International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141570 - 141570
Опубликована: Фев. 27, 2025
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 235, С. 123847 - 123847
Опубликована: Фев. 28, 2023
Язык: Английский
Процитировано
76
Gels, Год журнала: 2023, Номер 9(2), С. 138 - 138
Опубликована: Фев. 6, 2023
Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, remodeling stages. In order to realize comprehensive systematic wound management, appropriate treatment bio-adhesives are urgently needed. Hydrogel have excellent properties show unique remarkable advantages in the field of management. This review begins with detailed description design criteria functionalities ideal hydrogel for healing. Then, recent advances polysaccharide-based multifunctional bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, other polysaccharides, comprehensively discussed. Finally, current challenges future research directions proposed stimulate further exploration by researchers.
Язык: Английский
Процитировано
75
Advanced Industrial and Engineering Polymer Research, Год журнала: 2023, Номер 7(1), С. 79 - 99
Опубликована: Июль 19, 2023
Chitosan is obtained from chitin, which abundantly found in crustaceans and through various methods. The demineralization, deproteinization, discoloration, deacetylation of chitin produce chitosan consisting D-glucosamine N-acetyl units that are linked β-(1,4)-glycosidic linkages. has gained significant attention the biomedical field due to its unique properties such as abundance, renewability, non-toxic nature, antimicrobial activity, biodegradability, polyfunctionality. One key why it been heavily utilized field. To provide a comprehensive overview chitosan, this review discusses extraction based on source It also delves into chemical modifications nanocomposite development using natural synthetic materials. emphasizes multitude make an excellent choice for wide range applications. mechanisms antibacterial activity factors affecting activity. Additionally, highlights hemocompatibility, antioxidant anti-inflammation, other contribute suitability different applications, including wound dressing materials, drug delivery carriers, biosensing diagnostic devices, bone substitutes, bioimaging. While discussing some limitations concludes with future perspective developing multifunctional chitosan-based nanomaterials could potentially move laboratory clinical trials treating diseases.
Язык: Английский
Процитировано
70
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103267 - 103267
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
55
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124960 - 124960
Опубликована: Май 23, 2023
Язык: Английский
Процитировано
49
European Polymer Journal, Год журнала: 2024, Номер 210, С. 112983 - 112983
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
47
Polymers, Год журнала: 2024, Номер 16(3), С. 344 - 344
Опубликована: Янв. 26, 2024
Chitosan is a linear polyelectrolyte with active hydroxyl and amino groups that can be made into chitosan-based hydrogels by different cross-linking methods. Chitosan-based also have three-dimensional network of hydrogels, which accommodate large number aqueous solvents biofluids. CS, as an ideal drug-carrying material, effectively encapsulate protect drugs has the advantages being nontoxic, biocompatible, biodegradable. These make it material for preparation functional act wound dressings skin injuries. This review reports role in promoting repair context mechanisms involved injury repair. were found to promote at process stages. Various are discussed.
Язык: Английский
Процитировано
33
Gels, Год журнала: 2024, Номер 10(3), С. 188 - 188
Опубликована: Март 8, 2024
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements an ideal wound dressing, making them promising for care. These features include, among others, the ability to absorb and retain large amounts water capacity closely mimic native structures, such as extracellular matrix, facilitating cellular processes like proliferation differentiation. The polymers used in hydrogel formulations exhibit broad spectrum properties, allowing be classified into two main categories: natural collagen chitosan, synthetic polyurethane polyethylene glycol. This review offers comprehensive overview critical analysis key can constitute hydrogels, beginning with brief contextualization polymers. It delves their function, origin, chemical structure, highlighting sources extraction obtaining. Additionally, this encompasses intrinsic properties these roles healing process, accompanied, whenever available, by explanations underlying mechanisms action. also addresses limitations describes some studies on effectiveness isolated promoting skin regeneration healing. Subsequently, we briefly discuss application strategies hydrogels derived from potential promote process. achieved due role stimulation angiogenesis, example, or through incorporation substances growth factors drugs, antimicrobials, imparting new hydrogels. In addition substance incorporation, is related serve three-dimensional matrix cell culture, whether it involves loading cells recruiting site, where they proliferate scaffold form tissue. latter strategy presupposes biosensors real-time monitoring conditions, temperature pH. Future prospects then ultimately addressed. As far aware, manuscript represents first approach brings together critically analyzes fundamental aspects both constituting context cutaneous will foundational point future studies, aiming contribute development effective environmentally friendly dressing wounds.
Язык: Английский
Процитировано
30
Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122233 - 122233
Опубликована: Май 4, 2024
Язык: Английский
Процитировано
28
Materials, Год журнала: 2024, Номер 17(2), С. 278 - 278
Опубликована: Янв. 5, 2024
Effective wound treatment has become one of the most important challenges for healthcare as it continues to be leading causes death worldwide. Therefore, care technologies significantly evolved in order provide a holistic approach based on various designs functional dressings. Among them, hydrogels have been widely used due their biocompatibility and similarity extracellular matrix. The hydrogel formula offers control an optimal moisture level its ability absorb excess fluid from or release needed. Additionally, can successfully integrated with plethora biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing performance resulting composite healing applications. In this review, the-state-of-the-art discoveries related stimuli-responsive hydrogel-based dressings summarized, taking into account antimicrobial, anti-inflammatory, antioxidant, hemostatic properties, well other effects re-epithelialization, vascularization, restoration tissue) use.
Язык: Английский
Процитировано
22