Advances in fecal microbiota transplantation for the treatment of diabetes mellitus DOI Creative Commons
Juan Zhang, Honggang Wang, Ying Liu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Апрель 10, 2024

Diabetes mellitus (DM) refers to a group of chronic diseases with global prevalence, characterized by persistent hyperglycemia resulting from various etiologies. DM can harm organ systems and lead acute or complications, which severely endanger human well-being. Traditional treatment mainly involves controlling blood sugar levels through replacement therapy drugs insulin; however, some patients still find satisfactory curative effect difficult achieve. Extensive research has demonstrated close correlation between enteric dysbacteriosis the pathogenesis types DM, paving way for novel therapeutic approaches targeting gut microbiota manage DM. Fecal transplantation (FMT), method re-establishing intestinal microbiome balance, offers new possibilities treating diabetes. This article provides comprehensive review microbiota, as well current advancements in FMT using an illustrative example. study aims offer perspectives establish theoretical foundation clinical diagnosis management

Язык: Английский

Caco2/HT-29 In Vitro Cell Co-Culture: Barrier Integrity, Permeability, and Tight Junctions’ Composition During Progressive Passages of Parental Cells DOI Creative Commons
Elena Donetti, Paola Bendinelli, Margherita Correnti

и другие.

Biology, Год журнала: 2025, Номер 14(3), С. 267 - 267

Опубликована: Март 6, 2025

Epithelial linings are crucial for the maintenance of physiological barriers. The intestinal epithelial barrier (IEB) consists enterocytes through tight junctions and mucus-secreting cells can undergo modifications throughout life. To reproduce as closely possible IEB main features over time, in vitro co-cultures Caco2/HT-29 70/30 formed by parental Caco2 HT-29 sub-cultivated more than 40 passages were set up. measurements transepithelial electrical resistance (TEER) identified two populations: TEER (PC) with values > 50 Ωcm2 fewer passages, leaky (LC) < passages. In LC, paracellular permeability increased parallel. By immunofluorescence Western blot analysis, an increase claudin 2 was observed LC vs. PC, no differences occludin expression. MUC-2 immunoreactivity stronger PC LC. also showed enhanced vulnerability to TNFα+IFN-γ. These results morpho-functional reported human leaky/aged gut support usefulness our cell model studying molecular processes underlying these testing drug/nutraceutical treatments ameliorate aging.

Язык: Английский

Процитировано

1
Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease DOI Open Access
Curtis L. Gabriel, Jane F. Ferguson

Circulation Research, Год журнала: 2023, Номер 132(12), С. 1674 - 1691

Опубликована: Июнь 8, 2023

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction underlies the leading causes of morbidity mortality, both within United States worldwide. Commensal microbiota are implicated in development cardiometabolic disease. Evidence suggests that microbiome is relatively variable during infancy early childhood, becoming more fixed later childhood adulthood. Effects microbiota, development, life, may induce changes host metabolism modulate risk mechanisms predispose toward In this review, we summarize factors influence gut composition function life explore how microbial throughout life. We highlight limitations current methodology approaches outline state-of-the-art advances, which improving research building refined diagnosis treatment options microbiome-targeted therapies.

Язык: Английский

Процитировано

21
Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives DOI
Sonal Datta, Diwakar Aggarwal, Nirmala Sehrawat

и другие.

Phytomedicine, Год журнала: 2023, Номер 121, С. 155100 - 155100

Опубликована: Сен. 18, 2023

Язык: Английский

Процитировано

20
Population-specific differences in the human microbiome: Factors defining the diversity DOI Creative Commons
Priyanka Govender, Meenu Ghai

Gene, Год журнала: 2024, Номер 933, С. 148923 - 148923

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

6
Systematic Review of Probiotics and Their Potential for Developing Functional Nondairy Foods DOI Creative Commons
Ricardo S. Alemán,

Ajitesh Yadav

Applied Microbiology, Год журнала: 2023, Номер 4(1), С. 47 - 69

Опубликована: Дек. 26, 2023

The gastrointestinal tract is an environment that hosts various microorganisms, including pathogens. Generally, pathogenic bacteria enter the host body through food and tract. These can colonize or infiltrate cells tissues, causing infectious diseases. In recent years, protective role of probiotic against pathogens has been carefully investigated. Probiotics have found to modulate intestinal microbial flora play a significant in tract’s function, especially by inhibiting growth bacteria. However, mechanism action probiotics yet be sufficiently proven recognized. Several important mechanisms support antagonistic effects on which achieved, for example, production different antimicrobial compounds, such as bacteriocins, organic acids, antibiotics, proteins, exopolysaccharides; mucosal barriers with mucosa binding blockers; competition nutrient uptake; strengthening immune system. Accordingly, this review summarizes studies examined their beneficial preventing bacterial improving functions. Comprehending allows selection appropriate strains specific applications dysfunction.

