Recent Advances in Catalytic Atroposelective Synthesis of Axially Chiral Quinazolinones

Catalysts, Год журнала: 2025, Номер 15(5), С. 426 - 426

Опубликована: Апрель 27, 2025

Quinazolinones, a class of nitrogen-containing heterocyclic compounds, occupy crucial position in medicinal chemistry and materials science due to their significant application potential. In recent years, the catalytic asymmetric synthesis axially chiral quinazolinones has emerged as prominent research area, driven by prospective applications development bioactive molecules, design ligands, fabrication functional materials. This review comprehensively summarizes advancements quinazolinones, with particular focus on construction strategies for three major structural types: C–N axis, N–N C–C axis. Key synthetic methodologies, including atroposelective halogenation, kinetic resolution, condensation–oxidation, photoredox deracemization, are discussed detail. addition, provides an in-depth analysis various systems, such peptide catalysis, enzymatic metal phosphoric acid others. Despite substantial progress made thus far, several challenges remain, expansion substrate scope, enhanced control over stereoselectivity, further exploration practical applications, drug discovery catalysis. These insights expected guide future towards novel strategies, diversification variants, comprehensive understanding biological activities functions. Ultimately, this will foster continued growth evolution rapidly advancing field.

Язык: Английский

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Design and synthesis of novel quinazolinone-based pyruvate kinase M2 activators as selective inhibitors of oral cancer cells

Journal of Molecular Structure, Год журнала: 2024, Номер 1304, С. 137595 - 137595

Опубликована: Янв. 24, 2024

Язык: Английский

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Exploring sustainable corrosion inhibition of copper in saline environment: An examination of hydroquinazolinones via experimental and ab initio DFT simulations

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(5), С. 105716 - 105716

Опубликована: Март 8, 2024

Copper's potential in various applications is constrained due to environmental degradation, particularly high-salinity environments, representing a sustainability concern. Herein, two novel hydroquinazolinones, namely 1-((4-hydroxynaphthalen-1-yl)methyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one (DQ-H) and 1-((4-hydroxynaphthalen-1-yl)methyl)-2-(p-tolyl)-2,3-dihydroquinazolin-4(1H)-one (DQ-CH3), were analyzed for their ability inhibit copper corrosion 3.5 % NaCl solution. The compounds, characterized by 1H 13C NMR, evaluated via potentiodynamic polarization curves, electrochemical impedance spectroscopy, weight loss measurements. Comprehensive analyses utilizing scanning electron microscopy, Fourier Transform Infrared, UV–vis spectroscopy have revealed insights into the surface morphology interactive nature of inhibitor molecules with surface. Our findings highlight formation strong, sustainable film on addition thereby exhibiting an enhanced resistance decreased double-layer capacitance. Both DQ-H DQ-CH3 demonstrated considerable inhibition effect, efficiencies 92 94 respectively, illustrating protection. Electrochemical (EIS) results indicated significant increase from 605.7 (blank) 9403 12861 Ω cm2, after DQ-CH3, respectively. Furthermore, adsorption attributes compounds Cu(1 1 1) examined using first-principles density functional theory simulation, revealing several covalent bonds formation. work aims contribute efforts materials science offering corrosion-protective solution that less harmful environment more efficient preserving copper's durability, saline environments.

Язык: Английский

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Synthesis of 8-methyl-2-phenylquinazolin-4(3H)-ones derived Schiff's bases: Spectroscopic properties, SAR, docking approaches and their anticancer and antimicrobial activity

Journal of Molecular Structure, Год журнала: 2024, Номер 1310, С. 138256 - 138256

Опубликована: Апрель 4, 2024

Язык: Английский

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Glutamic acid-catalyzed synthesis of dihydroquinazolinone: anticancer activity, electrochemical behavior, molecular docking, dynamics, simulations and drug-likeness studies

Research on Chemical Intermediates, Год журнала: 2024, Номер 50(7), С. 3271 - 3303

Опубликована: Май 27, 2024

Язык: Английский

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