Novel inhibitors of PARP1 and PARP14: design, synthesis, and potentiation of cisplatin efficacy in cancer DOI
Caleb M. T. Kam, Amanda L Tauber, Matthew Zunk

и другие.

Future Medicinal Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Дек. 18, 2024

Poly(ADP-ribose) polymerase (PARP) is a superfamily of enzymes involved in cell survival. Both PARP1 and PARP14 are overexpressed malignancies. No clinically approved inhibitors available, generally nonspecific, resulting need for more diverse library selective inhibitors.

Язык: Английский

Computational Design and Structural Insights into Quinazoline-Based Lead Molecules for Targeting PARP10 in Cancer Therapy DOI

Revathi Gnanavelou,

Manikandan Jayaraman,

Jeyaraman Jeyakanthan

и другие.

Journal of Molecular Graphics and Modelling, Год журнала: 2025, Номер 137, С. 109005 - 109005

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
Discovery of tricyclic PARP7 inhibitors with high potency, selectivity, and oral bioavailability DOI
Juan Xu,

Anmin Zhao,

Danni Chen

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 266, С. 116160 - 116160

Опубликована: Янв. 18, 2024

Язык: Английский

Процитировано

3
Exploring the structural-activity relationship of hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]oxazine derivatives as potent and orally-bioavailable PARP7 inhibitors DOI
Silong Zhang, Yu Zhang, Ziwei Wang

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 261, С. 115836 - 115836

Опубликована: Окт. 9, 2023

Язык: Английский

Процитировано

2
Novel inhibitors of PARP1 and PARP14: design, synthesis, and potentiation of cisplatin efficacy in cancer DOI
Caleb M. T. Kam, Amanda L Tauber, Matthew Zunk

и другие.

Future Medicinal Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Дек. 18, 2024

Poly(ADP-ribose) polymerase (PARP) is a superfamily of enzymes involved in cell survival. Both PARP1 and PARP14 are overexpressed malignancies. No clinically approved inhibitors available, generally nonspecific, resulting need for more diverse library selective inhibitors.

Язык: Английский

Процитировано

0