International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13381 - 13381
Опубликована: Авг. 29, 2023
Diabetes
mellitus
is
a
chronic
multifaceted
disease
with
multiple
potential
complications,
the
treatment
of
which
can
only
delay
and
prolong
terminal
stage
disease,
i.e.,
type
2
diabetes
(T2DM).
The
World
Health
Organization
predicts
that
will
be
seventh
leading
cause
death
by
2030.
Although
many
antidiabetic
medicines
have
been
successfully
developed
in
recent
years,
such
as
GLP-1
receptor
agonists
SGLT-2
inhibitors,
single-target
drugs
are
gradually
failing
to
meet
therapeutic
requirements
owing
individual
variability,
diversity
pathogenesis,
organismal
resistance.
Therefore,
there
remains
need
investigate
pathogenesis
T2DM
more
depth,
identify
targets,
provide
improved
glycemic
control
solutions.
This
review
presents
an
overview
mechanisms
action
development
latest
agents
targeting
years.
It
also
discusses
emerging
target-based
therapies
new
targets
emerged
within
last
three
aim
our
theoretical
basis
for
further
advancement
targeted
T2DM.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 28, 2024
Metabolic
diseases
and
their
complications
impose
health
economic
burdens
worldwide.
Evidence
from
past
experimental
studies
clinical
trials
suggests
our
body
may
have
the
ability
to
remember
metabolic
environment,
such
as
hyperglycemia
or
hyperlipidemia,
thus
leading
chronic
inflammatory
disorders
other
even
after
elimination
of
these
environments.
The
long-term
effects
that
aberrant
metabolism
on
been
summarized
memory
are
found
assume
a
crucial
role
in
states
disease.
Multiple
molecular
mechanisms
collectively
participate
management,
resulting
different
cellular
alterations
well
tissue
organ
dysfunctions,
culminating
disease
progression
affecting
offspring.
elucidation
expansion
concept
provides
more
comprehensive
insight
into
pathogenic
underlying
promises
be
new
target
detection
management.
Here,
we
retrace
history
relevant
research
summarize
its
salient
characteristics.
We
provide
detailed
discussion
by
which
involved
development
at
molecular,
cellular,
levels,
with
emphasis
impact
epigenetic
modulations.
Finally,
present
some
pivotal
findings
arguing
favor
targeting
develop
therapeutic
strategies
for
latest
reflections
consequences
implications
human
diseases.
Nutrients,
Год журнала:
2024,
Номер
16(1), С. 172 - 172
Опубликована: Янв. 4, 2024
Today,
type
2
diabetes
mellitus
(T2DM)
and
skeletal
muscle
atrophy
(SMA)
have
become
increasingly
common
occurrences.
Whether
the
onset
of
T2DM
increases
risk
SMA
or
vice
versa
has
long
been
under
investigation.
Both
conditions
are
associated
with
negative
changes
in
health,
which
can,
turn,
lead
to
impaired
physical
function,
a
lowered
quality
life,
an
increased
mortality.
Poor
nutrition
can
exacerbate
both
SMA.
linked
by
vicious
cycle
events
that
reinforce
worsen
each
other.
Muscle
insulin
resistance
appears
be
pathophysiological
link
between
To
explore
this
association,
our
review
(i)
compiles
evidence
on
clinical
association
SMA,
(ii)
reviews
mechanisms
underlying
biochemical
muscles
people
at
(iii)
examines
how
nutritional
therapy
activity
as
muscle-targeted
treatments
benefit
population.
Based
evidence,
we
conclude
effective
treatment
patients
T2DM-SMA
depends
restoration
maintenance
mass.
We
thus
propose
regular
intake
key
functional
nutrients,
along
guidance
for
activity,
help
maintain
euglycemia
improve
status
all
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2550 - 2550
Опубликована: Авг. 3, 2024
Polyphenols
are
natural
compounds
which
plant-based
bioactive
molecules,
and
have
been
the
subject
of
growing
interest
in
recent
years.
