance
imaging
(MRI)
contrast
agents.
Additionally,
demonstrated
capabilities
eliminate
bound
Collectively,
our
findings
pave
way
developing
aptamer-labeled
viable
"theranostic
alternatives"
treatment.
