Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 11, 2024

Human melanoma is linked with aging-related disorders, prompting interest in the development of functional foods derived from natural ingredients to mitigate its incidence. Molecules green seaweeds such as Caulerpa racemosa can serve this purpose due their anti-tumor and anti-inflammatory properties. A previous work study compounds profiling has been carried out, research molecular docking studies targeting receptors associated (GRP78, IRE1, BRAF) aging (mTOR, AMPK, SIRT1) identified four promising compound an extract C. racemosa. The current aims mechanism those at a cellular level using human A375 (BRAF-V600E mutation) B16-F10 cell lines. MTT assay was used evaluate potential GSCRE against lines, comparisons made normal HDFa Results indicated that C2, also known Caulersin, demonstrated significantly different ∆G affinity binding score compared control drug Dabrafenib. crude extract, particularly showed modulating mTOR, SIRT1 pathways downregulating GRP78, BRAF signaling (p < 0.05). Interestingly, C2 less effective suppressing lines (LD

Язык: Английский