Protective Effects of Oleanolic Acid on Human Keratinocytes: A Defense Against Exogenous Damage
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 238 - 238
Опубликована: Фев. 11, 2025
Background/objectives:
Aging
leads
to
increased
oxidative
stress
and
chronic
inflammation
in
the
skin,
which
contribute
various
disorders
such
as
dermatitis
cancer.
This
study
explores
cytoprotective
effects
of
oleanolic
acid
(OA),
a
natural
triterpenoid
compound
known
for
its
potential
mitigating
damage,
on
human
keratinocyte
(HaCaT)
cells
exposed
from
tert-butyl
hydroperoxide
(tBHP).
Methods:
Using
vitro
experiments,
we
assessed
cell
viability,
reactive
oxygen
species
(ROS)
levels,
nitric
oxide
(NO)
production,
protein
expression
following
OA
pre-treatment.
Advanced
imaging
techniques
were
employed
visualize
localization.
Results:
Results
demonstrated
that
significantly
improved
viability
reduced
intracellular
ROS
levels
compared
with
those
controls.
Additionally,
inhibited
inducible
synthase
(iNOS)
subsequent
release,
indicating
modulation
inflammatory
responses.
Notably,
while
tBHP
activated
Nrf2/HO-1
signaling
pathway,
did
not
enhance
this
response,
suggesting
exerts
through
mechanisms
independent
Nrf2
activation.
Conclusion:
shows
promise
protecting
HaCaT
tBHP-induced
stress,
highlighting
role
promoting
skin
health
addressing
aging-related
damage.
The
proposes
operates
pathways
distinct
MAPKs,
paving
way
new
therapeutic
strategies
aimed
at
improving
against
stress.
Язык: Английский
New Derivatives of Oleanolic Acid: Semi-Synthesis and Evaluation of Their Anti-15-LOX, Anti-α-Glucosidase and Anticancer Activities and Molecular Docking Studies
Chemistry,
Год журнала:
2025,
Номер
7(2), С. 36 - 36
Опубликована: Март 7, 2025
A
novel
series
of
oleanolic
acid
(OA,
1)
derivatives
incorporating
phenolic
and
coumarin
moieties
were
synthesized.
This
was
extracted
from
olive
pomace
(Olea
europaea
L.)
using
an
ultrasound-assisted
method.
The
structures
these
OA
characterized
through
the
utilization
1H-NMR,
13C-NMR
ESI-HRMS
analyses.
An
evaluation
some
biological
activities
prepared
conducted.
focused
principally
on
capacity
to
inhibit
15-lipoxygenase
α-glucosidase,
as
well
their
anticancer
properties
when
tested
against
tumour
cell
lines
(HCT-116
LS-174T)
a
non-tumour
line
(HEK-293).
In
terms
cytotoxic
activity,
majority
compounds
exhibited
notable
inhibitory
effects
compared
starting
molecule,
OA.
Derivatives
4d,
4k
4m
particularly
strong
HCT-116
line,
with
IC₅₀
values
38.5,
39.3,
40.0
µM,
respectively.
4l,
4e
5d
demonstrated
most
effective
inhibition
LS-174T
IC50
44.0,
44.3,
38.0
However,
compound
2a
effective,
exhibiting
potent
52.4
59.5
Furthermore,
molecular
docking
studies
supported
in
vitro
revealing
that
low
binding
energies
interacted
effectively
within
EGFR
enzyme’s
active
pocket
(PDB:
1M17).
These
findings
highlight
potential
agents
enzymatic
inhibitors,
warranting
further
investigation.
Язык: Английский
Synthesis of novel bioactive amides derived from carbazole moiety with deep-blue and single-component white photoluminescence
Journal of Photochemistry and Photobiology A Chemistry,
Год журнала:
2025,
Номер
unknown, С. 116394 - 116394
Опубликована: Март 1, 2025
Язык: Английский
Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 10421 - 10440
Опубликована: Дек. 1, 2024
Despite
advancements
in
cancer
treatment
through
surgery
and
drugs,
hepatocellular
carcinoma
(HCC)
remains
a
significant
challenge,
as
reflected
by
its
low
survival
rates.
The
mammalian
target
of
rapamycin
(mTOR)
signaling
pathway
plays
crucial
role
regulating
the
cell
cycle,
proliferation,
apoptosis,
metabolism.
Notably,
dysregulation
leading
to
activation
mTOR
is
common
HCC,
making
it
key
focus
for
in-depth
research
current
therapeutic
strategies.
This
review
focuses
on
downstream
effectors
HCC
autophagy,
metabolic
reprogramming.
Moreover,
emphasizes
potential
natural
products
modulators
pathway.
When
incorporated
into
combination
therapies,
these
have
been
demonstrated
augment
efficacy
surmount
drug
resistance.
These
pathways
such
pathways.
Examples
include
11-epi-sinulariolide
acetate,
matrine,
asparagus
polysaccharide.
Their
inhibitory
effects
processes
suggest
valuable
directions
development
more
effective
Various
ability
inhibit
suppress
progression.
phytochemicals,
functioning
inhibitors,
hold
great
promise
anti-HCC
agents,
especially
context
overcoming
chemoresistance
enhancing
outcomes
therapies.
Язык: Английский