Опубликована: Янв. 1, 2024
Язык: Английский
In Silico Pharmacology, Год журнала: 2025, Номер 13(1)
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2023, Номер 8(37), С. 33514 - 33525
Опубликована: Сен. 7, 2023
Macrophage-mediated inflammation plays essential roles in multiple-organ injury. Sinensetin (SNS) at least exhibits anti-inflammation, antioxidant, and antitumor properties. However, the underlying mechanism of SNS-targeted macrophage-mediated remains elusive. In present study, our results showed that SNS suppressed lipopolysaccharide (LPS)-induced to ameliorate lung liver injuries. Mechanistically, significantly inhibited M1-type macrophage polarization its NLRP3 inflammasome formation decrease tumor necrosis factor α (TNFα) IL-6 expression, while increasing IL-10 expression. Moreover, interacted activated SIRT1 promote NRF2 target gene SOD2 transcription, which subsequently decreased LPS-induced inflammation. knockdown impaired effects on inhibition polarization, formation, NRF2/SOD2 signaling. Taken together, is a potential promising natural active ingredient inflammatory injury via activating SIRT1/NRF2/SOD2
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5756 - 5756
Опубликована: Май 25, 2024
Taxus × media, belonging to the genus of Taxaceae family, is a unique hybrid plant derived from natural crossbreeding between cuspidata and baccata. This distinctive variety inherits superior traits its parental species, exhibiting significant biological medicinal values. paper comprehensively analyzes media multiple dimensions, including cultivation overview, chemical composition, multifaceted applications in medical field. In terms constituents, this study delves into bioactive components abundant their pharmacological activities, highlighting importance value these components, paclitaxel, as lead compounds traditional medicine modern drug development. Regarding value, article primarily discusses potential combating tumors, antibacterial, anti-inflammatory, antioxidant treating diabetes. By synthesizing clinical research experimental data, elucidates mechanisms primary active preventing diseases. conclusion, demonstrates tremendous
Язык: Английский
Процитировано
2
Industrial Crops and Products, Год журнала: 2024, Номер 219, С. 118975 - 118975
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2023, Номер 28(6), С. 2774 - 2774
Опубликована: Март 19, 2023
The composition of volatile oils the leaf and stem Farfugium japonicum (L.) Kitamura were prepared by supercritical fluid extraction (SFE)-CO2. A total 47 40 compounds identified GC/MS analysis, respectively, only 13 coexisted. main constituent types in oil included alcohols (34.1%), hydrocarbons (24.1%), terpenoids (16.2%), benzenes (7.5%), fatty acids (4.9%). In oil, chiefly (18.8%), ketones (13.9%), (17.0%), (8.8%), phenolics (8.7%), steroids (8.6%), (8.0%), esters (5.7%). predominant 2-(1-cyclopent-1-enyl-1-methylethyl) cyclopentanone (11.7%), 1,2,3,4,5,6,7,8-octahydro- 9,10-dimethyl-anthracene (8.4%), 5-heptylresorcinol (6.5%), α-sitosterol (5.2%). Those mainly (E)-3-hexen-1-ol (13.7%) (Z)-3-hexen-1-ol (14.0%). This demonstrated a significant difference both oils. Further study showed that highest DPPH (1,1-diphenyl-2-pinylhydrazyl) ·OH free radical scavenging capacities at IC50 values 9.22 0.90 mg/mL, respectively. addition, they strongest antibacterial capacity against Gram-positive bacteria methicillin-sensitive Staphylococcus aureus (MSSA) methicillin-resistant (MRSA) minimum inhibitory concentration (MIC) 0.16 mg/mL. could be due to SFE-CO2 high accumulation benzenes, terpenoids, stem. particular, monoterpenes presented play special role these findings.
Язык: Английский
Процитировано
5
The American Journal of Chinese Medicine, Год журнала: 2024, Номер unknown, С. 1 - 29
Опубликована: Авг. 30, 2024
, a rare and protected genus predominantly distributed across the Northern Hemisphere's temperate regions, has garnered global attention due to its significant potential in medical research pharmaceutical development, bolstered by advancements cultivation techniques technology. This review primarily focuses on chemical constituents pharmacological activities of
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115555 - 115555
Опубликована: Сен. 28, 2023
A cytokine storm (CS) is a rapidly occurring, complex, and highly lethal systemic acute inflammatory response induced by pathogens other factors. Currently, no clinical therapeutic drugs are available with significant effect minimal side effects. Given the pathogenesis of CS, natural products have become important resources for bioactive agents in discovery anti-CS drugs. This study aimed to provide guidance preventing treating CS-related diseases reviewing identified inhibit CS recent years. comprehensive literature review was conducted on products, utilizing databases such as PubMed Web Science. The quality studies evaluated summarized further analysis. more than 30 types including 9 classes flavonoids, phenols, terpenoids, among others. In vivo vitro experiments demonstrated that these could effectively via nuclear factor kappa-B, mitogen-activated protein kinase, Mammalian target rapamycin (mTOR) signaling pathways. Moreover, enzyme inhibition assays revealed 20 chemical components had potential ACE2, 3CL-protease, papain-like protease activity. experimental results were obtained using advanced technologies biochips omics. Various compounds traditional Chinese medicine (TCM) extracts directly or indirectly occurrence, potentially serving effective diseases. may guide exploration effects biochemical mechanisms CS.
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2024, Номер 29(10), С. 2291 - 2291
Опубликована: Май 13, 2024
Taxus, as a globally prevalent evergreen tree, contains wealth of bioactive components that play crucial role in the pharmaceutical field. Taxus extracts, defined collection one or more compounds extracted from genus spp., have become significant focus modern cancer treatment research. This review article aims to delve into scientific background extracts and their considerable value It meticulously sifts through compares various advanced extraction techniques such supercritical extraction, ultrasound microwave-assisted solid-phase high-pressure pulsed electric field enzymatic assessing each technology’s advantages limitations across dimensions efficiency, purity, economic cost, operational time, environmental impact, with comprehensive analysis results presented table form. In area drug formulation design, this paper systematically discusses development strategies for solid, liquid, semi-solid dosage forms based on unique physicochemical properties intended medical uses, specific release characteristics, delving deeply selection excipients critical technical issues preparation process. Moreover, looks forward potential directions future research applications, emphasizing urgency importance continuously optimizing methods design enhance efficacy, reduce production costs, decrease burdens. provides set optimization schemes researchers other fields, promoting application sciences.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0