Biological Activities of Novel Oleanolic Acid Derivatives from Bioconversion and Semi-Synthesis

Molecules, Год журнала: 2024, Номер 29(13), С. 3091 - 3091

Опубликована: Июнь 28, 2024

Oleanolic acid (OA) is a vegetable chemical that present naturally in number of edible and medicinal botanicals. It has been extensively studied by chemists scientific researchers due to its biological activity against wide range diseases. A significant have synthesized variety analogues OA modifying structure with the intention creating more potent agents improving pharmaceutical properties. In recent years, enzymatic techniques employed investigate modify OA. This review presents advancements medical chemistry for structural modification OA, special focus on biotransformation, semi-synthesis relationship between modified structures their biopharmaceutical

Язык: Английский

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Regioselective synthesis, structural and bioactivity of acetylated 1,5-benzodiazepin-2-one derivatives — X-ray crystallography, DFT and molecular docking approaches

Journal of Molecular Structure, Год журнала: 2023, Номер 1296, С. 136799 - 136799

Опубликована: Окт. 5, 2023

Язык: Английский

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`Microencapsulation of Pancratium maritimum Essential Oil: GC–MS Analysis, Antimicrobial, Antibiofilm and Anticoagulant Effects and Molecular Docking Evaluation

Chemistry Africa, Год журнала: 2024, Номер 7(9), С. 4815 - 4831

Опубликована: Авг. 13, 2024

Язык: Английский

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Eucalyptus torquata, Eucalyptus woodwardii and Their Hybrid Eucalyptus torwood Essential Oils: GC-MS Profile, In Vitro Evaluation of the Antimicrobial Activities, Molecular Docking Study and in Silico ADME Profiling

Chemistry Africa, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Язык: Английский

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Design, semi-synthesis and molecular docking of new antibacterial and antibiofilm triazole conjugates from hydroxy-triterpene acids and fluoroquinolones

New Journal of Chemistry, Год журнала: 2023, Номер 47(34), С. 15973 - 15986

Опубликована: Янв. 1, 2023

Maslinic acid- and oleanolic acid-based hyrids with potent antibacterial antibiofilm activities were designed semi-synthesized from pentacyclic triterpene acids isolated olive oil manufacturing solid waste.

Язык: Английский

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Biological Properties of Oleanolic Acid Derivatives Bearing Functionalized Side Chains at C-3

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8480 - 8480

Опубликована: Авг. 3, 2024

Triterpene acids are a class of pentacyclic natural carboxylic compounds endowed with variety biological activities including antitumor, antimicrobial, and hepatoprotective effects. In this work, several oleanolic acid derivatives were synthesized by structurally modifying them on the C-3 position. All evaluated for possible antibacterial antiviral activity, among all epimers, 6 7 demonstrated best activities. Zone-of-inhibition analyses conducted against two strains, E. coli as Gram-negative S. aureus Gram-positive model. Subsequently, experiments performed using microdilution method to determine minimum inhibitory concentration (MIC). The results showed that only derivative reduced hydrogen bonding ability ring A possesses remarkable activity toward coli. conversion from methyl ester implies loss probably due affinity bacterial membrane. Before cytotoxicity triterpenes was through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Samples less than 50% at 0.625 1 mg/mL, respectively. SARS-CoV-2 PV-1 did not indicate triterpene had any capacity in sub-toxic range.

Язык: Английский

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Allylboration of azole aldehydes: enantioselective synthesis of homoallylic azole alcohols and reconsideration of the mechanism of enantioselectivity

Russian Chemical Bulletin, Год журнала: 2024, Номер 73(10), С. 2910 - 2920

Опубликована: Окт. 1, 2024

Язык: Английский

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