Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Abstract
Proteins
have
emerged
as
promising
therapeutics
in
oncology
due
to
their
great
specificity.
Many
treatment
strategies
are
developed
based
on
protein
biologics,
such
immunotherapy,
starvation
therapy,
and
pro‐apoptosis
while
some
biologics
entered
the
clinics.
However,
clinical
translation
is
severely
impeded
by
instability,
short
circulation
time,
poor
transmembrane
transportation,
immunogenicity.
Micro‐
nano‐particles‐based
drug
delivery
platforms
designed
solve
those
problems
enhance
therapeutic
efficacy.
This
review
first
summarizes
different
types
of
proteins
research
stages,
highlighting
administration
limitations.
Next,
various
micro‐
nano‐particles
described
demonstrate
how
they
can
overcome
The
potential
then
explored
efficacy
combinational
therapies.
Finally,
challenges
future
directions
carriers
discussed
for
optimized
delivery.
Organ-on-a-chip,
also
known
as
"tissue
chip,"
is
an
advanced
platform
based
on
microfluidic
systems
for
constructing
miniature
organ
models
in
vitro.
They
can
replicate
the
complex
physiological
and
pathological
responses
of
human
organs.
In
recent
years,
development
bone
joint-on-chip
platforms
aims
to
simulate
processes
occurring
bones
joints,
including
cell-cell
interactions,
interplay
various
biochemical
factors,
effects
mechanical
stimuli,
intricate
connections
between
multiple
future,
will
integrate
advantages
disciplines,
bringing
more
possibilities
exploring
disease
mechanisms,
drug
screening,
personalized
medicine.
This
review
explores
construction
application
Organ-on-a-chip
technology
joint
research,
proposes
a
modular
concept,
discusses
new
opportunities
future
challenges
platforms.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Effective
treatment
of
bone
diseases
is
quite
tricky
due
to
the
unique
nature
tissue
and
complexity
repair
process.
In
combination
with
biological
materials,
cells
factors
can
provide
a
highly
effective
safe
strategy
for
regeneration,
especially
based
on
these
multifunctional
hydrogel
interface
materials.
However,
itis
still
challenge
formulate
materials
fascinating
properties
(e.g.,
activity,
controllable
biodegradability,
mechanical
strength,
excellent
cell/tissue
adhesion,
release
properties)
their
clinical
applications
in
complex
processes.
this
review,
we
will
highlight
recent
advances
developing
functional
hydrogels.
We
then
discuss
barriers
producing
without
sacrificing
inherent
properties,
potential
cartilage
are
discussed.
Multifunctional
serve
as
fundamental
building
block
engineering.
Abstract
Hydrogel
microspheres
are
important
in
regenerative
medicine
and
tissue
engineering,
acting
as
cargos
of
cells,
drugs,
growth
factors,
bio‐inks
for
3D
printing,
medical
devices.
The
antimicrobial
anti‐inflammatory
characteristics
hydrogel
good
treating
injured
tissues.
However,
the
biological
properties
should
be
modified
optimal
treatment
various
body
parts
with
different
physiological
biochemical
environments.
In
addition,
specific
preparation
methods
required
to
produce
customized
shapes
sizes
clinical
applications.
Herein,
advances
biomedical
applications
reviewed.
Synthesis
precursor
solutions,
manufacturing
methods,
strategies
enhancing
functions
these
described.
involvement
bioactive
repair
is
also
discussed.
This
review
anticipates
fostering
more
insights
into
design,
production,
application
biomedicine.
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Апрель 7, 2025
Nitric
oxide
(NO)
is
essential
for
wound
healing,
promoting
angiogenesis
and
collagen
deposition.
This
study
investigates
a
novel
dual-matrix
nanocomposite
hydrogel
incorporating
S-nitrosoglutathione
(GSNO),
physiological
NO
donor,
to
enhance
cutaneous
healing.
GSNO
was
encapsulated
in
ammonio
methacrylate
copolymer
nanoparticles
embedded
an
alginate-based
matrix,
achieving
controlled
release.
GSNO-loaded
were
prepared
using
solvent
displacement
evaporation
methods,
resulting
spherical,
well-distributed
positively
charged
particles.
These
cross-linked
with
negatively
alginic
acid
form
hydrogel.
The
hydrophobic
protected
from
degradation,
while
the
hydrophilic
alginate
matrix
sustained
release
of
active
up
10
h,
haemostasis
maintaining
moist
environment.
exhibited
good
biocompatibility
human
fibroblasts
significantly
enhanced
repair
by
fibroblast
formation,
neovascularisation
deposition,
as
demonstrated
haematoxylin
eosin
staining
Masson's
trichrome
staining.
In
conclusion,
accelerated
healing
process
enhancing
offering
promising
strategy
improving
Vaccines,
Год журнала:
2025,
Номер
13(5), С. 469 - 469
Опубликована: Апрель 27, 2025
Background:
The
high
incidence
and
mortality
rates
of
cancer
have
kept
it
at
the
top
research
agenda
for
global
healthcare
industry,
as
well
put
serious
economic
pressure
on
families
society.
It
has
gradually
been
recognised
that
reducing
through
various
interventions
combining
prevention
treatment
are
key
to
alleviating
burden
cancer.
Methods:
Retrieve
summarize
literature
related
delivery
methods
tumor
vaccines,
investigate
whether
these
applied
clinically
or
used
in
clinical
trials.
Results:
there
a
variety
vaccine
development,
but
only
very
small
number
studies
able
make
strides
towards
implementing
clinic,
which
is
closely
linked
drawbacks
with
means
delivery.
Conclusions:
This
review
analyses
reasons
why
difficult
apply
clinic
from
point
view
method
rather
than
design
vaccine.
also
describes
some
not
yet
vaccines
and,
considering
this
conjunction
those
currently
purpose,
predicts
their
prospects
future
application.
