International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141570 - 141570
Опубликована: Фев. 27, 2025
Язык: Английский
Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(11)
Опубликована: Фев. 24, 2024
Abstract Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing role minimally invasive therapeutic delivery, tissue repair, regeneration. The recent emergence nanomaterials has ushered a revolutionary transformation the field, which demonstrates tremendous potential targeted therapies, biological imaging, disease diagnostics. Consequently, integration advanced nanotechnology promises to trigger new revolution realm hydrogels. HMs loaded combine advantages both hydrogels nanomaterials, enables multifaceted functionalities such as efficient drug sustained release, therapy, lubrication, biochemical detection, medical biosensing monitoring, micro‐robotics. Here, this review comprehensively expounds upon commonly used classifications. Then, it provides comprehensive insights into raw materials preparation methods HMs. Besides, common strategies employed achieve nano‐micron combinations are summarized, latest applications these combined field elucidated. Finally, valuable future design development provided.
Язык: Английский
Процитировано
10
Starch - Stärke, Год журнала: 2024, Номер unknown
Опубликована: Июнь 20, 2024
Abstract Growing concerns about the harmful impact of synthetic polymers on environment and living organisms have shifted attention towards biopolymers which are environment‐friendly biocompatible. Biopolymers represent attractive sustainable biodegradable alternatives for replacing commercial polymers. Chitosan is one most prevalent available Earth. an alkaline cationic polymer, deacetylated form chitin. possesses excellent physicochemical properties such as biocompatibility, biodegradability, nontoxic, nonallergenic, biologically active molecules. During recent years, there has been a surge in demand chitosan various fields, however, due to poor water solubility mechanical properties, applications limited some extent. Strong inter intramolecular hydrogen bonds matrix make it highly crystalline, reducing its solubility. Chemical modification by technologies reported improve other characteristics, expanding application areas. Details chemical reactions involved focused this paper. The role chitin deacetylase enzyme discussed. This review aims provide insight into developments functionalization, development derivatives applications.
Язык: Английский
Процитировано
10
Gels, Год журнала: 2024, Номер 10(5), С. 295 - 295
Опубликована: Апрель 25, 2024
Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization drug encapsulation, transport, controlled release, complemented by biocompatibility, biodegradability, non-immunogenic nature. Stimuli-responsive hydrogels, also known smart have strictly regulated release patterns since they respond adapt based various external stimuli. Moreover, can imitate the intrinsic tissues’ mechanical, biological, physicochemical properties. These characteristics allow stimuli-responsive hydrogels provide cutting-edge, effective, safe treatment. Constant progress field necessitates an up-to-date summary of current trends breakthroughs biomedical application chitosan-based was aim this review. General data about sensitive ions, pH, redox potential, light, electric field, temperature, magnetic are recapitulated. Additionally, responsive multiple stimuli mentioned. Focusing multifaceted thoroughly described. The vast spectrum encompasses neurological disorders, tumors, wound healing, dermal infections. Available chitosan strongly support idea that approaches developing novel solutions worth improving. present paper constitutes valuable resource researchers practitioners currently field.
Язык: Английский
Процитировано
8
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1201 - 1201
Опубликована: Сен. 13, 2024
Chitosan is the most commonly investigated functional cationic biopolymer in a wide range of medical applications due to its promising properties such as biocompatibility, biodegradability, and bioadhesivity, well numerous bioactive properties. Within last three decades, chitosan derivatives have been biomaterials for drug vaccine delivery systems, besides their Due groups structure, it possible tailor systems with desired There has great interest application chitosan-based also prevention treatment infectious diseases, specifically antimicrobial, antiviral, immunostimulatory effects. In this review, recent diseases are reviewed, possibilities limitations regards technical regulatory aspects discussed. Finally, future perspectives on utilization biomaterial
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141570 - 141570
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
1