Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa DOI Creative Commons

Danar Wicaksono,

Nurpudji Astuti Taslim, Vincent Lau

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Human melanoma is linked with aging-related disorders, prompting interest in the development of functional foods derived from natural ingredients to mitigate its incidence. Molecules green seaweeds such as Caulerpa racemosa can serve this purpose due their anti-tumor and anti-inflammatory properties. A previous work study compounds profiling has been carried out, research molecular docking studies targeting receptors associated (GRP78, IRE1, BRAF) aging (mTOR, AMPK, SIRT1) identified four promising compound an extract C. racemosa. The current aims mechanism those at a cellular level using human A375 (BRAF-V600E mutation) B16-F10 cell lines. MTT assay was used evaluate potential GSCRE against lines, comparisons made normal HDFa Results indicated that C2, also known Caulersin, demonstrated significantly different ∆G affinity binding score compared control drug Dabrafenib. crude extract, particularly showed modulating mTOR, SIRT1 pathways downregulating GRP78, BRAF signaling (p < 0.05). Interestingly, C2 less effective suppressing lines (LD

Language: Английский

Characterization and Biological Activities of the Ulvan Polysaccharide-Rich Fraction Obtained from Ulva rigida and Ulva pseudorotundata and Their Potential for Pharmaceutical Application DOI

Thaís Fávero Massocato,

Víctor Robles-Carnero, Bruna Rodrigues Moreira

et al.

Marine Biotechnology, Journal Year: 2024, Volume and Issue: 26(2), P. 324 - 337

Published: March 2, 2024

Language: Английский

Citations

1
Exploring the therapeutic potential of polysaccharide from Portulaca oleracea L.: A review of phytochemistry and immunomodulatory effect DOI
Haixin Liu,

Lingling Ding,

Yanyan Chen

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 545, P. 109298 - 109298

Published: Oct. 23, 2024

Language: Английский

Citations

1
A comparative analysis on impact of drying methods on antioxidants, antidiabetes and antiobesity activities in green algae Caulerpa lentillifera: In vitro study DOI
Roike Iwan Montolalu, Verly Dotulong, Feny Mentang

et al.

Algal Research, Journal Year: 2024, Volume and Issue: 84, P. 103768 - 103768

Published: Oct. 22, 2024

Language: Английский

Citations

0
Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa DOI Creative Commons

Danar Wicaksono,

Nurpudji Astuti Taslim, Vincent Lau

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Human melanoma is linked with aging-related disorders, prompting interest in the development of functional foods derived from natural ingredients to mitigate its incidence. Molecules green seaweeds such as Caulerpa racemosa can serve this purpose due their anti-tumor and anti-inflammatory properties. A previous work study compounds profiling has been carried out, research molecular docking studies targeting receptors associated (GRP78, IRE1, BRAF) aging (mTOR, AMPK, SIRT1) identified four promising compound an extract C. racemosa. The current aims mechanism those at a cellular level using human A375 (BRAF-V600E mutation) B16-F10 cell lines. MTT assay was used evaluate potential GSCRE against lines, comparisons made normal HDFa Results indicated that C2, also known Caulersin, demonstrated significantly different ∆G affinity binding score compared control drug Dabrafenib. crude extract, particularly showed modulating mTOR, SIRT1 pathways downregulating GRP78, BRAF signaling (p < 0.05). Interestingly, C2 less effective suppressing lines (LD

Language: Английский

Citations

0