Characterized
by
multiple
varieties,
polyphenols
mostly
found
fruits
vegetables.
Currently,
many
diseases
waiting
for
a
cure
or
solution
to
reduce
their
symptoms.
However,
drug
other
chemical
strategies
limitations
using
treatment
agent
still
detection
tool
diseases,
thus
researchers
need
investigate
preventive
improving
treatment.
Therefore,
it
is
elucidate
polyphenols,
bioactivity
effects,
supplementation,
consumption.
The
disadvantage
that
they
limited
bioavailability,
although
beneficial
outcomes
with
roles.
In
this
context,
several
different
developed
improve
particularly
liposomal
nanoparticles.
As
nutrition
one
most
important
factors
health,
inclusion
molecules
daily
diet
significant
continues
be
enthusiastically
researched.
Nutrition,
individuals
all
ages,
key
polyphenols.
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 275 - 275
Опубликована: Янв. 13, 2025
Type
2
diabetes
mellitus
(T2DM),
a
serious
metabolic
disorder,
is
worldwide
health
problem
due
to
the
alarming
rise
in
prevalence
and
elevated
morbidity
mortality.
Chronic
hyperglycemia,
insulin
resistance,
ineffective
effect
secretion
are
hallmarks
of
T2DM,
leading
many
secondary
complications.
These
include,
particular,
cardiovascular
disorders,
diabetic
neuropathy,
nephropathy
retinopathy,
foot,
osteoporosis,
liver
damage,
susceptibility
infections
some
cancers.
Polyphenols
such
as
flavonoids,
phenolic
acids,
stilbenes,
tannins,
lignans
constitute
an
extensive
heterogeneous
group
phytochemicals
fresh
fruits,
vegetables
their
products.
Various
vitro
studies,
animal
model
studies
available
clinical
trials
revealed
that
flavonoids
(e.g.,
quercetin,
kaempferol,
rutin,
epicatechin,
genistein,
daidzein,
anthocyanins),
acids
chlorogenic,
caffeic,
ellagic,
gallic
curcumin),
stilbenes
resveratrol),
tannins
procyanidin
B2,
seaweed
phlorotannins),
pinoresinol)
have
ability
lower
enhance
sensitivity
improve
secretion,
scavenge
reactive
oxygen
species,
reduce
chronic
inflammation,
modulate
gut
microbiota,
alleviate
complications
T2DM.
The
interaction
between
polyphenols
conventional
antidiabetic
drugs
offers
promising
strategy
management
treatment
especially
advanced
disease
stages.
Synergistic
effects
with
been
documented,
but
also
antagonistic
interactions
may
impair
drug
efficacy.
Therefore,
additional
research
required
clarify
mutual
order
use
knowledge
applications.
Nevertheless,
dietary
can
be
successfully
applied
part
supportive
for
they
both
obvious
symptoms
Advances in Nutrition,
Год журнала:
2025,
Номер
unknown, С. 100376 - 100376
Опубликована: Янв. 1, 2025
Aging
is
associated
with
the
decline
of
tissue
and
cellular
functions,
which
can
promote
development
age-related
diseases
like
cancer,
cardiovascular
disease,
neurodegeneration,
disorders
musculoskeletal
immune
systems.
Healthspan
length
time
an
individual
in
good
health
free
from
chronic
disabilities
aging.
Two
modifiable
factors
that
influence
healthspan,
healthy
aging,
prevent
diseases,
are
diet
microbiota
gastrointestinal
tract
(gut
microbiota).
This
review
will
discuss
how
dietary
phytochemicals
gut
work
concert
to
a
First
overview
provided
influences
aging
through
its
impact
on
barrier
integrity,
function,
mitochondria
function
oxidative
stress.
Next,
mechanisms
by
effect
health,
inflammation,
nurture
diverse
microbial
composition
discussed.
Lastly,
directly
producing
bioactive
metabolites
food
urolithin
A,
equol,
hesperetin
sulforaphane.