Язык: Английский

Процитировано

13
Recent advances in measuring the effects of diet on gastrointestinal physiology: Probing the “leaky gut” and application of real‐time ultrasound DOI Creative Commons
Tamara Mogilevski, Giovanni Maconi, Peter R. Gibson

и другие.

JGH Open, Год журнала: 2024, Номер 8(7)

Опубликована: Июль 1, 2024

Abstract There is a large pool of ideas in both mainstream and non‐mainstream medicine on how diet can be manipulated order to treat or prevent illnesses. Despite this, our understanding specific changes influence the structure function gastrointestinal tract limited. This review aims describe two areas that might provide key information integrity tract. First, demystifying “leaky gut syndrome” requires rational application interpretation tests intestinal barrier function. Multiple ways measuring have been described, but inherent difficulties translation from animal studies humans created misinterpretations misconceptions. The intrinsic nature dynamic. seldom considered assessment. To adequately understand effects dietary interventions function, background different regions dynamic responses stressors (such as psychological stress) should assessed minimum. Second, ultrasound, which now established assessment monitoring inflammatory bowel disease, has hitherto poorly evaluated assessing real‐time novel aspects patients with disorders gut‐brain interaction. In conclusion, more complete functional structural profile these investigations enable permit greater manipulation clinically relevant that, amongst other advantages, opportunities for personalized health care delivery.

Язык: Английский

Процитировано

5
Exopolysaccharides: Exploring their role as postbiotics DOI
S. Vijayalakshmi, Ramachandran Chelliah,

Kaliyan Barathikannan

и другие.

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 181 - 206

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Cutting-edge insights into the mechanistic understanding of plant-derived exosome-like nanoparticles: Implications for intestinal homeostasis DOI
Xiyuan Liu,

Lihua Mei,

Jiaxin Wang

и другие.

Food Research International, Год журнала: 2025, Номер unknown, С. 116186 - 116186

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer DOI Creative Commons
Neil Daniel, Riccardo Farinella,

Flavia Belluomini

и другие.

Seminars in Cancer Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Pancreatic cancers have high mortality and rising incidence rates which may be related to unhealthy western-type dietary lifestyle patterns as well increasing body weights obesity rates. Recent data also suggest a role for the gut microbiome in development of pancreatic cancer. Here, we review experimental observational evidence roles oral, intratumoural microbiomes, impaired barrier function exposure inflammatory compounds metabolic dysfunction contributors disease with focus on ductal adenocarcinoma initiation progression. We highlight some emerging editing techniques currently being investigated context disease. Notably, while is significantly altered PDAC its precursor diseases, utility diagnostic prognostic tool hindered by lack reproducibility potential reverse causality case-control cohorts. Future research should emphasise longitudinal mechanistic studies integrating multi-omics unravel complex host-microbiome interactions. This will allow deeper aetiologic insights that can inform treatments guide public health recommendations.

Язык: Английский

Процитировано

0
Depression in Diarrhea-Predominant IBS Patients: Exploring the Link Between Gut Barrier Dysfunction and Erythrocyte Polyunsaturated Fatty Acid Levels DOI Open Access
Michele Linsalata, Laura Prospero, Antonia Ignazzi

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2483 - 2483

Опубликована: Апрель 5, 2025

Background: Patients with irritable bowel syndrome (IBS) often experience comorbid psychological conditions, notably depression and anxiety. Evidence suggests that these conditions are linked to gut barrier dysfunction, dysbiosis, chronic inflammation. All factors central IBS pathophysiology mood disturbances. Polyunsaturated fatty acids (PUFAs) play crucial roles in modulating inflammation depression. This study examined the associations among intestinal permeability, PUFA profiles, low-grade inflammation, severity patients diarrhea (IBS-D). Methods: Forty-three IBS-D (7 men, 36 women; 44.56 ± 1.52 years) were categorized into depressed (IBS-D(d+)) non-depressed (IBS-D(d-)) groups according scores on subscale of Symptom Checklist-90-Revised (SCL-90-R). Biomarkers small permeability (s-IP) assessed urine blood, alongside erythrocyte membrane composition, indices. Results: (d+) exhibited elevated s-IP altered metabolism compared their (d-) counterparts. Additionally, first group, omega-3 concentrations inversely correlated biomarkers, while omega-6/omega-3 ratio showed a positive correlation. Moreover, is significantly associated markers levels. Lastly, higher levels dysbiosis pro-inflammatory cytokines than patients. Conclusions: These findings highlight interplay between integrity depression, suggesting profiles could represent novel therapeutic targets for managing this population. was registered ClinicalTrials.gov (NCT03423069), date registration 30 January 2018.

Язык: Английский

Процитировано

0