These
other
phytochemical
derived
may
healthspan
Importantly,
individual's
capacity
produce
promoting
cruciferous
vegetables,
berries,
nuts,
citrus
soy
products
be
dependent
specific
bacteria
present
gut.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 577 - 577
Опубликована: Фев. 5, 2025
Background/Objectives:
With
the
increasing
life
expectancy
and,
as
a
result,
aging
of
global
population,
there
has
been
rise
in
prevalence
chronic
conditions,
which
can
significantly
impact
individuals’
health-related
quality
life,
multidimensional
concept
that
comprises
an
individual’s
physical,
mental,
and
social
wellbeing.
While
balanced,
nutrient-dense
diet,
such
Mediterranean
is
widely
recognized
for
its
role
disease
prevention,
particularly
reducing
risk
cardiovascular
diseases
certain
cancers,
potential
benefits
extend
beyond
these
well-known
effects,
showing
promise
improving
physical
mental
wellbeing,
promoting
life.
Methods:
A
systematic
search
scientific
literature
electronic
databases
(Pubmed/Medline)
was
performed
to
identify
potentially
eligible
studies
reporting
on
relation
between
adherence
diet
published
up
December
2024.
Results:
total
28
were
included
this
review,
comprising
13
conducted
among
general
population
15
involving
various
types
patients.
Overall,
most
showed
significant
association
HRQoL,
with
results
retrieved
domains
suggesting
seems
play
relevant
both
people
affected
by
conditions
inflammatory
basis.
Conclusions:
Adherence
provides
preventing
managing
commonly
associated
populations.
Furthermore,
it
enhances
overall
health
individuals,
ultimately
supporting
more
effective
less
invasive
treatment
approaches
diseases.
Biomolecules,
Год журнала:
2023,
Номер
13(9), С. 1402 - 1402
Опубликована: Сен. 17, 2023
Diabetes
mellitus
is
a
chronic
metabolic
disorder
characterized
by
hyperglycaemia
and
oxidative
stress.
Oxidative
stress
plays
crucial
role
in
the
development
progression
of
diabetes
its
complications.
Nutritional
antioxidants
derived
from
dietary
sources
have
gained
significant
attention
due
to
their
potential
improve
antidiabetic
therapy.
This
review
will
delve
into
world
polyphenols,
investigating
origins
plants,
metabolism
human
body,
relevance
antioxidant
mechanism
context
improving
therapy
attenuating
stress,
insulin
sensitivity,
preserving
β-cell
function.
The
mechanisms
of,
clinical
evidence
for,
future
perspectives
on
nutritional
as
adjuvant
management
are
discussed.
Applied Food Research,
Год журнала:
2024,
Номер
4(2), С. 100468 - 100468
Опубликована: Авг. 9, 2024
Given
the
environmental,
ethical,
and
food
security
challenges
posed
by
conventional
agriculture
animal
husbandry,
transition
towards
sustainable
systems
is
essential.
Plant-based
foods,
especially
those
enhanced
fermentation,
present
a
viable
solution.
Fermentation
reduces
ecological
footprint,
aligns
with
ethical
standards,
enhances
plant-based
proteins'
nutritional
value
sensory
attributes,
offering
credible
alternative
to
products.
This
paper
explores
fermentation's
transformative
role
in
developing
meats,
dairy,
protein
alternatives,
emphasizing
its
benefits,
including
improved
gut
health
through
probiotics
prebiotics.
It
also
addresses
such
as
producing
undesirable
by-products,
potential
risks,
increased
costs
associated
fermentation.
Detailed
examinations
of
specific
fermentation
processes—alcoholic,
lactic
acid,
acetic
propionic
butyric
acid—and
their
impact
on
enhancing
value,
digestibility,
flavor
foods
are
presented.
Case
studies
from
pioneering
companies
demonstrate
technologies'
practical
applications
market
potential.
Lastly,
discusses
future
opportunities
scaling
up
processes
incorporating
advanced
biotechnological
techniques
further
enhance
sustainability
outcomes.
